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The Sarcomere and Sarcomerogenesis

  • Elisabeth Ehler
  • Mathias Gautel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 642)

Abstract

Striated muscle owes its name to the microscopic appearance, caused by the longitudinal alignment of thousands of highly ordered contractile units, the sarcomeres. The assembly (and disassembly) of these multiprotein complexes (sarcomere assembly or sarcomerogenesis) follows ordered pathways, which are regulated on the transcriptional, translational and posttranslational level. Furthermore, myofibril assembly involves the participation of transient scaffolds and adaptors, notably the microtubule network. Studies in cell culture and developing embryos have revealed common pathways of sarcomere assembly in heart and skeletal muscle. Disruptions in these pathways are implicated in muscle diseases.

Keywords

Skeletal Muscle Skeletal Muscle Cell Sarcomeric Protein Nonmuscle Myosin Human Skeletal Muscle Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  1. 1.Cardiovascular Division and Randall Division for Cell and Molecular BiophysicsKing’s College LondonLondonUK

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