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Smoking and the kidney

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Clinical Nephrotoxins
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Smoking, mostly cigarette smoking, is one of the most important modifiable renal risk factor. In contrast to the long known potential of cigarette smoking to promote carcinogenesis, lung disease and cardiovascular events, even in the renal community the renal risk has only recently attracted attention [1], although the renal risk conferred by smoking had been known to diabetologists for more than 2 decades [2].

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References

  1. Orth SR, Ritz E, Schrier RW: The renal risks of smoking. Kidney Int 51:1669-1677, 1997.

    Article  PubMed  Google Scholar 

  2. Christiansen JS: Cigarette smoking and prevalence of microangiopathy in juvenile-onset insulin-dependent diabetes mellitus. Diabetes Care 1:146-149, 1978.

    Article  PubMed  Google Scholar 

  3. Hesse E: Einfluss des Rauchens auf den Kreislauf. Deutsches Archiv klinische Medizin 89:565-575, 1907.

    Google Scholar 

  4. Green MS, Jucha E, Luz Y: Blood pressure in smokers and nonsmokers: epidemiologic findings. Am Heart J 111:932-940, 1986.

    Article  PubMed  Google Scholar 

  5. Cryer PE, Haymond MW, Santiago JV, Shah SD: Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events. N Engl J Med 295:573-577, 1976

    PubMed  Google Scholar 

  6. Ritz S: Einfluss des Rauchens auf Blutdruck und Herzfrequenz bei Probanden mit und ohne primäre Nierenerkrankung. Inaugu-raldissertation (Medizinische Fakultät der Ruprecht-Karls-Universität Heidelberg), 2003.

    Google Scholar 

  7. Yasmin, Falzone R, Brown MJ: Determinants of arterial stiffness in offspring of families with essential hypertension. Am J Hypertens 17:292-298, 2004.

    Article  PubMed  Google Scholar 

  8. Narkiewicz K, Kjeldsen SE, Hedner T: Is smoking a causative factor of hypertension? Blood Press 14:69-71, 2005.

    Article  PubMed  Google Scholar 

  9. Ritz E, Benck U, Franek E, Keller C, Seyfarth M, Clorius J: Effects of smoking on renal hemodynamics in healthy volunteers and in patients with glomerular disease. J Am Soc Nephrol 9:1798-1804, 1998.

    PubMed  Google Scholar 

  10. Benck U, Clorius JH, Zuna I, Ritz E: Renal hemodynamic changes during smoking: effects of adrenoreceptor blockade. Eur J Clin Invest 29:1010-1018, 1999.

    Article  PubMed  Google Scholar 

  11. Odoni G, Ogata H, Viedt C, Amann K, Ritz E, Orth SR: Cigarette smoke condensate aggravates renal injury in the renal ablation model. Kidney Int 61:2090-2098, 2002.

    Article  PubMed  Google Scholar 

  12. Halimi JM, Giraudeau B, Vol S, Caces E, Nivet H, Lebranchu Y, Tichet J: Effects of current smoking and smoking discontinuation on renal function and proteinuria in the general population. Kidney Int 58:1285-1292, 2000.

    Article  PubMed  Google Scholar 

  13. Gambaro G, Verlato F, Budakovic A, Casara D, Saladini G, Del Prete D, Bertaglia G, Masiero M, Checchetto S, Baggio B: Renal impairment in chronic cigarette smokers. J Am Soc Nephrol 9:562-567, 1998.

    PubMed  Google Scholar 

  14. Lhotta K, Rumpelt HJ, Konig P, Mayer G, Kronenberg F: Cigarette smoking and vascular pathology in renal biopsies. Kidney Int 61:648-654, 2002.

    Article  PubMed  Google Scholar 

  15. Orth SR, Schroeder T, Ritz E, Ferrari P: Effects of smoking on renal function in patients with type 1 and type 2 diabetes mellitus. Nephrol Dial Transplant 20:2414-2419, 2005.

    Article  PubMed  Google Scholar 

  16. Mimran A, Ribstein J, DuCailar G, Halimi JM: Albuminuria in normals and essential hypertension. J Diabetes Complications 8:150-156, 1994.

    Article  PubMed  Google Scholar 

  17. Hörner D, Fliser D, Klimm HP, Ritz E: Albuminuria in normotensive and hypertensive individuals attending offices of general practitioners. J Hypertens 14:655-660, 1996.

    Article  PubMed  Google Scholar 

  18. Pinto-Sietsma SJ, Mulder J, Janssen WM, Hillege HL, de Zeeuw D, de Jong PE: Smoking is related to albuminuria and abnormal renal function in nondiabetic persons. Ann Intern Med 133:585-591, 2000.

    PubMed  Google Scholar 

  19. Hogan S.H.,Colindres R.E., Cai J., Coresh J.: Association of Smoking with Albuminuria in a cross-sectional Probability Sample of US Adults. J.Am.Soc.Nephrol. 12:209a, 2001.

    Google Scholar 

  20. Tozawa M, Iseki K, Iseki C, Oshiro S, Ikemiya Y, Takishita S: Influence of smoking and obesity on the development of proteinuria. Kidney Int 62:956-962, 2002.

    Article  PubMed  Google Scholar 

  21. Hadj-Abdelkader M, Alphonse JC, Boyer L, Younes H, Deteix P: [Smoking and atheromatous stenosis of the renal arteries]. Arch Mal Coeur Vaiss 94:925-927, 2001.

    PubMed  Google Scholar 

  22. Shurrab AE, Mamtora H, O’Donoghue D, Waldek S, Kalra PA: Increasing the diagnostic yield of renal angiography for the diagnosis of atheromatous renovascular disease. Br J Radiol 74:213-218, 2001.

    PubMed  Google Scholar 

  23. Scolari F, Tardanico R, Zani R, Pola A, Viola BF, Movilli E, Maiorca R: Cholesterol crystal embolism: A recognizable cause of renal disease. Am J Kidney Dis 36:1089-1109, 2000.

    PubMed  Google Scholar 

  24. Baggio B, Budakovic A, Casara D, Gambaro G, Saladini G, Piccoli A, Verlato F: Renal involvement in subjects with peripheral atherosclerosis. J Nephrol 14:286-292, 2001.

    PubMed  Google Scholar 

  25. Markowitz GS, Lin J, Valeri AM, Avila C, Nasr SH, D’Agati VD: Idiopathic nodular glomerulosclerosis is a distinct clinicopathologic entity linked to hypertension and smoking. Hum Pathol 33:826-835, 2002.

    Article  PubMed  Google Scholar 

  26. Liang KV, Greene EL, Oei LS, Lewin M, Lager D, Sethi S: Nodular glomerulosclerosis: renal lesions in chronic smokers mimic chronic thrombotic microangiopathy and hypertensive lesions. Am J Kidney Dis 49:552-559, 2007.

    Article  PubMed  Google Scholar 

  27. Telmer S, Christiansen JS, Andersen AR, Nerup J, Deckert T: Smoking habits and prevalence of clinical diabetic microangiopathy in insulin-dependent diabetics. Acta Med Scand 215:63-68, 1984.

    PubMed  Google Scholar 

  28. Rossing P, Hougaard P, Parving HH: Risk factors for development of incipient and overt diabetic nephropathy in type 1 diabetic patients: a 10-year prospective observational study. Diabetes Care 25:859-864, 2002.

    Article  PubMed  Google Scholar 

  29. Scott LJ, Warram JH, Hanna LS, Laffel LM, Ryan L, Krolewski AS: A nonlinear effect of hyperglycemia and current cigarette smoking are major determinants of the onset of microalbuminuria in type 1 diabetes. Diabetes 50:2842-2849, 2001.

    Article  PubMed  Google Scholar 

  30. Chase HP, Garg SK, Marshall G, Berg CL, Harris S, Jackson WE, Hamman RE: Cigarette smoking increases the risk of albuminuria among subjects with type I diabetes. Jama 265:614-617, 1991.

    Article  PubMed  Google Scholar 

  31. Bangstad HJ, Osterby R, Rudberg S, Hartmann A, Brabrand K, Hanssen KF: Kidney function and glomerulopathy over 8 years in young patients with Type I (insulin-dependent) diabetes mellitus and microalbuminuria. Diabetologia 45:253-261, 2002.

    Article  PubMed  Google Scholar 

  32. Sawicki PT, Didjurgeit U, Muhlhauser I, Bender R, Heinemann L, Berger M: Smoking is associated with progression of diabetic nephropathy. Diabetes Care 17:126-131, 1994.

    Article  PubMed  Google Scholar 

  33. Biesenbach G, Grafinger P, Janko O, Zazgornik J: Influence of cigarette-smoking on the progression of clinical diabetic nephropathy in type 2 diabetic patients. Clin Nephrol 48:146-150, 1997.

    PubMed  Google Scholar 

  34. Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, Willett WC: Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 345:790-797, 2001.

    Article  PubMed  Google Scholar 

  35. Patja K, Jousilahti P, Hu G, Valle T, Qiao Q, Tuomilehto J: Effects of smoking, obesity and physical activity on the risk of type 2 diabetes in middle-aged Finnish men and women. J Intern Med 258:356-362, 2005.

    Article  PubMed  Google Scholar 

  36. Ward MM, Studenski S: Clinical prognostic factors in lupus nephritis. The importance of hypertension and smoking. Arch Intern Med 152:2082-2088, 1992.

    Article  PubMed  Google Scholar 

  37. Chapman AB, Johnson AM, Gabow PA, Schrier RW: Overt proteinuria and microalbuminuria in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 5:1349-1354, 1994.

    PubMed  Google Scholar 

  38. Orth SR, Stockmann A, Conradt C, Ritz E, Ferro M, Kreusser W, Piccoli G, Rambausek M, Roccatello D, Schafer K, Sieberth HG, Wanner C, Watschinger B, Zucchelli P: Smoking as a risk factor for end-stage renal failure in men with primary renal disease. Kidney Int 54:926-931, 1998.

    Article  PubMed  Google Scholar 

  39. Chuahirun T, Wesson DE: Cigarette smoking predicts faster progression of type 2 established diabetic nephropathy despite ACE inhibition. Am J Kidney Dis 39:376-382, 2002.

    Article  PubMed  Google Scholar 

  40. Regalado M, Yang S, Wesson DE: Cigarette smoking is associated with augmented progression of renal insufficiency in severe essential hypertension. Am J Kidney Dis 35:687-694, 2000.

    Article  PubMed  Google Scholar 

  41. Bleyer AJ, Shemanski LR, Burke GL, Hansen KJ, Appel RG: Tobacco, hypertension, and vascular disease: risk factors for renal functional decline in an older population. Kidney Int 57:2072-2079, 2000.

    Article  PubMed  Google Scholar 

  42. Haroun MK, Jaar BG, Hoffman SC, Comstock GW, Klag MJ, Coresh J: Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in washington county, Maryland. J Am Soc Nephrol 14:2934-2941, 2003.

    Article  Google Scholar 

  43. Ejerblad E, Fored CM, Lindblad P, Fryzek J, Dickman PW, Elinder CG, McLaughlin JK, Nyren O: Association between smoking and chronic renal failure in a nationwide population-based case-control study. J Am Soc Nephrol 15:2178-2185, 2004.

    Article  PubMed  Google Scholar 

  44. Ishani A, Grandits GA, Grimm RH, Svendsen KH, Collins AJ, Prineas RJ, Neaton JD: Association of single measurements of dipstick proteinuria, estimated glomerular filtration rate, and hematocrit with 25-year incidence of end-stage renal disease in the multiple risk factor intervention trial. J Am Soc Nephrol 17:1444-1452, 2006.

    Article  PubMed  Google Scholar 

  45. Stengel B, Tarver-Carr ME, Powe NR, Eberhardt MS, Brancati FL: Lifestyle factors, obesity and the risk of chronic kidney disease. Epidemiology 14:479-487, 2003.

    PubMed  Google Scholar 

  46. Woo YM, McLean D, Kavanagh D, Ward L, Aitken S, Miller GJ, Egan P, Hughes K, Clark L, Carswell K, Morris ST, Northridge DB, Rodger RS, Jardine AG: The influence of pre-operative electrocardiographic abnormalities and cardiovascular risk factors on patient and graft survival following renal transplantation. J Nephrol 15:380-386, 2002.

    PubMed  Google Scholar 

  47. Sung RS, Althoen M, Howell TA, Ojo AO, Merion RM: Excess risk of renal allograft loss associated with cigarette smoking. Trans- plantation 71:1752-1757, 2001.

    Google Scholar 

  48. Remuzzi G, Schieppati A, Ruggenenti P: Clinical practice. Nephropathy in patients with type 2 diabetes. N Engl J Med 346:1145-1151, 2002.

    Article  PubMed  Google Scholar 

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Ritz, E. (2008). Smoking and the kidney. In: De Broe, M.E., Porter, G.A., Bennett, W.M., Deray, G. (eds) Clinical Nephrotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-84843-3_42

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  • DOI: https://doi.org/10.1007/978-0-387-84843-3_42

  • Publisher Name: Springer, Boston, MA

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