Skip to main content
SpringerLink
Log in
Book cover

Clinical Nephrotoxins pp 757–769Cite as

Herbal remedies containing aristolochic acid and mushroom nephrotoxicity

  • Chapter

Numerous myths have grown around medicinal herbs and their healing powers [1]. The myth of beneficent nature is resistant to the accumulated evidence of health problems resulting from unknown or underestimated toxicity as well as from adulteration and misidentification of medicinal herbs [2]. Many plants contain substances toxic to humans and therefore, not surprisingly, to the human kidney. In early 1993, a rapidly progressive kidney fail ure leading to end-stage renal disease was reported in a number of women who had ingested slimming pills that contained powdered Chinese herbs [3]. Further investigations showed that this so called “Chinese herb nephropathy” was, in fact, secondary to the replacement of one of the prescribed Chinese herb, Stephania tetrandra, by other mixtures of Chinese herbs containing Aristolochia Fang chi [4]. The term “Aristolochia nephropathy” was thus proposed to be used instead of “Chinese herb nephropathy (CHN)” [5]. Finally, due to the presence of aristolochic acids (AA) in Aristolochia spp. and to their further demonstrated nephrotoxicity (see below), the term of “Aristolochic acid nephropathy” (AAN) is now commonly used.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Vanherweghem JL. Nephropathy and herbal medicine. Am J Kidney Dis 2000; 35: 330-332

    PubMed  CAS  Google Scholar 

  2. Huxtable RJ. The myth of beneficent nature: the risks of herbal preparations. Ann Intern Med 1992; 117: 165-166

    PubMed  CAS  Google Scholar 

  3. Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vandervelde D, Verbeelen D, Vanhaelen-Fastre R. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 1993; 341: 387-391

    PubMed  CAS  Google Scholar 

  4. Vanhaelen M, Vanhaelen-Fastre R, But P, Vanherweghem JL. Identification of aristolochic acid in Chinese herbs. Lancet 1994; 343: 174 (letter)

    PubMed  CAS  Google Scholar 

  5. Vanherweghem JL. Aristolochia nephropathy in humans: an outbreak in Belgium. J Am Soc Nephrol 1993; 4: 327 (abstract)

    Google Scholar 

  6. Vanherweghem JL. Misuse of herbal remedies: the case of an outbreak of terminal renal failure in Belgium (Chinese herbs ne-phropathy). J Altern Complement Med 1998; 4: 9-13

    PubMed  CAS  Google Scholar 

  7. But PP. Need for correct identification of herbs in herbal poisoning. Lancet 1993; 341: 637 (letter)

    PubMed  CAS  Google Scholar 

  8. Pourrat J, Montastruc JL, Lacombe JL, Cisterne JM, Rascol O, Dumazer P. Néphropathie associée à des herbes chinoises - 2 cas. Presse Med 1994; 23: 1669 (letter)

    PubMed  CAS  Google Scholar 

  9. Stengel B, Jones E. Insuffisance rénale terminale associée à la consommation d’herbes chinoises en France. Néphrologie 1998; 19: 15-20

    PubMed  CAS  Google Scholar 

  10. Pena JM, Borras M, Ramos J, Montoliu J. Rapidly progressive interstitial renal fibrosis due to a chronic intake of a herb (Aristolochia pistolochia) infusion. Nephrol Dial Transplant 1996; 11: 1359-1360

    PubMed  CAS  Google Scholar 

  11. Lord GM, Tagore R, Cook T, Gower P, Pusey CD. Nephropathy caused by Chinese herbs in the UK. Lancet 1999; 354: 481-482

    PubMed  CAS  Google Scholar 

  12. Cronin AJ, Maidment G, Cook T, Kite GC, Simmonds MS, Pusey CD, Lord GM. Aristolochic acid as a causative factor in a case of Chinese herbal nephropathy. Nephrol Dial Transplant 2002; 17: 524-525

    PubMed  Google Scholar 

  13. Laing C, Hamour S, Sheaff M, Miller R, Woolfson R. Chinese herbal uropathy and nephropathy. Lancet 2006; 368: 338

    PubMed  Google Scholar 

  14. Meyer MM, Chen TP, Bennett WM. Chinese herb nephropathy. Proc (Bayl Univ Med Cent) 2000; 13: 334-337

    CAS  Google Scholar 

  15. Yang CS, Lin CH, Chang SH, Hsu HC. Rapidly progressive fibrosing interstitial nephritis associated with Chinese herbal drugs. Am J Kidney Dis 2000; 35: 313-318

    PubMed  CAS  Google Scholar 

  16. Chang CH, Wang YM, Yang AH, Chiang SS. Rapidly progressive interstitial renal fibrosis associated with Chinese herbal medica-tions. Am J Nephrol 2001; 21: 441-448

    PubMed  CAS  Google Scholar 

  17. Tanaka A, Nishida R, Yokoi H, Kuwahara T. The characteristic pattern of aminoaciduria in patients with aristolochic acid-induced Fanconi syndrome: could iminoaciduria be the hallmark of this syndrome? Clin Nephrol 2000; 54: 198-202

    PubMed  CAS  Google Scholar 

  18. Tanaka A, Nishida R, Maeda K, Sugawara A, Kuwahara T. Chinese herb nephropathy in Japan presents adult-onset Fanconi syndrome: could different components of aristolochic acids cause a different type of Chinese herb nephropathy? Clin Nephrol 2000; 53: 301-306

    PubMed  CAS  Google Scholar 

  19. Krumme B, Endmeir R, Vanhaelen M, Walb D. Reversible Fanconi syndrome after ingestion of a Chinese herbal ‘remedy’ contain-ing aristolochic acid. Nephrol Dial Transplant 2001; 16: 400-402

    PubMed  CAS  Google Scholar 

  20. Yang SS, Chu P, Lin YF, Chen A, Lin SH. Aristolochic acid-induced Fanconi’s syndrome and nephropathy presenting as hypokalemic paralysis. Am J Kidney Dis 2002; 39: E14

    PubMed  Google Scholar 

  21. Tsai CS, Chen YC, Chen HH, Cheng CJ, Lin SH. An unusual cause of hypokalemic paralysis: aristolochic acid nephropathy with Fanconi syndrome. Am J Med Sci 2005; 330: 153-155

    PubMed  Google Scholar 

  22. Lo SH, Mo KL, Wong KS, Poon SP, Chan CK, Lai CK, Chan A. Aristolochic acid nephropathy complicating a patient with focal segmental glomerulosclerosis. Nephrol Dial Transplant 2004; 19: 1913-1915

    PubMed  Google Scholar 

  23. Yang L, Li X, Wang H. Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis. Nephrol Dial Transplant 2007; 22: 445-456

    PubMed  CAS  Google Scholar 

  24. van Ypersele de Strihou C, Vanherweghem JL. The tragic paradigm of Chinese herbs nephropathy. Nephrol Dial Transplant 1995; 10: 157-160

    PubMed  CAS  Google Scholar 

  25. Kabanda A, Jadoul M, Lauwerys R, Bernard A, van Ypersele de Strihou C. Low molecular weight proteinuria in Chinese herbs nephropathy. Kidney Int 1995; 48: 1571-1576

    PubMed  CAS  Google Scholar 

  26. Nortier JL, Deschodt-Lanckman MM, Simon S, Thielemans NO, de Prez EG, Depierreux MF, Tielemans CL, Richard C, Lauwerys RR, Bernard AM, Vanherweghem JL. Proximal tubular injury in Chinese herbs nephropathy: monitoring by neutral endopeptidase enzymuria. Kidney Int 1997; 51: 288-293

    PubMed  CAS  Google Scholar 

  27. Vanherweghem JL, Abramowicz D, Tielemans C, Depierreux M. Effects of steroids on the progression of renal failure in chronic interstitial renal fibrosis: a pilot study in Chinese herbs nephropathy. Am J Kidney Dis 1996; 27: 209-215

    PubMed  CAS  Google Scholar 

  28. Muniz Martinez MC, Nortier J, Vereerstraeten P, Vanherweghem JL. Steroid therapy in chronic interstitial renal fibrosis: the case of Chinese-herb nephropathy. Nephrol Dial Transplant 2002; 17: 2033-2034

    CAS  Google Scholar 

  29. Vanherweghem JL. Association of valvular heart disease with Chinese-herb nephropathy. Lancet 1997; 350: 1858 (letter)

    PubMed  CAS  Google Scholar 

  30. Reginster F, Jadoul M, van Ypersele de Strihou C. Chinese herbs nephropathy presentation, natural history and fate after trans-plantation. Nephrol Dial Transplant 1997; 12: 81-86

    PubMed  CAS  Google Scholar 

  31. Connolly HM, Crary JL, McGoon MD, Hensrud DD, Edwards BS, Edwards WD, Schaff HV. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med 1997; 337: 581-588

    PubMed  CAS  Google Scholar 

  32. Unger P, Nortier J, Muniz Martinez MC, Plein D, Vandenbossche JL, Vereerstraeten P, Vanherweghem JL. High prevalence of fen-fluramine-related aortic regurgitation in women with end-stage renal disease secondary to Chinese herb nephropathy. Nephrol Dial Transplant 2003; 18: 906-910

    PubMed  CAS  Google Scholar 

  33. Cosyns JP, Jadoul M, Squifflet JP, de Plaen JF, Ferluga D, van Ypersele de Strihou C. Chinese herbs nephropathy: a clue to Balkan endemic nephropathy? Kidney Int 1994; 45: 1680-1688

    PubMed  CAS  Google Scholar 

  34. Depierreux M, Van Damme B, Vanden Houte K, Vanherweghem JL. Pathologic aspects of a newly described nephropathy related to the prolonged use of Chinese herbs. Am J Kidney Dis 1994; 24: 172-180

    PubMed  CAS  Google Scholar 

  35. Jadoul M, de Plaen JF, Cosyns JP, van Ypersele de Strihou C. Adverse effects from traditional Chinese medicine. Lancet 1993; 341: 892-893

    PubMed  CAS  Google Scholar 

  36. Cosyns JP, Jadoul M, Squifflet JP, Van Cangh PJ, van Ypersele de Strihou C. Urothelial malignancy in nephropathy due to Chinese herbs. Lancet 1994; 344: 188 (letter)

    PubMed  CAS  Google Scholar 

  37. Vanherweghem JL, Tielemans C, Simon J, Depierreux M. Chinese herbs nephropathy and renal pelvic carcinoma. Nephrol Dial Transplant 1995; 10: 270-273

    PubMed  CAS  Google Scholar 

  38. Lord GM, Cook T, Arlt VM, Schmeiser HH, Williams G, Pusey CD. Urothelial malignant disease and Chinese herbal nephropathy. Lancet 2001; 358: 1515-1516

    PubMed  CAS  Google Scholar 

  39. Cosyns JP, Jadoul M, Squifflet JP, Wese FX, van Ypersele de Strihou C. Urothelial lesions in Chinese-herb nephropathy. Am J Kidney Dis 1999; 33: 1011-1017

    PubMed  CAS  Google Scholar 

  40. Nortier JL, Muniz Martinez MC, Schmeiser HH, Arlt VM, Bieler CA, Petein M, Depierreux MF, De Pauw L, Abramowicz D, Vereer-straeten P, Vanherweghem JL. Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N Engl J Med 2000; 342: 1686-1692

    PubMed  CAS  Google Scholar 

  41. Lemy A, Wissing KM, Rorive S, Zlotta A, Roumeguere T, Muniz Martinez MC, Decaestecker C, Salmon I, Abramowicz D, Vanher-weghem JL, Nortier J. Late onset of bladder urothelial carcinoma after kidney transplantation for end-stage aristolochic acid nephropathy: a case series with 15-year follow-up. Am J Kidney Dis 2008; 51: 471-477

    PubMed  Google Scholar 

  42. Nortier JL, Schmeiser HH, Muniz Martinez MC, Arlt VM, Vervaet C, Garbar CH, Daelemans P, Vanherweghem JL. Invasive urothe-lial carcinoma after exposure to Chinese herbal medicine containing aristolochic acid may occur without severe renal failure. Nephrol Dial Transplant 2003; 18: 426-428

    PubMed  CAS  Google Scholar 

  43. Stefanovic V, Polenakovic MH. Balkan nephropathy. Kidney disease beyond the Balkans? Am J Nephrol 1991; 11: 1-11

    PubMed  CAS  Google Scholar 

  44. Mengs U. Acute toxicity of aristolochic acid in rodents. Arch Toxicol 1987; 59: 328-331

    PubMed  CAS  Google Scholar 

  45. Jackson L, Kofman S, Weiss A, Brodovsky H. Aristolochic Acid (NSC-50413): Phase I Clinical Study. Cancer Chemotherapy Reports 1964; 35-37

    Google Scholar 

  46. Mengs U, Lang W, Poch J-A. The carcinogenic action of aristolochic acid in rats. Arch Toxicol 1982; 57: 107-119

    Google Scholar 

  47. Malak J. Chinese herb nephropathy is not a (dex)fenfluramine nephropathy but a serotonin nephropathy. J Altern Complement Med 1998; 4: 131-132

    PubMed  CAS  Google Scholar 

  48. McIntyre M. Chinese herbs: risk, side effects, and poisoning: the case for objective reporting and analysis reveals serious mis-representation. J Altern Complement Med 1998; 4: 15-16

    PubMed  CAS  Google Scholar 

  49. Colson CR, De Greef KE, Duymelinck C, Simoens PJ, Verpooten GA, De Broe ME. Role of serotonin in the development of Chinese herbs nephropathy? Nephrol Dial Transplant 1999; 14 Suppl 4: 16 (abstract)

    PubMed  Google Scholar 

  50. De Broe ME. On a nephrotoxic and carcinogenic slimming regimen. Am J Kidney Dis 1999; 33: 1171-1173

    PubMed  CAS  Google Scholar 

  51. Schmeiser HH, Bieler CA, Wiessler M, van Ypersele de Strihou C, Cosyns JP. Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res 1996; 56: 2025-2028

    PubMed  CAS  Google Scholar 

  52. Bieler CA, Stiborova M, Wiessler M, Cosyns JP, van Ypersele de Strihou C, Schmeiser HH. 32P-post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy. Carcinogenesis 1997; 18: 1063-1067

    PubMed  CAS  Google Scholar 

  53. Muniz Martinez MC, Nortier J, Vereerstraeten P, Vanherweghem JL. Progression rate of Chinese herb nephropathy: impact of Aristolochia fangchi ingested dose. Nephrol Dial Transplant 2002; 17: 408-412

    CAS  Google Scholar 

  54. Gillerot G, Jadoul M, Arlt VM, van Ypersele de Strihou C, Schmeiser HH, But PP, Bieler CA, Cosyns JP. Aristolochic acid nephropathy in a Chinese patient: time to abandon the term “Chinese herbs nephropathy”? Am J Kidney Dis 2001; 38: E26

    PubMed  CAS  Google Scholar 

  55. Vanherweghem JL, Cuykens JJ, Vandenbergh P, Bouman KP, Hagers Y. Valvular heart disease and Chinese-herb nephropathy. Lancet 1998; 351: 991

    Google Scholar 

  56. Debelle F, Nortier J, Arlt VM, De Prez E, Vienne A, Salmon I, Phillips DH, Deschodt-Lanckman M, Vanherweghem JL. Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy. Arch Toxicol 2003; 77: 218-226

    PubMed  CAS  Google Scholar 

  57. Stiborova M, Frei E, Wiessler M, Schmeiser HH. Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2. Chem Res Toxicol 2001; 14: 1128-1137

    PubMed  CAS  Google Scholar 

  58. Stiborova M, Frei E, Breuer A, Wiessler M, Schmeiser HH. Evidence for reductive activation of carcinogenic aristolochic acids by prostaglandin H synthase -- (32)P-postlabeling analysis of DNA adduct formation. Mutat Res 2001; 493: 149-160

    PubMed  CAS  Google Scholar 

  59. Schmeiser HH, Scherf HR, Wiessler M. Activating mutations at codon 61 of the c-Ha-ras gene in thin-tissue sections of tumors induced by aristolochic acid in rats and mice. Cancer Lett 1991; 59: 139-143

    PubMed  CAS  Google Scholar 

  60. Lebeau C, Arlt VM, Schmeiser HH, Boom A, Verroust PJ, Devuyst O, Beauwens R. Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells. Kidney Int 2001; 60: 1332-1342

    PubMed  CAS  Google Scholar 

  61. Cosyns JP, Goebbels RM, Liberton V, Schmeiser HH, Bieler CA, Bernard AM. Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats. Arch Toxicol 1998; 72: 738-743

    PubMed  CAS  Google Scholar 

  62. Cosyns JP, Dehoux JP, Guiot Y, Goebbels RM, Robert A, Bernard AM, van Ypersele de Strihou C. Chronic aristolochic acid toxicity in rabbits: A model of Chinese herbs nephropathy? Kidney Int 2001; 59: 2164-2173

    CAS  Google Scholar 

  63. Debelle FD, Nortier JL, de Prez EG, Garbar CH, Vienne AR, Salmon IJ, Deschodt-Lanckman MM, Vanherweghem JL. Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats. J Am Soc Nephrol 2002; 13: 431-436

    PubMed  CAS  Google Scholar 

  64. Debelle FD, Nortier JL, Husson CP, de Prez EG, Vienne AR, Rombaut K, Salmon IJ, Deschodt-Lanckman M, Vanherweghem JL. The renin-angiotensin system blockade does not prevent renal interstitial fibrosis induced by aristolochic acids. Kidney Int 2004; 66: 1815-1825

    PubMed  CAS  Google Scholar 

  65. Sato N, Takahashi D, Chen SM, Tsuchiya R, Mukoyama T, Yamagata S, Ogawa M, Yoshida M, Kondo S, Satoh N, Ueda S. Acute nephrotoxicity of aristolochic acids in mice. J Pharm Pharmacol 2004; 56: 221-229

    PubMed  CAS  Google Scholar 

  66. Balachandran P, Wei F, Lin RC, Khan IA, Pasco DS. Structure activity relationships of aristolochic acid analogues: toxicity in cultured renal epithelial cells. Kidney Int 2005; 67: 1797-1805

    PubMed  CAS  Google Scholar 

  67. Pozdzik AA, Salmon IJ, Debelle FD, Decaestecker C, Van den Branden C, Verbeelen D, Deschodt-Lanckman MM, Vanherweghem JL, Nortier JL. Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation. Kidney Int 2008; 73: 595-607

    PubMed  CAS  Google Scholar 

  68. Okada H, Watanabe Y, Inoue T, Kobayashi T, Kanno Y, Shiota G, Nakamura T, Sugaya T, Fukamizu A, Suzuki H. Transgene-derived hepatocyte growth factor attenuates reactive renal fibrosis in aristolochic acid nephrotoxicity. Nephrol Dial Transplant 2003; 18: 2515-2523

    PubMed  CAS  Google Scholar 

  69. Lebeau C, Debelle FD, Arlt VM, Pozdzik A, de Prez EG, Phillips DH, Deschodt-Lanckman MM, Vanherweghem JL, Nortier JL. Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies. Nephrol Dial Transplant 2005; 20: 2321-2332

    PubMed  Google Scholar 

  70. Liu MC, Maruyama S, Mizuno M, Morita Y, Hanaki S, Yuzawa Y, Matsuo S. The nephrotoxicity of Aristolochia manshuriensis in rats is attributable to its aristolochic acids. Clin Exp Nephrol 2003; 7: 186-194

    PubMed  CAS  Google Scholar 

  71. Hsin YH, Cheng CH, Tzen JT, Wu MJ, Shu KH, Chen HC. Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells. Apoptosis 2006; 11: 2167-2177

    PubMed  CAS  Google Scholar 

  72. Lee S, Lee T, Lee B, Choi H, Yang M, Ihm CG, Kim M. Fanconi‘s syndrome and subsequent progressive renal failure caused by a Chinese herb containing aristolochic acid. Nephrology (Carlton ) 2004; 9: 126-129

    Google Scholar 

  73. Arlt VM, Stiborova M, Schmeiser HH. Aristolochic acid as a probable human cancer hazard in herbal remedies: a review. Muta-genesis 2002; 17: 265-277

    CAS  Google Scholar 

  74. Vanherweghem JL. Urémie chronique et cancer des voies urinaires secondaires à la prise d’extraits végétaux utilisés en phy-tothérapie chinoise. Med Sciences 2003; 18: 1095-1101

    Google Scholar 

  75. Zhu M, Phillipson JD. Hong Kong samples of the traditional Chinese Medicine “Fang ji” contain aristolochic acid toxins. Int J Pharmacognosy 1996; 34: 283-289

    CAS  Google Scholar 

  76. Hashimoto K, Higuchi M, Makino B, Sakakibara I, Kubo M, Komatsu Y, Maruno M, Okada M. Quantitative analysis of aristolochic acids, toxic compounds, contained in some medicinal plants. J Ethnopharmacol 1999; 64: 185-189

    PubMed  CAS  Google Scholar 

  77. Vanherweghem JL. Aristolochia sp and chronic interstitial nephropathies in Indians. Lancet 1997; 349: 1399

    PubMed  CAS  Google Scholar 

  78. Grollman AP, Shibutani S, Moriya M, Miller F, Wu L, Moll U, Suzuki N, Fernandes A, Rosenquist T, Medverec Z, Jakovina K, Brdar B, Slade N, Turesky RJ, Goodenough AK, Rieger R, Vukelić M, Jelaković B. Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci 2007;104:12129-12134

    PubMed  CAS  Google Scholar 

  79. Debelle FD, Vanherweghem JL, Nortier JL. Aristolochic acid nephropathy: a worldwide problem. Kidney Int 2008; in press

    Google Scholar 

  80. Lewis CJ, Alpert S. Letter to health Care Professionals on FDA concerned about botanical products, including dietary supple-ments containing aristolochic acid. Us Food and Drug Administration - Center for Food Safety and Applied Nutrition - Office of Natritional Products. Labeling and Dietary supplements 2000; May 31

    Google Scholar 

  81. World Health Organization - International Agency for research on cancer: IARC monographs on the evaluation of carcinogenic risks to humans: some traditional herbal medicines, some mycotoxins, naphtalene and styrene. IARC Press, Lyon, France 2002; 82: 118

    Google Scholar 

  82. Wieland T. The toxic peptides from Amanita mushrooms. Int J Pept Protein Res 1983; 22: 257-276

    Article  PubMed  CAS  Google Scholar 

  83. Karlson-Stiber C, Persson H. Cytotoxic fungi--an overview. Toxicon 2003; 42: 339-349

    PubMed  CAS  Google Scholar 

  84. Jehl F, Gallion C, Birckel P, Jaeger A, Flesch F, Minck R. Determination of alpha-amanitin and beta-amanitin in human biological fluids by high-performance liquid chromatography. Anal Biochem 1985; 149: 35-42

    PubMed  CAS  Google Scholar 

  85. Jaeger A, Jehl F, Flesch F, Sauder P, Kopferschmitt J. Kinetics of amatoxins in human poisoning: therapeutic implications. J Toxicol Clin Toxicol 1993; 31: 63-80

    PubMed  CAS  Google Scholar 

  86. Mullins ME, Horowitz BZ. The futility of hemoperfusion and hemodialysis in Amanita phalloides poisoning. Vet Hum Toxicol 2000; 42: 90-91

    PubMed  CAS  Google Scholar 

  87. Enjalbert F, Rapior S, Nouguier-Soule J, Guillon S, Amouroux N, Cabot C. Treatment of amatoxin poisoning: 20-year retrospective analysis. J Toxicol Clin Toxicol 2002; 40: 715-757

    PubMed  CAS  Google Scholar 

  88. Danel VC, Saviuc PF, Garon D. Main features of Cortinarius spp. poisoning: a literature review. Toxicon 2001; 39: 1053-1060

    PubMed  CAS  Google Scholar 

  89. Prast H, Werner ER, Pfaller W, Moser M. Toxic properties of the mushroom Cortinarius orellanus. I. Chemical characterization of the main toxin of Cortinarius orellanus (Fries) and Cortinarius speciosissimus (Kuhn & Romagn) and acute toxicity in mice. Arch Toxicol 1988; 62: 81-88

    PubMed  CAS  Google Scholar 

  90. Bouget J, Bousser J, Pats B, Ramee MP, Chevet D, Rifle G, Giudicelli CP, Thomas R. Acute renal failure following collective intoxica-tion by Cortinarius orellanus. Intensive Care Med 1990; 16: 506-510

    PubMed  CAS  Google Scholar 

  91. Short AI, Watling R, MacDonald MK, Robson JS. Poisoning by Cortinarius speciosissimus. Lancet 1980; 2: 942-944

    PubMed  CAS  Google Scholar 

  92. Gryzmala S. Massenvergiftungen durch den orangefuchsigen Hautkopf. Z Pilzkd 1957; 23: 139-142

    Google Scholar 

  93. Mount P, Harris G, Sinclair R, Finlay M, Becker GJ. Acute renal failure following ingestion of wild mushrooms. Intern Med J 2002; 32: 187-190

    PubMed  CAS  Google Scholar 

  94. Montoli A, Confalonieri R, Colombo V. Lack of efficacy of early plasma exchange in renal toxicity from Cortinarius orellanus. Nephron 1999; 81: 248

    PubMed  CAS  Google Scholar 

  95. Calvino J, Romero R, Pintos E, Novoa D, Guimil D, Cordal T, Mardaras J, Arcocha V, Lens XM, Sanchez-Guisande D. Voluntary inges- tion of Cortinarius mushrooms leading to chronic interstitial nephritis. Am J Nephrol 1998; 18: 565-569

    PubMed  CAS  Google Scholar 

  96. O‘Donnell M, Fleming S. The renal pathology of mushroom poisoning. Histopathology 1997; 30: 280-282

    PubMed  Google Scholar 

  97. Rapior S, Delpech N, Andary C, Huchard G. Intoxication by Cortinarius orellanus: detection and assay of orellanine in biological fluids and renal biopsies. Mycopathologia 1989; 108: 155-161

    PubMed  CAS  Google Scholar 

  98. Kilner RG, D‘Souza RJ, Oliveira DB, MacPhee IA, Turner DR, Eastwood JB. Acute renal failure from intoxication by Cortinarius orel- lanus: recovery using anti-oxidant therapy and steroids. Nephrol Dial Transplant 1999; 14: 2779-2780

    PubMed  CAS  Google Scholar 

  99. Wornle M, Angstwurm MW, Sitter T. Treatment of intoxication with Cortinarius speciosissimus using an antioxidant therapy. Am J Kidney Dis 2004; 43: e3-e6

    PubMed  Google Scholar 

  100. de Haro L, Jouglard J, Arditti J, David JM. Insuffisance rénale aiguë lors d’intoxications par Amanita proxima: expérience du Centre anti-poisons de Marseille. Néphrologie 1998; 19: 21-24

    PubMed  CAS  Google Scholar 

  101. Leray H, Canaud B, Andary C, Klouche K, Beraud JJ, Mion C. Intoxication par Amanita proxima; une nouvelle cause d’insuffisance rénale aiguë. Néphrologie 1994; 15: 197-199

    PubMed  CAS  Google Scholar 

  102. Pelizarri V, Feifel E, Rohrmoser MM, Gstraunthaler G, Moser M. Partial purification and characterization of a toxic component of Amanita smithiana. Mycologia 1994; 86: 555-560

    Google Scholar 

  103. Yang WS, Lin CH, Huang JW, Fang CC. Acute renal failure caused by mushroom poisoning. J Formos Med Assoc 2006; 105: 263-267

    PubMed  CAS  Google Scholar 

  104. Leathem AM, Purssell RA, Chan VR, Kroeger PD. Renal failure caused by mushroom poisoning. J Toxicol Clin Toxicol 1997; 35: 67-75

    PubMed  CAS  Google Scholar 

  105. Bedry R, Baudrimont I, Deffieux G, Creppy EE, Pomies JP, Ragnaud JM, Dupon M, Neau D, Gabinski C, De WS, Chapalain JC, Godeau P, Beylot J. Wild-mushroom intoxication as a cause of rhabdomyolysis. N Engl J Med 2001; 345: 798-802

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nephrology Department, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, Brussels, 1070, Belgium

    Frédéric Debelle, Marie-Carmen Muniz-Martinez, Jean-Louis Vanherweghem & Joëlle Nortier

Authors
  1. Frédéric Debelle
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marie-Carmen Muniz-Martinez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jean-Louis Vanherweghem
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Joëlle Nortier
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratory of Pathophysiology Universiteitsplein 1, University of Antwerp, Wilrijk, B-2610, Belgium

    Marc E. De Broe

  2. Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR, 97201, USA

    George A. Porter

  3. Legacy Good Samaritan Hospital, 1015 NW 22nd Avenue, W004, Portland, OR, 97201, USA

    William M. Bennett

  4. Groupe Hôspitalier Pitié Salpétrière Service De Néphrologie 83, Boulevard de l′Hôpital, Paris, F-75013, France

    Gilbert Deray

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Debelle, F., Muniz-Martinez, MC., Vanherweghem, JL., Nortier, J. (2008). Herbal remedies containing aristolochic acid and mushroom nephrotoxicity. In: De Broe, M.E., Porter, G.A., Bennett, W.M., Deray, G. (eds) Clinical Nephrotoxins. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-84843-3_33

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-84843-3_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-84842-6

  • Online ISBN: 978-0-387-84843-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation