Proton pump inhibitors: acute interstitial nephritis and other renal effects
Proton pump inhibitors (PPIs) were introduced in 1989 with the development of omeprazole. Since then, they have become one of the most widely prescribed class of drugs on the market today. Over 43 million prescriptions were written for anti-ulcer therapy in the US in 2005 . Currently, there are five PPIs available in the United States and Europe: esomeprazole, lansoprazole, omeprazole, pantoprazole and rabeprazole. Their safety and efficacy profile is excellent, which has been the major factor leading to over 8 billion dollars in sales in 2005; a considerable sum given that omeprazole has been available since 2003 . However, renal complications do occur and it is important that they are recognized. Reported events include rare hyponatremia, drug-drug interactions and acute interstitial nephritis (AIN). There are, as of yet, no data on chronic interstitial disease resulting from these agents. However, it is certainly conceivable that long standing AIN may transition to chronic interstitial nephritis and end-stage renal disease.
KeywordsChronic Kidney Disease Proton Pump Inhibitor Calcineurin Inhibitor Interstitial Nephritis Nephrol Dial Transplant
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