Analgesics and 5-aminosalicylic acid

  • Monique M. Elseviers
  • Marc E. De Broe

Classic analgesic nephropathy is a slowly progressive disease resulting from the daily use for many years of analgesic mixtures containing at least two antipyretics, anilides and salicylates, and usually caffeine or codeine (or both). The nephropathy is characterized by renal papillary necrosis/calcifications and chronic interstitial nephritis, with an insidious progression to renal failure, sometimes in association with transitional-cell carcinoma of the uroepithelium [1-10]. This type of nephropathy has never been described after the intake of single analgesic substances. Analgesic nephropathy is a facultative part of a broad spectrum of clinical findings that is summarized as ‘analgesic syndrome’ (see below). Historically, these analgesic mixtures most frequently contained phenacetin in combination with a further analgesic and a centrally acting agent such as caffeine or codeine, which may lead to psychological dependence [11-15].


Inflammatory Bowel Disease Nephrol Dial Transplant Analgesic Consumption United States Renal Data System Analgesic Nephropathy 
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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Monique M. Elseviers
    • 1
  • Marc E. De Broe
    • 1
  1. 1.Faculty of Medicine Universiteitsplein 1University of AntwerpBelgium

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