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Antiviral agents

  • Jeffrey S. Berns
  • Alden Doyle
  • Nishaminy Kasbekar

The ability to prevent viral infections is becoming an increasingly important part of clinical medicine. The interest in the development of new antiviral agents and new uses of these medications is driven in large part by the treatment of human immunodeficiency virus (HIV) and growth of the field of transplantation. Although most of the use of these antiviral agents is well-tolerated by patients, there are a variety of potential kidney toxicities that should be appreciated. The most important of these toxicities is acute kidney injury (AKI), which is the main focus of this chapter. We will also consider fluid and electrolyte complications observed with these medications as well as other direct toxic effects on the kidneys. For information regarding clinical pharmacokinetics of antiviral agents and dosing guidelines for their use in patients with kidney injury, which are not discussed in detail here, the reader is referred to several recent reviews [1-5]. This discussion is limited to antiviral agents that are administered orally or parenterally only; topical and intraocular applications are not addressed. The nephrotoxicity of immunomodulatory agents that have anti-viral properties in vivo such as interferon alpha are discussed elsewhere.

Keywords

Human Immunodeficiency Virus Acute Kidney Injury Lactic Acidosis Antiviral Agent Nucleoside Reverse Transcriptase Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Jeffrey S. Berns
    • 1
  • Alden Doyle
    • 1
  • Nishaminy Kasbekar
    • 1
  1. 1.Renal-Electrolyte and Hypertension DivisionUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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