Mitochondrial Respiration and Differentiation
Cell differentiation is the process by which a progenitor cell progressively matures to assume its final morphology and function. Numerous signal transduction pathways contribute to this complex process, and many of these signal transduction pathways and their abnormalities are fundamental to the development and pathogenesis of cancer. Lack of differentiation (i.e., dedifferentiation, retro-differentiation, or anaplasia) is a morphological hallmark of malignant transformation and implies a reversion from a high level of differentiation to a lower level. The degree of dedifferentiation differs among cancers, and is often correlated to malignancy.
KeywordsMitochondrial Respiration NADH Dehydrogenase Clofibric Acid Fumarate Hydratase PPAR Ligand
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