Skip to main content

Mitochondria and Oncocytomas

  • Chapter
  • First Online:
Mitochondria and Cancer

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Alchanati, I., Nallar, S. C., Sun, P., Gao, L., Hu, J., Stein, A., Yakirevich, E., Konforty, D., Alroy, I., Zhao, X., Reddy, S. P., Resnick, M. B., and Kalvakolanu, D. V. 2006. A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Oncogene 25:7138–7147.

    Article  CAS  PubMed  Google Scholar 

  • Angell, J. E., Lindner, D. J., Shapiro, P. S., Hofmann, E. R., and Kalvakolanu, D. V. 2000. Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach. J. Biol. Chem. 275:33416–33426.

    Article  CAS  PubMed  Google Scholar 

  • Apel R. L. and Asa S. L. 2002. The parathyroid glands. In LiVolsi and V. Asa S. L. Endocrine Pathology, Churchill Livingstone.Philadelphia, PA: 103–137.

    Google Scholar 

  • Attardi, G., Yoneda, M., and Chomyn, A. 1995. Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems. Biochim Biophys Acta 1271:241–248.

    PubMed  Google Scholar 

  • Ballinger, S. W., Bouder, T. G., Davies, G. S., Judice, S. A., Nicklas, J. A., and Albertini, R. J. 1996. Mitochondrial genome damage associated with cigarette smoking. Cancer Res. 56:5692–5697.

    CAS  PubMed  Google Scholar 

  • Baris, O., Savagner, F., Nasser, V., Loriod, B., Granjeaud, S., Guyetant, S., Franc, B., Rodien, P., Rohmer, V., Bertucci, F., Birnbaum, D., Malthiery, Y., Reynier, P., and Houlgatte, R. 2004. Transcriptional profiling reveals coordinated up-regulation of oxidative metabolism genes in thyroid oncocytic tumors. J. Clin. Endocrinol. Metab. 89:994–1005.

    Article  CAS  PubMed  Google Scholar 

  • Bonora, E., Evangelisti, C., Bonichon, F., Tallini, G., and Romeo, G. 2006a. Novel germline variants identified in the inner mitochondrial membrane transporter TIMM44 and their role in predisposition to oncocytic thyroid carcinomas. Br. J. Cancer 95:1529–1536.

    Article  CAS  Google Scholar 

  • Bonora, E., Porcelli, A. M., Gasparre, G., Biondi, A., Ghelli, A., Carelli, V., Baracca, A., Tallini, G., Martinuzzi, A., Lenaz, G., Rugolo, M., and Romeo, G. 2006b. Defective oxidative phosphorylation in thyroid oncocytic carcinoma is associated with pathogenic mitochondrial DNA mutations affecting complexes I and III. Cancer Res. 66:6087–6096.

    Article  CAS  Google Scholar 

  • Brooks, J. D., Marshall, F. F., Isaacs, W. B., and Johns, D. R. 1999. Absence of HinfI Restriction Abnormalities in Renal Oncocytoma Mitochondrial DNA. Mol. Urol. 3:1–3.

    CAS  PubMed  Google Scholar 

  • Canzian, F., Amati, P., Harach, H. R., Kraimps, J. L., Lesueur, F., Barbier, J., Levillain, P., Romeo, G., and Bonneau, D. 1998. A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2. Am. J. Hum. Genet. 63:1743–1748.

    Article  CAS  PubMed  Google Scholar 

  • Czarnecka, A. M., Golik, P., and Bartnik, E. 2006. Mitochondrial DNA mutations in human neoplasia. J. Appl.Genet. 47:67–78.

    PubMed  Google Scholar 

  • Dai, J. G., Xiao, Y. B., Min, J. X., Zhang, G. Q., Yao, K., and Zhou, R. J. 2006. Mitochondrial DNA 4977 BP deletion mutations in lung carcinoma. Ind. J. Cancer 43:20–25.

    Article  Google Scholar 

  • DeLellis, R. A., Lloyd, R. V., Heitz, P. U., and Eng, C. 2004. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Endocrine Organs. IARC press.Lyon:

    Google Scholar 

  • Eng, C., Kiuru, M., Fernandez, M. J., and Aaltonen, L. A. 2003. A role for mitochondrial enzymes in inherited neoplasia and beyond. Nat. Rev. Cancer. 3:193–202.

    Article  CAS  PubMed  Google Scholar 

  • Erickson, L. A., Jin, L., Papotti, M., and Lloyd, R. V. 2005. Oxyphil parathyroid carcinomas: a clinicopathologic and immunohistochemical study of 10 cases. Am. J. Surg. Pathol. 26:344–349.

    Article  Google Scholar 

  • Farrand, K., Delahunt, B., Wang, X. L., McIver, B., Hay, I. D., Goellner, J. R., Eberhardt, N. L., and Grebe, S. K. 2002. High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common region of allelic imbalance, probably containing a novel tumor suppressor gene. J. Clin. Endocrinol. Metab. 87:4715–4721.

    Article  CAS  PubMed  Google Scholar 

  • Frisk, T., Kytola, S., Wallin, G., Zedenius, J., and Larsson, C. 1999. Low frequency of numerical chromosomal aberrations in follicular thyroid tumors detected by comparative genomic hybridization. Genes Chromosomes Cancer 25:349–353.

    Article  CAS  PubMed  Google Scholar 

  • Gasparre, G., Porcelli, A. M., Bonora, E., Pennisi, L. F., Toller, M., Iommarini, L., Ghelli, A., Moretti, M., Betts, C. M., Martinelli, G. M., Ceroni, A. R., Curcio, F., Carelli, V., Rugolo, M., Tallini, G., and Romeo, G. 2007. Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors. Cancer Res. 104:9001–9006.

    CAS  Google Scholar 

  • Giorgadze, T., Stratton, B., Baloch, Z. W., and LiVolsi, V. A. 2004. Oncocytic parathyroid adenoma: problem in cytological diagnosis. Diagn. Mol. Pathol. 31:276–280.

    Google Scholar 

  • Gottlieb, E. and Tomlinson, I. P. 2005. Mitochondrial tumour suppressors: a genetic and biochemical update. Nat. Rev. Cancer 5:857–866.

    Article  CAS  PubMed  Google Scholar 

  • Hamperl, H. 1962. Benign and malignant oncocytoma. Cancer. 15:1019–1027.

    Article  CAS  PubMed  Google Scholar 

  • Heddi, A., Faure-Vigny, H., Wallace, D. C., and Stepien, G. 1996. Coordinate expression of nuclear and mitochondrial genes involved in energy production in carcinoma and oncocytoma. Biochim. Biophys. Acta. 1316:203–209.

    PubMed  Google Scholar 

  • Jacques, C., Baris, O., Prunier-Mirebeau, D., Savagner, F., Rodien, P., Rohmer, V., Franc, B., Guyetant, S., Malthiery, Y., and Reynier, P. 2005. Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors. J. Clin. Endocrinol. Metab. 90:2314–2320.

    Article  CAS  PubMed  Google Scholar 

  • Kepes, J. J. 1983. Oncocytic transformation of choroid plexus epithelium. Acta Neuropathol. 63:145–148.

    Article  Google Scholar 

  • Lewis, P. D., Baxter, P., Paul Griffiths, A., Parry, J. M., and Skibinski, D. O. 2000. Detection of damage to the mitochondrial genome in the oncocytic cells of Warthin's tumour. J. Pathol. 191:274–281.

    Article  CAS  PubMed  Google Scholar 

  • Lewis, P. D., Fradley, S. R., Griffiths, J. R., Baxter, P. W., and Parry, J. M. 2002. Mitochondrial DNA mutations in the parotid gland of cigarette smokers and non-smokers. Mutat. Res. 518:47–54.

    CAS  PubMed  Google Scholar 

  • Lindal, S., Lund, I., Torbergsen, T., Aasly, J., Mellgren, S. I., Borud, O., and Monstad, P. 1992. Mitochondrial diseases and myopathies: a series of muscle biopsy specimens with ultrastructural changes in the mitochondria. Ultrastruct. Pathol. 16:263–275.

    Article  CAS  PubMed  Google Scholar 

  • Maximo, V. and Sobrinho-Simoes, M. 2000a. Hurthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance. Virchows Arch. 437:107–115.

    Article  CAS  Google Scholar 

  • Maximo, V. and Sobrinho-Simoes, M. 2000b. Mitochondrial DNA ‘common’ deletion in Hurthle cell lesions of the thyroid. J. Pathol. 192:561–562.

    Article  CAS  Google Scholar 

  • Maximo, V., Sores, P., Rocha, A. S., and Sobrinho-Simoes, M. 1998. The common deletion of mitochondrial DNA is found in goiters and thyroid tumors with and without oxyphil cell change. Ultrastruct. Pathol. 22:271–273.

    Article  CAS  PubMed  Google Scholar 

  • Maximo, V., Soares, P., Lima, J., Cameselle-Teijeiro, J., and Sobrinho-Simoes, M. 2002. Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hurthle cell tumors. Am. J. Pathol. 160:1857–1865.

    CAS  PubMed  Google Scholar 

  • Maximo, V., Preto, A., Crespo, A., Rocha, A. S., Machado, J. C., Soares, P., and Sobrinho-Simoes, M. 2004. Core I gene is overexpressed in Hurthle and non-Hurthle cell microfollicular adenomas and follicular carcinomas of the thyroid. BMC Cancer 25:4–12.

    Google Scholar 

  • Maximo, V., Botelho, T., Capela, J., Soares, P., Lima, J., Taveira, A., Amaro, T., Barbosa, A. P., Preto, A., Harach, H. R., Williams, D., and Sobrinho-Simoes, M. 2005a. Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. Br J Cancer 92:1892–1898.

    Article  CAS  Google Scholar 

  • Maximo, V., Lima, J., Soares, P., Botelho, T., Gomes, L., and Sobrinho-Simoes, M. 2005b. Mitochondrial D-Loop instability in thyroid tumours is not a marker of malignancy. Mitochondrion 5:333–340.

    Article  CAS  Google Scholar 

  • MITOMAP: A Human Mitochondrial Genome Database, 2007.http://www.mitomap.org..

  • Muller-Hocker, J. 1992. Random cytochrome-C-oxidase deficiency of oxyphil cell nodules in the parathyroid gland. A mitochondrial cytopathy related to cell ageing? Pathol. Res. Pract. 188:701–706.

    CAS  Google Scholar 

  • Muller-Hocker, J., Aust, D., Napiwotsky, J., Münscher, C., Link, T. A., Seibel, P., Schneeweiss, S. G., and Kadenbach, B. 1996. Defects of the respiratory chain in oxyphil and chief cells of the normal parathyroid and in hyperfunction. Hum. Pathol. 27:532–541.

    Article  CAS  PubMed  Google Scholar 

  • Nesland, J. M., Sobrinho-Simoes, M. A., Holm, R., Sambade, M. C., and Johannessen, J. V. 1985. Hurthle-cell lesions of the thyroid: a combined study using transmission electron microscopy, scanning electron microscopy, and immunocytochemistry. Ultrastruct. Pathol. 8:269–290.

    Article  CAS  PubMed  Google Scholar 

  • Ohama, E. and Ikuta, F. 1987. Involvement of choroid plexus in mitochondrial encephalomyopathy (MELAS). Acta Neuropathol. 75:1–7.

    Article  CAS  PubMed  Google Scholar 

  • Pavlovich, C. P., Walther, M. M., Eyler, R. A., Hewitt, S. M., Zbar, B., Linehan, W. M., and Merino, M. J. 2002. Renal tumors in the Birt–Hogg–Dubé syndrome. Am. J. Surg. Pathol. 26:1542–1552.

    Article  PubMed  Google Scholar 

  • Sanchez-Cespedes, M., Parrella, P., Nomoto, S., Cohen, D., Xiao, Y., Esteller, M., Jeronimo, C., Jordan, R. C., Nicol, T., Koch, W. M., Schoenberg, M., Mazzarelli, P., Fazio, V. M., and Sidransky, D. 2001. Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors. Cancer Res. 61:7015–7019.

    CAS  PubMed  Google Scholar 

  • Savagner, F., Franc, B., Guyetant, S., Rodien, P., Reynier, P., and Malthiery, Y. 2001. Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors. J. Clin. Endocrinol. Metab. 86:4920–4925.

    Article  CAS  PubMed  Google Scholar 

  • Sengers, R. C., Stadhouders, A. M., and Trijbels, J. M. 1984. Mitochondrial myopathies. Clinical, morphological and biochemical aspects. Eur. J. Pediatr. 141:192–207.

    Article  CAS  PubMed  Google Scholar 

  • Simonnet, H., Alazard, N., Gallou, C., Béroud, C., Demont, J., Bouvier, R., Schägger, H., and Godinot, C. 2002. Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma. Carcinogenesis 23:759–768.

    Article  CAS  PubMed  Google Scholar 

  • Simonnet, H., Demont, J., Pfeiffer, K., Guenaneche, L., Bouvier, R., Brandt, U., Schagger, H., and Godinot, C. 2003. Mitochondrial complex I is deficient in renal oncocytomas. Carcinogenesis 24:1461–1466.

    Article  CAS  PubMed  Google Scholar 

  • Sobrinho-Simoes, M., Maximo, V., Castro, I. V., Fonseca, E., Soares, P., Garcia-Rostan, G., and Oliveira, M. C. 2005. Hurthle (oncocytic) cell tumors of thyroid: etiopathogenesis, diagnosis and clinical significance. Int. J. Surg. Pathol. 13:29–35.

    Article  PubMed  Google Scholar 

  • Sobrinho-Simoes, M. A., Nesland, J. M., Holm, R., Sambade, M. C., and Johannessen, J. V. 1985. Hurthle cell and mitochondrion-rich papillary carcinomas of the thyroid gland: an ultrastructural and immunocytochemical study. Ultrastruct. Pathol. 8:131–142.

    Article  CAS  PubMed  Google Scholar 

  • Tallini, G., Hsueh, A., Liu, S., Garcia-Rostan, G., Speicher, M. S., and Ward, D. C. 1999. Frequent chromosomal DNA unbalance in thyroid oncocytic (Hürthle cell) neoplasms detected by comparative genomic hybridization. Lab. Invest. 79:547–555.

    CAS  PubMed  Google Scholar 

  • Tallini, G., Ladanyi, M., Rosai, J., and Jhanwar, S. C. 1994. Analysis of nuclear and mitochondrial DNA alterations in thyroid and renal oncocytic tumors. Cytoget. Cell Genet. 66:253–259.

    Article  CAS  Google Scholar 

  • Tanji, K., Schon, E. A., DiMauro, S., and Bonilla, E. 2000. Kearns-sayre syndrome: oncocytic transformation of choroid plexus epithelium. J. Neurol. Sci. 178:29–36.

    Article  CAS  PubMed  Google Scholar 

  • Taylor, R. W. and Turnbull, D. M. 2005. Mitochondrial DNA mutations in human disease. Nat. Rev. Genet. 6:389–402.

    Article  CAS  PubMed  Google Scholar 

  • Wada, N., Duh, Q. Y., Miura, D., Brunaud, L., Wong, M. G., and Clark, O. H. 2002. Chromosomal aberrations by comparative genomic hybridization in hürthle cell thyroid carcinomas are associated with tumor recurrence. J. Clin. Endocrinol. Metab. 87:4595–4601.

    Article  CAS  PubMed  Google Scholar 

  • Welter, C., Kovacs, G., Seitz, G., and Blin, N. 1989. Alteration of mitochondrial DNA in human oncocytomas. Genes Chromosomes Cancer 1:79–82.

    Article  CAS  PubMed  Google Scholar 

  • Zambrano, N. R., Lubensky, I. A., Merino, M. J., Linehan, W. M., and Walther, M. M. 1999. Histopathology and molecular genetics of renal tumors toward unification of a classification system. J. Urol. 162:1246–1258.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J. Lima .

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science + Business Media, LLC

About this chapter

Cite this chapter

Lima, J., Máximo, V., Soares, P., Portugal, R., Guimarães, S., Sobrinho-Simões, M. (2009). Mitochondria and Oncocytomas. In: Mitochondria and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84835-8_11

Download citation

Publish with us

Policies and ethics