Mitochondria and Oncocytomas

  • J. Lima
  • V. Máximo
  • P. Soares
  • R. Portugal
  • S. Guimarães
  • M. Sobrinho-Simões

Oncocytic Tumors and Oncocytomas

The designation oncocytoma was coined by Hamperl (1962) to describe a tumor composed by “oncocytes.” Oncocyte is a descriptive term for a neoplastic or nonneoplastic cell stuffed with mitochondria that give a grainy, eosinophilic appearance to its swollen cytoplasm. In many instances, oxyphilic transformation is used as a synonym for oncocytic transformation, thus leading to the utilization of oxyphilic tumor as a synonym for oncocytic tumor or oncocytoma. In the thyroid, other terms are used: Hürthle cell transformation and Hürthle cell tumors (Nesland et al.1985; Sobrinho-Simoes et al.1985,2005). Finally, there are, in some organs, tumors composed by oncocytes that carry specific designations (e.g. Warthin's tumor of the salivary glands).

In this chapter we will only focus on neoplastic oncocytes, i.e., on the tumors – oncocytomas – composed by such cells, but they may also occur in several “normal” organs of elderly patients (e.g. parathyroid...


Parathyroid Adenoma Renal Cell Carcinoma Renal Oncocytomas OXPHOS Complex Oncocytic Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • J. Lima
    • 1
  • V. Máximo
    • 1
    • 2
  • P. Soares
    • 1
    • 2
  • R. Portugal
    • 3
  • S. Guimarães
    • 3
  • M. Sobrinho-Simões
    • 1
    • 2
    • 3
  1. 1.Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)PortoPortugal
  2. 2.Department of PathologyMedical Faculty of University of PortoPortoPortugal
  3. 3.Department of PathologyHospital S. JoãoPortoPortugal

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