Malignant Adnexal Neoplasms

  • Ryan S. Jawitz
  • Jack C. Jawitz


Malignant adnexal neoplasms are rare tumors derived from apocrine, eccrine, sebaceous and follicular adnexal structures. Herein, the malignant tumors of eccrine differentiation will be reviewed. The histological features that distinguish these neoplasms from each other and from benign tumors, as well as the features that are found when these tumors locally invade neighboring tissue and/or metastasize, are discussed.


Basal Cell Carcinoma Adenoid Cystic Carcinoma Ductal Differentiation Microcystic Adnexal Carcinoma Dermal Nodule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Breiting L, Christensen L, Dahlstrom K, et al. Primary Mucinous Carcinoma of the skin: a population-based study. Int J Dermatol. 2008;47:242–245.CrossRefPubMedGoogle Scholar
  2. 2.
    James WD, Berger T, Elston DM. Andrews Diseases of the Skin Clinical Dermatology. 10th ed. Toronto: Saunders; 2006.Google Scholar
  3. 3.
    Ko CJ, Cochran AJ, Eng W, et al. Hidradenocarcinoma: a histologial and immunohistochemical study. J Cutan Pathol. 2006;33:726–730.CrossRefPubMedGoogle Scholar
  4. 4.
    Naylor E, Sarkar P, Perlis CS, et al. Primary cutaneous Adenoid Cystic Carcinoma. J Am Acad Dermatol. 2008;58:636–641.CrossRefPubMedGoogle Scholar
  5. 5.
    Nishizawa A, Nakanishi Y, Sasajima Y, et al. Syringoid Eccrine Carcinoma with apparently aggressive transformation: case report and review of the literature. Int J Dermatol. 2006;45:1212–1221.CrossRefGoogle Scholar
  6. 6.
    Pozo L, Camacho F, Rios-Martin JJ, et al. Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic applications. J Cutan Pathol. 2000;27:292–297.CrossRefPubMedGoogle Scholar
  7. 7.
    Ramos D, Monteagudo C, Carda C, et al. Clear cell syringoid carcinoma: an ultrastructural and immunohistochemical study. Am J Dermatopathol. 2000;22:60–64.CrossRefPubMedGoogle Scholar
  8. 8.
    Rapini RP. Practical Dermatopathology. London: Elsevier; 2005.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ryan S. Jawitz
    • 1
    • 2
  • Jack C. Jawitz
    • 3
  1. 1.Lake Erie College of Osteopathic Medicine, Manatee Memorial HospitalBradentonUSA
  2. 2.Department of MedicineLargo Medical CenterLargoUSA
  3. 3.Department of MedicineLake Erie College of Osteopathic Medicine, Manatee Memorial HospitalBradentonUSA

Personalised recommendations