Melanocyte Pathology

  • Michael B. Morgan


  • EPIDEMIOLOGY: Common, 1/20 incidence of basal cell carcinoma.

  • PATHOGENISIS: UV light, p-53, C- kit, p16 Braf/ras/erk genetic defects.

  • CLINICAL: Irregular hyperpigmented patch on sun-exposed site.


Basal Cell Carcinoma Invasive Melanoma Ultraviolet Exposure Atypical Nevus Pagetoid Scatter 
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  1. 1.
    Agarwal N, Bowen G, Gervels J. Histologic assessment of lentigo-maligna with permanent sections: Implications regarding current guidelines. JAAD. 2002;47:743.Google Scholar
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    Flotte T. Malignant melanoma in situ. Hum Pathol. 1990;221:1199.CrossRefPubMedGoogle Scholar
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    Shabrawi L, Kerl H, Cerroni L. Melan-A is not helpful marker in the distinction between melanoma in situ on sun damaged skin and pigmented actinic keratosis. Am J Dermatopathol. 2004;26:364.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Michael B. Morgan
    • 1
  1. 1.Bay Area Dermatopathology Ameripath, and Director of Primary Care Institute, Dermpath DiagnosticsUniversity of South Florida College of Medicine, and Director, Dermatopathology, Haley V.A. Hospital, and Managing DirectorTampaUSA

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