Paget’s Disease

  • Michael B. Morgan


  • EPIDEMIOLOGY: Uncommon, elderly, mammary and extra-mammary.

  • ETIOLOGY: Unknown

  • PATHOLOGY: Single and nested clear cells throughout the epithelium, CEA+, CK-7+, EMA+.

  • CLINICAL: Scaly or erythematous patch areola or genitalia.

  • TREATMENT: Supportive for mammary, excision with genitourinary/gastrointestinal w/u for extra-mammary.


Squamous Cell Carcinoma Cell Leukocyte Common Antigen Mohs Micrographic Surgery Erythematous Patch Visceral Malignancy 


  1. 1.
    Chanda J. Extramammary pagets disease: prognosis and relationship to internal malignancy. JAAD. 1985;13:1009.Google Scholar
  2. 2.
    Jones R, Austin C, Ackerman A. Extramammary pagets disease: a critical reexamination. Am J Dermatopathol. 1979;1:101.CrossRefPubMedGoogle Scholar
  3. 3.
    Lee S, Roth L, Ehrlich C, et al. Extramammary pagets disease of the vulva. A clinicopathologic study of 13 cases. Cancer. 1977;39:2540.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Michael B. Morgan
    • 1
  1. 1.Bay Area Dermatopathology Ameripath, and Director of Primary Care Institute, Dermpath DiagnosticsUniversity of South Florida College of Medicine, and Director, Dermatopathology, Haley V.A. Hospital, and Managing DirectorTampaUSA

Personalised recommendations