Abstract
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EPIDEMIOLOGY : Uncommon, approximately 1/2 occur on eyelids, elderly with equal gender, syndromic females are at a younger age.
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PATHOGENESIS : Derive from Meibomian glands, other sebaceous glands, assoc. with XRT and Muir-Torre Syndrome.
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PATHOLOGY: Pagetoid or invasive basaloid or squamous cells with sebocytic cells showing clear cytoplasmic vacuoles.
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CLINICAL : Non-descript ulcerating papule, may be yellow in appearance or involve both eyelids.
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PROGNOSIS : Poor with 25% patients with metastatic disease at diagnosis with 50% 5-year mortality, lymph nodes.
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Bibliography
Nelson B, Hamlet K, Hillard M, et al. Sebaceous carcinoma. JAAD. 1995; 33: 1.
Rao N, Hidayat A, McClean I, et al. sebaceous carcinoma of the ocular adnexae: a clinicopathalogic study of 104 cases, with 5 year follow up. Hum Pathol. 1982; 13: 113.
Schwartz R, Torre D. The Muir-Torre syndrome: a 25-year retrospect. JAAD. 1995;33: 90.
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Morgan, M.B. (2010). Sebaceous Tumors. In: Morgan, M., Hamill, J., Spencer, J. (eds) Atlas of Mohs and Frozen Section Cutaneous Pathology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84800-6_11
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DOI: https://doi.org/10.1007/978-0-387-84800-6_11
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