Risk Factors for Thrombosis in Cancer Patients

Part of the Cancer Treatment and Research book series (CTAR, volume 148)

Venous thromboembolism (VTE), comprised of deep vein thrombosis (DVT) and its complication, pulmonary embolism (PE), is a multifactorial disease, involving complex interactions between environmental exposures and patients, including their hemostatic system and genetic predispositions. VTE is relatively common, with an overall average age- and sex-adjusted incidence of about 1.04–1.9 per 1000 person-years that rises dramatically with increasing age [1–4]. Active malignancy accounts for almost 20% of incident VTE events occurring in the community [5], and imparts a 4- to 6.5-fold higher VTE risk compared to non-cancer patients, depending on concurrent use of anti-cancer therapy [6]. The risk of VTE also varies by cancer type and stage [7–10]. The association between VTE and malignancy has been recognized since 1861 when Trousseau, in a lecture, described thrombophlebitis as the presenting sign of visceral malignancy [11].


Polycythemia Vera Essential Thrombocythemia JAK2 V617F Factor Versus Leiden Mutation Thrombin Activatable Fibrinolysis Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Division of Hematology, Department of Internal MedicineCollege of Medicine, Mayo ClinicRochesterUSA
  2. 2.Dept of Hematology ResearchMayo ClinicRochesterUSA

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