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Chemotherapy-Associated Thrombosis

  • Aneel A. Ashrani
  • S. Vincent Rajkumar
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 148)

Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a multifactorial disease, involving complex interactions between individuals (including their hemostatic system and genetic predispositions) and their environmental exposures. Active malignancy is a well recognized risk factor for VTE and accounts for almost 20% of incident VTE events occurring in the community [1], with chemotherapy independently adding to that risk [2, 3]. As compared with the general population, the risk of VTE is increased fourfold in patients with cancer and this risk is further elevated to more than sixfold when these patients are receiving chemotherapy [2]. Moreover, there is a twofold increase in recurrent VTE in patients with malignancy and a fourfold increase in this risk for those receiving chemotherapy [2]. In addition, the risk of VTE varies by cancer type and stage [3–6]. The type of chemotherapy administered, hormonal treatments, immunomodulating and anti-angiogenesis agents (e.g., thalidomide, lenalidomide, bevacizumab), and supportive therapy with hematopoietic growth factors like recombinant human erythropoietins have been implicated in alterations in hemostasis and with increased VTE risk.

Keywords

Multiple Myeloma Polycythemia Vera Essential Thrombocythemia Recombinant Human Erythropoietin Gemtuzumab Ozogamicin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Division of Hematology, Department of Internal MedicineCollege of Medicine, Mayo ClinicRochesterUSA
  2. 2.Div of HematologyMayo Clinic College of Med.Rochester

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