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Persistence of West Nile Virus Infection in Vertebrates

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West Nile Encephalitis Virus Infection

Part of the book series: Emerging Infectious Diseases of the 21 Century ((EIDC))

Abstract

This chapter reviews the experimental evidence for persistence of West Nile virus (WNV) in vertebrates. Results of studies in monkeys, hamsters, and birds all indicate that WNV can produce an asymptomatic persistent infection in immune competent vertebrates. In the case of hamsters, the most thoroughly studied model, the infected animals develop a persistent renal infection with chronic shedding of WNV in their urine. Similar reports with a diverse group of other flaviviruses suggest that persistent infection is not a rare phenomenon and that it may be a general characteristic of viruses in this genus.

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Acknowledgments

This work was supported by contracts NO1-AI25489 and NO1-AI30027 from the National Institutes of Health.

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Authors and Affiliations

  1. Department of Pathology Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch Galveston, TX, USA

    Robert B. Tesh & Shu-Yuan Xiao

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  1. Robert B. Tesh
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  2. Shu-Yuan Xiao
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Tesh, R.B., Xiao, SY. (2009). Persistence of West Nile Virus Infection in Vertebrates. In: West Nile Encephalitis Virus Infection. Emerging Infectious Diseases of the 21st Century. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79840-0_16

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