Pneumococcal Conjugate Vaccines Probe Studies: The Solution Points to the Problem

  • Ron Dagan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 634)

Observed Versus Expected Effect of a Vaccine – The Vaccine Probe Concept

Understanding the effect of vaccines must include information derived from earlier studies (Phase I and Phase II), efficacy studies (Phase III), and data derived after introduction of the vaccines. When information is accumulated, one needs to assess to compare the ‘observed effects’ with what was expected from the vaccine (‘expected effects’). Observed effects can be divided schematically into five components (1) Observed outcomes that were expected to occur; (2) observed outcomes where no prevaccination estimates could be calculated, but some effect was still expected; (3) effect in contacts of vaccinees through herd immunity; (4) unexpected beneficial outcomes; and (5) unexpected deleterious effects. The term ‘vaccine probe’ is used to describe an attempt to understand pathogenesis, epidemiology, and disease burden through observing unexpected or unpredictable responses to vaccines.

When this approach is...


Acute Otitis Medium Lower Respiratory Infection Invasive Pneumococcal Disease Pneumococcal Pneumonia Herd Immunity 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Pediatric Infectious Disease UnitSoroka University Medical CenterIsrael

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