How Can We Eradicate Pertussis

  • James D. Cherry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 634)


In comparison with other vaccine-preventable diseases, pertussis presents many unique challenges (see Cherry and Heininger, in press). Pertussis occurs in all age groups and immunity following natural disease or vaccination is not long lasting.

Bordetella pertussis: The Organism and Its Pathogenesis

Since its first isolation in 1906 Bordetella pertussis has fascinated microbiologists because it contains many toxins and surface proteins (adhesins), antibody to which might be important in protection (see Mattoo and Cherry, 2005). In general, steps in bacteria pathogenesis involve the following: entry into the host and attachment; evasion or disruption of host defenses; development of damage at the infection site; and establishment of systematic disease by dissemination of organisms or their products. Presented in Table 1 are selected toxins and surface proteins of B. pertussis.
Table 1

Selected virulence factors of Bordetella pertussis


Pertussis toxin (PT)



Pertussis Toxin Pertussis Vaccine Bordetella Pertussis Acellular Pertussis Vaccine Pertussis Infection 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of PediatricsDavid Geffen School of Medicine at UCLALos AngelesUSA

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