Current Concepts of the Pathogenesis of RSV Bronchiolitis

  • Louis Bont
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 634)


The respiratory syncytial virus (RSV) is a member of the Pneumovirus genus within the family Paramyxoviridae. The RSV has a 15-kb-long, single-stranded, negative-sense RNA genome, encoding 11 genes. These include the immunodominant attachment-(G) and fusion (F) proteins at the surface of the virion and the matrix (M) protein and the immunomodulatory non-structural (NS1/NS2) proteins.

RSV bronchiolitis is the leading cause of infant hospitalization during the winter season. It is not known why RSV infections do not occur during the summer. There is evidence that the incidence of RSV infections is increased during periods of low ultraviolet B radiance (Yusuf et al., 2007). Practically all children are infected with RSV before the age of 2 years, but only a minority develop severe disease requiring hospital admission. It is estimated that 10% of infants hospitalized for RSV require mechanical ventilation (Bont and Kimpen, 2002; Simoes, 1999; Smyth and Openshaw, 2006). With...


Respiratory Syncytial Virus Innate Immune System Single Nucleotide Polymorphism Respiratory Syncytial Virus Infection Severe Respiratory Syncytial Virus 
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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department Pediatric Infectious DiseasesUniversity Medical Center Utrecht, Rm KE4.133.13508 AB Utrecht

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