Febrile Neutropenia in Children with Cancer

  • Stéphane Paulus
  • Simon Dobson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 634)


Febrile neutropenia (FN) is a common complication in children treated for malignancies. In this review, we describe recent advances in several aspects of this topic at the crossroads between oncology and infectious diseases. Although a large amount of information on the subject comes from the adult literature, we have tried to integrate information from paediatric series when this data were available.


A recent article has highlighted the lack of an agreed definition of fever, and the variability amongst units caring for children with cancer (Phillips B., et al., 2007). The Infectious Diseases Society of America 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer defines fever as a single oral temperature of 38.3°C, or 38.0°C twice at least 1 h apart (Hughes et al., 2002). Neutropenia is defined as an absolute neutrophil count (ANC) of less than 500 cells/µL, or less than 1000 cells/µL in a patient anticipated to rapidly...


Febrile Neutropenia Invasive Aspergillosis Minimal Inhibitory Concentration Haematopoietic Stem Cell Transplantation Invasive Pulmonary Aspergillosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.British Columbia Children’s Hospital4480 Oak StreetVancouverCanada

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