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Influenza in Pregnancy: The Case for Prevention

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References

  • Acs N, Banhidy F, Puho E, Czeizel AE (2005). Maternal influenza during pregnancy and risk of congenital abnormalities in offspring. Birth Defects Res A Clin Mol Teratol, 73: 989–996.

    Article  PubMed  CAS  Google Scholar 

  • American Lung Association Asthma Clinical Research Centers (2001). The safety of inactivated influenza vaccine in adults and children with asthma. N Engl J Med, 345: 1529–1536.

    Article  Google Scholar 

  • Aro T, Haapakoski J, Heinonen OP (1984). A multivariate analysis of the risk indicators of reduction limb defects. Int J Epidemiol, 13: 459–464.

    Article  PubMed  CAS  Google Scholar 

  • Black SB, Shinefield HR, France EK, Fireman BH, Platt ST, Shay D (2004). Vaccine Safety Datalink Workgroup: Effectiveness of influenza vaccine during pregnancy in preventing hospitalizations and outpatient visits for respiratory illness in pregnant women and their infants. Am J Perinatol, 21: 333–339.

    Article  PubMed  Google Scholar 

  • Bland PB (1919). Influenza in its relation to pregnancy and labor. Am J Obstet Dis Women Child, 79: 184–197.

    Google Scholar 

  • Brown A (2006). Prenatal infection as a risk factor for schizophrenia. Schizophr Bull, 32: 200–202.

    Article  PubMed  Google Scholar 

  • Busby A, Dolk H, Armstrong B (2005). Eye anomalies. Seasonal variation and maternal viral infections. Epidemiology, 16: 317–322.

    Article  PubMed  Google Scholar 

  • Centers for Disease Control and Prevention (2007a). Prevention and control of influenza: recommendations of the advisory committee on immunization practices. MMWR, 56 (RR-6): 1–25.

    Google Scholar 

  • Centers for Disease Control and Prevention (2007b). Guidance for prevention and control of influenza in the peri- and postpartum settings. www.cdc.gov/flu/professionals/infectioncontrol/peri-post-settings.htm.

  • Cox S, Posner SS., McPheeters M, Jamieson DJ, Kourtis AP, Meikle S (2006). Hospitalizations with respiratory illness among pregnant women during influenza season. Obstet Gynecol, 107: 1315–1322.

    Article  PubMed  Google Scholar 

  • Cox S, Posner SF, McPheeters M, Jamieson DJ, Kourtis AP, Meikle S (2006). Influenza and pregnant women: hospitalization burden, 1998–2002. J Womens Health, 15: 891–893.

    Article  Google Scholar 

  • Czeizel AE, Puho EH, Acs N, Banhidy F (2007). High fever-related maternal diseases as possible causes of multiple congenital abnormalities: a population-based case-control study. Birth Defects Res A Clin Mol Teratol, 79: 544–551.

    Article  PubMed  CAS  Google Scholar 

  • Davis D, O’Brien MAT, Wolf FM, Freemantle N, Mazmanian P, Taylor-Vaisey A (1999). Impact of formal continuing medical education. Do conferences, workshops, rounds and other traditional continuing education activities change physician behaviour or health care outcomes? JAMA, 282: 867–874.

    Article  PubMed  CAS  Google Scholar 

  • Department of Health, United Kingdom (2006). Immunization against infectious disease- the Green Book. Chapter 19. Influenza, ed. R.M. Salisbury D, Noakes K. 2006, London, UK: TSO (The Stationery Office) www.dh.gov.uk/en/Policyandguidance/Healthandsocialcaretopics/Greenbook/index.htm.

  • Dodds L, McNeil SA, Fell DB, Allen VM, Coombs A, Scott J, MacDonald N (2007). Impact of influenza exposure on rates of hospital admissions and physician visits because of respiratory illness among pregnant women. CMAJ, 176: 463–468.

    Article  PubMed  Google Scholar 

  • Edwards MJ (2006). Review: hyperthermia and fever during pregnancy. Birth Defects Res A Clin Mol Teratol, 76: 507–516.

    Article  PubMed  CAS  Google Scholar 

  • Englund J (2003). Maternal immunization with inactivated influenza vaccine: rationale and experience. Vaccine, 21: 3460–3464.

    Article  PubMed  CAS  Google Scholar 

  • Englund JA, Mbawuike IN, Hammill H, Holleman MC, Baxter BD, Glezen WP (1993). Maternal immunization with influenza or tetanus toxoid vaccine for passive antibody protection in young infants. J Infect Dis, 168: 647–656.

    Article  PubMed  CAS  Google Scholar 

  • Erickson LJ, De Wals P., Farand L (2005). An analytical framework for immunization programs in Canada. Vaccine, 23: 2470–2476.

    Article  PubMed  CAS  Google Scholar 

  • Fatemi SH, Pearce DA, Brooks AI, Sidwell RW (2005). Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: a potential animal model for schizophrenia and autism. Synapse, 57: 91–99.

    Article  PubMed  CAS  Google Scholar 

  • France EK, Smith-Ray R, McClure D, Hambidge S, Xu S, Yamasaki K, Shay D, Weintraub E, Fry AM, Black SB, Shinefeld HR, Mullooly JP, Jackson LA, and the Vaccine Safety Datalink Team (2006). Impact of maternal influenza vaccination during pregnancy on the incidence of acute respiratory illness visits among infants. Arch Pediatr Adolesc Med, 160: 1277–1283.

    Article  PubMed  Google Scholar 

  • Freeman DW, Barno A (1959). Deaths from Asian Influenza Associated with Pregnancy. Amer J Obst Gynec, 78: 1172–1175.

    CAS  Google Scholar 

  • Glezen WP, Couch RB (1978). Interpandemic influenza in the Houston area, 1974–1976. N Engl J Med, 298: 587–592.

    Article  PubMed  CAS  Google Scholar 

  • Glezen WP, Keitel WA, Taber LH, Piedra PA, Clover RD, Couch RB (1919). Age distribution of patients with medically-attended illnesses caused by sequential variants of influenza A/H1N1: comparison to age-specific infection rates, 1978–1989. Am J Epidemiol, 133 (3): 296–304.

    Google Scholar 

  • Greenberg M, Jacobziner H, Pakter J, Weisl BA(1958). Maternal mortality in the epidemic of Asian influenza, New York City 1957. Amer J Obst and Gynec, 76: 897–902.

    CAS  Google Scholar 

  • Grimshaw JM, Thomas RE, MacLennan G, Fraser C, Ramsay CR, Vale L, Whitty P, Eccles MP, Matowe L, Shirran L, Wensing M, Dijkstra R, Donaldson C (2004). Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technol Assess, 8 (6): iii–iv, 1–72.

    PubMed  CAS  Google Scholar 

  • Halperin BA, MacKinnon-Cameron D, McNeil S (2006). Survey of knowledge, attitudes, and behaviour regarding influenza vaccination in pregnancy and childhood. International Conference on Women and Infectious Diseases (ICWID). Atlanta, USA March 17–19, 2006 (Abstract #38). www.womenshealthconf.org

  • Harris JW (1919). Influenza occurring in pregnant women. A statistical study of thirteen hundred and fifty cases. Jour A.M.A, 72: 978–980.

    Article  Google Scholar 

  • Hartert TV, Neuzil KM, Shintani AK, Mitchel EF Jr., Snowden MS, Wood LB, Dittus RS, Griffin MR (2003). Maternal morbidity and perinatal outcomes among pregnant women with respiratory hospitalizations for influenza season. Am J Obstet Gynecol, 189: 1705–1712.

    Article  PubMed  Google Scholar 

  • Heinonen OP, Shapiro S, Monson RR, Hartz SC, Rosenberg L, Slone D (1973). Immunization during pregnancy against poliomyelitis and influenza in relation to childhood malignancy. Int J Epidemiol, 2: 229–235.

    Article  PubMed  CAS  Google Scholar 

  • Irving WL, James DK, Stephenson T, Laing P, Jameson C, Oxford JS, Chakraverty P, Brown DWG, Boon ACM, Zambon MC (2000). Influenza virus infection in the second and third trimesters of pregnancy: a clinical and seroepidemiological study. BJOG, 107: 1282–1289.

    Article  PubMed  CAS  Google Scholar 

  • Izurieta HS, Thompson WW, Kramarz P, Shay DK, Davis RL, DeStefano F, Black S, Shinefield H, Fukuda K (2000). Influenza and the rates of hospitalization for respiratory disease among infants and young children. N Engl J Med, 342: 232–239.

    Article  PubMed  CAS  Google Scholar 

  • Kilbourne E (2006). Influenza pandemics of the 20th century. Emerg Iinfect Dis, 12: 9–14.

    Article  Google Scholar 

  • Kort BA, Cefalo RC, Baker VV(1986). Fatal influenza in pregnancy. Am J Perinatol, 2: 179–182.

    Article  Google Scholar 

  • Kwan ML, Metayer C, Crouse V, Buffler PA (2007). Maternal illness and drug/medication use during the period surrounding pregnancy and risk of childhood leukemia among offspring. Am J Epidemiol, 165: 27–35.

    Article  PubMed  Google Scholar 

  • Kwong JC, Sambell C, Johansen H, Stukel TA, Manuel DG (2006). The effect of universal influenza immunization on vaccination rates in Ontario. Health Rep, 17: 31–40.

    PubMed  Google Scholar 

  • Laibl VR, Sheffield JS (2005). Influenza and pneumonia in pregnancy. Clin Perinatol, 32: 727–738.

    Article  PubMed  Google Scholar 

  • Leck I (1971). Further tests of the hypothesis that influenza in pregnancy causes malformations. HSMHA Health Rep, 86: 265–269.

    Article  PubMed  CAS  Google Scholar 

  • Li Z, Ren A, Liu J, Pei L, Zhang L, Guo Z, Li Z (2007). Maternal flu or fever, medication use and neural tube defects: a population based case control study in northern China. Birth Defects Res A Clin Mol Teratol, 79: 295–300.

    Article  PubMed  CAS  Google Scholar 

  • Local Government Board (1919). 48th Annual Report 1918–1919. Supplement containing the report of the medical department. Section 2. Influenza. London: Her Majesty’s Stationery Office; 7–32.

    Google Scholar 

  • Lynberg MC, Muin JK, Lu X, Cocian T (1994). Maternal flu, fever and the risk of neural tube defects: a population-based case control study. Am J Epidemiol, 140: 244–255.

    PubMed  CAS  Google Scholar 

  • MacDonald NE, McNeil S, Allen VM, Scott J, Dodds L (2004). Influenza vaccine programs and pregnancy: a need for more evidence. J Obstet Gynaecol Can, 26: 961–963.

    PubMed  Google Scholar 

  • Mazmanian PE, Davis DA (2002). Continuing medical education and the physician as learner: guide to the evidence. JAMA, 288: 1057–1060.

    Article  PubMed  Google Scholar 

  • McGregor JA, Burns JC, Levin MJ, Burlington B, Meiklejohn G (1984). Transplacental passage of influenza A/Bangkok (H3N2) mimicking amniotic fluid infection syndrome. Am J Obstet Gynecol, 149: 856–859.

    PubMed  CAS  Google Scholar 

  • McKinney WP, Volkert P, Kaufman J (1990). Fatal swine influenza pneumonia during late pregnancy. Arch Intern Med, 150: 213–215.

    Article  PubMed  CAS  Google Scholar 

  • McNeil S, Dodds L, Fell D, Coombs A, Scott J, Allen V, Halperin B, MacDonald N (2006). Impact of influenza on respiratory-related hospitalizations and pre-term births in pregnant women: from evidence to public health practice in Canada, 83rd Canadian Pediatric Society Annual Meeting, June 13–17, 2006, St. John’s, NL Paediatr Child Health, 11 Suppl B: Abstract# 19B.

    Google Scholar 

  • McNeil SA, Dodds L, Allen VM, Scott J, Halperin B, MacDonald N (2007). Influenza vaccine programs and pregnancy: new Canadian evidence for immunization. JOGC, 29: 674–676.

    PubMed  Google Scholar 

  • Meyer U, Schwendener S, Feldon J, Yee B (2006). Prenatal and postnatal maternal contributions in the infection model of schizophrenia. Exp Brain Res 173: 243–257.

    Article  PubMed  Google Scholar 

  • Mortimer P (2006). Influenza-related death rates for pregnant women. Emerging infectious diseases. Emerg Infect Dis, 12: 1805–1806.

    Article  PubMed  Google Scholar 

  • Muennig PA, Khan K (2001). Cost-effectiveness of vaccination versus treatment of influenza in healthy adolescents and adults. CID, 33: 1879–1885.

    Article  CAS  Google Scholar 

  • Mullooly JP, Barker W, Nolan TF (1986). Risk of acute respiratory disease among pregnant women during influenza A epidemics. Public Health Rep, 101: 205–211.

    PubMed  CAS  Google Scholar 

  • Mullooly JP, Bridges CB, Thompson WW, Chen J, Weintaub E, Jackson LA, Black S, Shay DK, Vaccine Data Safety Adult Working Group (2007). Influenza- and RSV-associated hospitalizations among adults. Vaccine, 25: 846–855.

    Article  PubMed  Google Scholar 

  • Munoz FM, Greisinger AJ, Wehmanen OA, Mouzoon ME, Hoyle JC, Smith FA, Glezen WP (2005). Safety of influenza vaccination during pregnancy. Am J Obstet Gynecol, 192: 1098–1106.

    Article  PubMed  Google Scholar 

  • Murray DL, Imagawa DT, Okada DM, St. Geme JW Jr. (1979). Antibody response to monovalent A/New Jersey/8/76 influenza vaccine in pregnant women. J Clin Microbiol, 10: 184–187.

    PubMed  CAS  Google Scholar 

  • Naleway AL, Smith WJ, Mullooly JP (2006). Delivering influenza vaccine to pregnant women. Epidemiol Rev, 28: 47–53.

    Article  PubMed  Google Scholar 

  • National Advisory Committee on Immunization (2004), Statement on influenza vaccination for the 2004–2005 season. CCDR,30 (ACS-3): 1–32.

    Google Scholar 

  • National Advisory Committee on Immunization (2007). Statement on influenza vaccination for the 2007–2008 season. CCDR, 33 (ACS-7): 1–38.

    Google Scholar 

  • Neuzil KM, Reed GW, Mitchel EF, Simonsen L, Griffin MR (1998). Impact of influenza on cardiopulmonary hospitalizations in pregnant women. Am J Epidemiol, 148: 1094–1102.

    PubMed  CAS  Google Scholar 

  • Neuzil KM, Mellen BG, Wright PF, Mitchel EF Jr, Griffin MR (2000). The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics. N Engl Med, 324: 225–231.

    Article  Google Scholar 

  • Poland GA, Jacobson RM, Targonski PV (2007). Avian and pandemic influenza: an overview. Vaccine, 25: 3057–3061.

    Article  PubMed  CAS  Google Scholar 

  • Pool V, Iskander J (2006). Safety of influenza vaccination during pregnancy. Am J Obstet Gynec, 194: 1200–1201.

    Article  PubMed  Google Scholar 

  • Previc FH (2007). Prenatal influences on brain dopamine and their relevance to the rising incidence of autism. Med Hypotheses, 68: 46–60.

    Article  PubMed  CAS  Google Scholar 

  • Ramphal R, Donnelly WH, Small PA Jr (1980). Fatal influenzal pneumonia in pregnancy: failure to demonstrate transplacental transmission of influenza virus. Am J Obstet Gynecol, 138: 347–348.

    PubMed  CAS  Google Scholar 

  • Rastogi D, Wang C., Mao X, Lendor C, Rothman PB, Miller RL (2007). Antigen-specific immune responses to influenza vaccine in utero. J Clin Invest, 117: 1637–1646.

    Article  PubMed  CAS  Google Scholar 

  • Registrar General’s Report 1918/1919 (1919). Eighty-second annual report of the registrar-general of births, deaths, and marriages in England and Wales (1919). Her Majesty's Stationery Office. p. xxviii.

    Google Scholar 

  • Roberts S, Hollier LM, Sheffield J, Laibl V, Wendel GD Jr (2006). Cost-effectiveness of universal influenza vaccination in a pregnant population. Obstet Gynecol, 107: 1323–1329.

    Article  PubMed  Google Scholar 

  • Saxen L, Holmberg PC, Kurpa K, Kuosma E, Pyhala R (1990). Influenza epidemics and anencephaly. AJPH 80: 473–475.

    Article  CAS  Google Scholar 

  • Schanzer DL, Langley JM, Tam TWS (2007). Influenza-attributed hospitalization rates among pregnant women in Canada 1994–2000. JOGC, 29: 622–629.

    PubMed  Google Scholar 

  • Schoenbaum SC, Weinstein L (1979). Respiratory infection in pregnancy. Clin Obstet Gynecol, 22: 293–300.

    Article  PubMed  CAS  Google Scholar 

  • Shu Y, Yu H, Li D (2006). Lethal avian influenza A (H5N1) infection in a pregnant woman in Anhui Province, China. N Engl J Med, 354: 1421–1422.

    Article  PubMed  CAS  Google Scholar 

  • Silverman NS, Greif A (2001). Influenza vaccination during pregnancy: patients’ and physicians’ attitudes. J Reprod Med, 46: 989–994.

    PubMed  CAS  Google Scholar 

  • Simonsen L, Fukuda K, Schonberger LB, Cox NJ (2000). The impact of influenza epidemics on hospitalizations. J Infect Dis, 181: 831–837.

    Article  PubMed  CAS  Google Scholar 

  • Simonsen L, Reichert TA, Viboud C, Blackwelder WC, Taylor RJ, Miller MA (2005). Impact of influenza vaccination on seasonal mortality in the US elderly population. Arch Intern Med, 165: 265–272.

    Article  PubMed  Google Scholar 

  • Stanwell-Smith R, Parker AM, Chakraverty P, Soltanpoor N, Simpson CN (1994). Possible association of influenza A with fetal loss: investigation of a cluster of spontaneous abortions and stillbirths. Commun Dis Rep CDR Review, 4: R28–R32.

    CAS  Google Scholar 

  • Steinhoff MC, Zaman K, Roy E, Arifeen SE, Rahman M, Raqib R, Shahid N (2006). Incidence of vaccine preventable influenza illness in 0–5 month-old infants. Infectious Disease Society of America. Toronto Canada. October 2006: Abstract LB-6.

    Google Scholar 

  • Sumaya CV, Gibbs RS (1979). Immunization of pregnant women with influenza A/New Jersey/76 virus vaccine: reactogenicity and immunogenicity. J Infect Dis, 140: 141–146.

    Article  PubMed  CAS  Google Scholar 

  • Taubenberger JK, Morens DM (2006). 1918 Influenza: the mother of all pandemics. Emerg Infect Dis, 12: 15–22.

    Article  PubMed  Google Scholar 

  • Tuyishime J-de-D, DeWals P, Moutquin J-M, Frost E (2003). Influenza-like illness during pregnancy: results from a study in the Eastern Townships, Province of Quebec. JOGC, 25: 1020–1025.

    PubMed  Google Scholar 

  • Viboud C, Tam T, Fleming D, Miller MA, Simonsen L (2006). 1951 influenza epidemic, England and Wales, Canada, and the United States. Emerg Infect Dis, 12: 661–668.

    Article  PubMed  Google Scholar 

  • Voldsgaard P, Schiffman J, Mednick S, Rodgers B, Christensen H, Bredkjaer S, Schulsinger F (2002). Accuracy of retrospective reports of infections during pregnancy. Int J Methods Psychiatr Res, 11: 184–186.

    Article  PubMed  Google Scholar 

  • Wallis DH, Chin JL, Sur DKC (2004). Influenza vaccination in pregnancy: current practices in a suburban community. J Am Board Fam Pract, 17: 287–291.

    Article  PubMed  Google Scholar 

  • Widelock D, Csizmas L, Klein S (1963). Influenza, pregnancy and fetal outcome. Public Health Rep, 78 (1): 1–11.

    PubMed  CAS  Google Scholar 

  • Wong CM, Yang L, Chan KP, Leung GM, Chan KH, Guan Y, Lam TH, Hedley AJ, Peiris JSM (2006). Influenza-associated hospitalization in a subtropical city. PLOS Medicine, 3: 485–492.

    Article  Google Scholar 

  • World Health Organization (2007). Cumulative number of confirmed human cases of Avian Influenza A/(H5N1) Reported to WHO: July 11, 2007. www.who.int/csr/disease/avian_influenza/country/cases_table_2007_07_11/en/index.html.

  • Yawn DH, Pyeatte JC, Joseph JM, Eichler SL, Garcia-Bunuel R (1971). Transplacental transfer of influenza virus. JAMA, 216: 1022–1023.

    Article  PubMed  CAS  Google Scholar 

  • Yeager DP, Toy EC, Baker B III (1999). Influenza vaccination in pregnancy. Am J Perinatol, 16: 283–286.

    Article  PubMed  CAS  Google Scholar 

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McNeil, S., Halperin, B., MacDonald, N. (2009). Influenza in Pregnancy: The Case for Prevention. In: Finn, A., Curtis, N., Pollard, A. (eds) Hot Topics in Infection and Immunity in Children V. Advances in Experimental Medicine and Biology, vol 634. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79838-7_15

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