Challenges in the Evaluation and Management of Bone and Joint Infections and the Role of New Antibiotics for Gram Positive Infections

  • Sheldon L. Kaplan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 634)


Osteomyelitis and septic arthritis are two of the more common invasive bacterial infections in children (Krogstad, 2004). Changes in the epidemiology of these infections, mostly related to the emergence of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) as well advances in molecular microbiology and imaging techniques have led to modifications in the approach to the diagnosis and management of children with osteomyelitis and/or septic arthritis, which will be reviewed in this chapter.

Site of Acute Hematogenous Osteomyelitis in Children

The majority of osteomyelitis cases in children arise hematogenously and typically occur in the metaphysis of long bones such as the femur, tibia, and humerus, which together account for about two-thirds of cases (Krogstad, 2004). Vertebral and pelvic locations are noted in about 2 % and 8% of cases, respectively.


Staphylococcus aureusis by far the most common bacterial pathogen causing osteomyelitis in...


Optic Neuritis Septic Arthritis Chronic Osteomyelitis Vertebral Osteomyelitis Aureus Isolate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of PediatricsBaylor College of Medicine, Chief, Infectious Disease Service, Texas Children’s Hospital, Feigin Center MC 3-2371HoustonUSA

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