Calcium ion signaling in astrocytes

  • Joachim W. Deitmer
  • Karthika Singaravelu
  • Christian Lohr

8.1 Introduction

Ca2+signaling has been recognized as one of the major second messenger steps in most cell types, including astrocytes, the major macroglial cell type in vertebrate nervous systems. Astrocytes are by no means a homogeneous group of glial cells, but comprise a number of different cell types (see Chap. 1). However, in contrast to a decade ago, when mammalian astrocytes were divided into either protoplasmic type 1 or fibrous type II astrocytes, we assume today that there are many types of astrocytes in different brain regions. Another classification has recognized astrocytes with a dense distribution of glutamate uptake transporters (EAAT, excitatory amino acid transporter) and poor equipment of ionotropic glutamate receptors, while another type of astrocytes shows a poor expression of EAATs, but prominent distribution of ionotropic glutamate receptors. As with all of these cell type classifications established so far, there are known exemptions, such as the Bergmann...


Glial Cell Ionotropic Glutamate Receptor Metabotropic Receptor Store Depletion CRAC Channel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



2-Aminoethoxydiphenyl borate


Adenosine diphosphate


Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid


Adenosine 5¢-triphosphate


1,2-bis(o-aminophenoxy)ethane-N,N,N¢,N¢-tetraacetic acid


Ca2+ influx factor


Ca2+ release-activated channel






Excitatory amino acid transporter


Endoplasmic reticulum


Gamma-aminobutyric acid




Ca2+-independent phopholipase A2




Ionotropic purinoceptor


Metabotropic purinoceptor


Phospholipase C


Sarcoplasmic-endoplasmic reticulum Ca2+-ATPase


Soluble N-ethyl maleimide-sensitive fusion protein attachment protein receptor


Store-operated Ca2+ entry


Stromal interaction molecule 1


Vesicular glutamate transporter



Our studies on this topic have been supported by grants from the Deutsche Forschungsgemeinschaft (SFB 530, GRK 845), which we gratefully acknowledge.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Joachim W. Deitmer
    • 1
  • Karthika Singaravelu
    • 1
  • Christian Lohr
  1. 1.Abteilung für Allgemeine ZoologieFB Biologie, TU KaiserslauternGermany

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