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Alexander Disease: A Genetic Disorder of Astrocytes

Keywords

  • Glial Fibrillary Acidic Protein
  • Intermediate Filament
  • Glial Fibrillary Acidic Protein Expression
  • Glial Fibrillary Acidic Protein Level
  • Alexander Disease

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Fig. 24.1
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Abbreviations

CNS:

Central nervous system

CSF:

Cerebrospinal fluid

EM:

Electron microscopy

GABA:

γ-Amino butyric acid

GAD:

Glutamic acid decarboxylase

GFAP:

Glial fibrillary acidic protein

GFP:

Green fluorescent protein

Glt-1:

Glial l-glutamate transporter

hGFAP:

Human GFAP

JNK:

c-Jun amino-terminal kinase

MIM:

Mendelian inheritance in man

MRI:

Magnetic resonance imaging

SDS-PAGE:

Sodium dodecyl sulfate polyacrylamide gel electrophoresis

TNFα:

Tumor necrosis factor α

TRH:

Thyrotropin releasing hormone

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Acknowledgments

We thank Daniel M. Bolt for statistical assistance, Marjo van der Knaap for permission to use Fig. 24.1, Anne B. Johnson for permission to use Fig. 24.2, and Rong Li for the images in Fig. 24.7. The authors would also like to thank the editors for giving them the opportunity to write this extensive, and final, review of their careers. One more would be too many. This work was supported by NINDS grant P01NS42803.

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Brenner, M., Goldman, J.E., Quinlan, R.A., Messing, A. (2009). Alexander Disease: A Genetic Disorder of Astrocytes. In: Haydon, P., Parpura, V. (eds) Astrocytes in (Patho)Physiology of the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-79492-1_24

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