The Impact of Astrocyte Mitochondrial Metabolism on Neuroprotection During Aging

  • Lora T. Watts
  • James D. Lechleiter

23.1 Introduction

Accumulation of oxidative damage as the result of normal mitochondrial metabolism is widely considered to be a fundamental cause of aging. A central tenet of this theory is that mitochondria themselves become dysfunctional. In the central nervous system (CNS), the focus of research on aging has primarily revolved around changes in and effects of neuronal mitochondrial metabolism. However, there is increasing interest in the role that astrocyte mitochondria play in the aging process. Little is known about the cumulative effects of aging on astrocyte mitochondria or on energy-dependent processes within astrocytes. It is likely that diminished astrocyte function throughout the aging process is a prominent determinant of both neuronal survival as well as survival of the entire organism. In this chapter, we focus our discussion on the impact of astrocyte mitochondrial metabolism during the aging process. We present a brief review of astrocyte bioenergetics followed by a...


Purinergic Receptor Mitochondrial Metabolism Astrocyte Culture Mitochondrial Energy Production TMRE Fluorescence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



1-Aminocyclopentane-1,3-dicarboxylic acid


2-Methylthio adenosine 5-diphosphate


Mitochondrial membrane potential


γ-Glutamyl cysteine


Adenosine triphosphate


Modulatory subunit of GCL


Central nervous system




Deoxyribonucleic acid


Endoplasmic reticulum


Lowest value of fluorescence in the cytosol


Peak fluorescent intensity observed in single mitochondrial


Glutamate cysteine ligase


Catalytic subunit of GCL


Glial fibrillary acidic protein


Glutathione peroxidase


Glutathione synthetase




Inositol 1,4,5 trisphosphate


Membrane permeant butyryloxymethyl ester of IP3


IP3 receptor


Metabotropic glutamate receptor


Multidrug resistance protein type 1


N-methyl-d-aspartic acid


Nuclear magnetic resonance


Pheochromocytoma PC12 cell


Phospholipase C beta


Ruthenium 360


Sarco-endoplasmic reticulum Ca2+-ATPase


tert-Butyl hydrogen peroxide


Tricarboxylic acid


Tetramethyl rhodamine ethyl ester


Xestospongin C


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Cellular and Structural BiologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA

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