Connexins and pannexins: Two gap junction families mediating glioma growth control

  • Charles P.K. Lai
  • Christian C. Naus

22.1 Introduction

Astrocytes are the most common glial cells found in the central nervous system (CNS). They are known to provide neurons with structural support and neurotrophic substances, as well as buffer the extracellular milieu and contribute to the blood–brain barrier (reviewed in Hatten et al., 1991). Unlike neurons, astrocytes can be readily induced to divide, and this may contribute to the formation of gliomas, which accounts for more than 65% of all primary brain tumors (Muller et al., 1977). However, since gliomas arise in the brain, therapeutic strategies including radiotherapy, chemotherapy, and complete surgical removal are often difficult to implement and pose a high risk of side effects to patients (Butowski et al., 2006). Moreover, invasive gliomas frequently relapse after treatments due to their extensive infiltration into surrounding tissues, consequently resulting in death in nearly all cases (Reardon et al., 2006). Therefore, exploring a more effective treatment...


Cx43 Expression Herpes Simplex Virus Thymidine Kinase Flufenamic Acid Intercellular Channel Bystander Killing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





Cyclin-dependant kinase


Central nervous system


Ciliary neurotrophic factor


CNTF receptor




Insulin-like growth factor 1




Janus tyrosine kinase/signal transducer and activator of transcription


Monocyte chemotactic protein 1


Milk fat globule epidermal growth factor 8






Ribosomal protein L19


Zonula occludens 1



Supported by funds from the Canadian Institutes of Health Research. Christian C. Naus is a recipient of a Canada Research Chair. The authors thank Dr. D.C. Spray for his thoughtful review.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Charles P.K. Lai
    • 1
  • Christian C. Naus
    • 1
  1. 1.Department of Cellular and Physiological SciencesThe Faculty of Medicine, The University of British ColumbiaVancouverCanada

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