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Astrocytes in (Patho)Physiology of the Nervous System pp 513–525Cite as

Physiological and Pathological Roles of Astrocyte-mediated Neuronal Synchrony

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Abbreviations

AMPA:

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

ATP:

Adenosine 5’-triphosphate

D-AP5:

D-2-Amino-5-phosphonopentanoic acid

GABA:

Gamma-aminobutyric acid

NMDA:

N-Methyl-D-aspartate

NMDAR:

NMDA receptor

PDS:

Paroxysmal depolarizing shift

SIC:

Slow inward current

TTX:

Tetrodotoxin

References

  • Alonso A, Llinas RR (1989) Subthreshold Na+-dependent theta-like rhythmicity in stellate cells of entorhinal cortex layer II. Nature 342:175–177

    Article  PubMed  CAS  Google Scholar 

  • Amitai Y (1994) Membrane potential oscillations underlying firing patterns in neocortical neurons. Neuroscience 63:151–161

    Article  PubMed  CAS  Google Scholar 

  • Angulo MC, Kozlov AS, Charpak S, Audinat E (2004) Glutamate released from glial cells synchronizes neuronal activity in the hippocampus. J Neurosci 24:6920–6927

    Article  PubMed  CAS  Google Scholar 

  • Bacci A, Huguenard JR (2006) Enhancement of spike-timing precision by autaptic transmission in neocortical inhibitory interneurons. Neuron 49:119–130

    Article  PubMed  CAS  Google Scholar 

  • Borst JG, Sakmann B (1999) Depletion of calcium in the synaptic cleft of a calyx-type synapse in the rat brainstem. J Physiol 521:123–133

    Article  PubMed  CAS  Google Scholar 

  • Bouskila Y, Dudek FE (1993) Neuronal synchronization without calcium-dependent synaptic transmission in the hypothalamus. Proc Natl Acad Sci USA 90:3207–3210

    Article  PubMed  CAS  Google Scholar 

  • Bushong EA, Martone ME, Jones YZ, Ellisman MH (2002) Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains. J Neurosci 22:183–192

    PubMed  CAS  Google Scholar 

  • Cobb SR, Buhl EH, Halasy K, Paulsen O, Somogyi P (1995) Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons. Nature 378:75–78

    Article  PubMed  CAS  Google Scholar 

  • Congar P, Leinekugel X, Ben-Ari Y, Crépel V (1997) A long-lasting calcium-activated nonselective cationic current is generated by synaptic stimulation or exogenous activation of group I metabotropic glutamate receptors in CA1 pyramidal neurons. J Neurosci 17:5366–5379

    PubMed  CAS  Google Scholar 

  • Crépel V, Aniksztejn L, Ben-Ari Y, Hammond C (1994) Glutamate metabotropic receptors increase a Ca2+. -activated nonspecific cationic current in CA1 hippocampal neurons J Neurophysiol 72:1561–1569

    PubMed  Google Scholar 

  • D’Ascenzo M, Fellin T, Terunuma M, Revilla-Sanchez R, Meaney DF, Auberson YP, Moss SJ, Haydon PG (2007) mGluR5 stimulates gliotransmission in the nucleus accumbens. Proc Natl Acad Sci USA 104:1995–2000

    Article  PubMed  Google Scholar 

  • Desmaisons D, Vincent JD, Lledo PM (1999) Control of action potential timing by intrinsic subthreshold oscillations in olfactory bulb output neurons. J Neurosci 19:10727–10737

    PubMed  CAS  Google Scholar 

  • Duan S, Anderson CM, Keung EC, Chen Y, Swanson RA (2003) P2X7 receptor-mediated release of excitatory amino acids from astrocytes. J Neurosci 23:1320–1328

    PubMed  CAS  Google Scholar 

  • Dudek FE, Yasumura T, Rash JE (1998) ‘Non-synaptic’ mechanisms in seizures and epileptogenesis. Cell Biol Int 22:793–805

    Article  PubMed  CAS  Google Scholar 

  • Faber DS, Korn H (1989) Electrical field effects: Their relevance in central neural networks. Physiol Rev 69:821–863

    PubMed  CAS  Google Scholar 

  • Fellin T, Pascual O, Gobbo S, Pozzan T, Haydon PG, Carmignoto G (2004) Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron 43:729–743

    Article  PubMed  CAS  Google Scholar 

  • Fellin T, Pozzan T, Carmignoto G (2006a) Purinergic receptors mediate two distinct glutamate release pathways in hippocampal astrocytes. J Biol Chem 281:4274–4284

    Article  CAS  Google Scholar 

  • Fellin T, Gomez-Gonzalo M, Gobbo S, Carmignoto G, Haydon PG (2006b) Astrocytic glutamate is not necessary for the generation of epileptiform neuronal activity in hippocampal slices. J Neurosci 26:9312–9322

    Article  CAS  Google Scholar 

  • Garaschuk O, Milos RI, Konnerth A (2006) Targeted bulk-loading of fluorescent indicators for two-photon brain imaging in vivo. Nat Protoc 1:380–386

    Article  PubMed  CAS  Google Scholar 

  • Ghai RS, Bikson M, Durand DM (2000) Effects of applied electric fields on low-calcium epileptiform activity in the CA1 region of rat hippocampal slices. J Neurophysiol 84:274–280

    PubMed  CAS  Google Scholar 

  • Gobel W, Kampa BM, Helmchen F (2007) Imaging cellular network dynamics in three dimensions using fast 3D laser scanning. Nat Methods 4:73–79

    Article  PubMed  Google Scholar 

  • Grosche J, Matyash V, Moller T, Verkhratsky A, Reichenbach A, Kettenmann H (1999) Microdomains for neuron–glia interaction: Parallel fiber signaling to Bergmann glial cells. Nat Neurosci 2:139–143

    Article  PubMed  CAS  Google Scholar 

  • Gutfreund Y, yarom Y, Segev I (1995) Subthreshold oscillations and resonant frequency in guinea-pig cortical neurons: Physiology and modelling. J Physiol 483 (Pt 3):621–640

    PubMed  CAS  Google Scholar 

  • Haas HL, Jefferys JG (1984) Low-calcium field burst discharges of CA1 pyramidal neurones in rat hippocampal slices. J Physiol 354:185–201

    PubMed  CAS  Google Scholar 

  • Haydon PG, Carmignoto G (2006) Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 86:1009–1031

    Article  PubMed  CAS  Google Scholar 

  • Jefferys JGR (2003) Models and mechanisms of experimental epilepsies. Epilepsia 44(Suppl 12):44–50

    Article  Google Scholar 

  • Jefferys JG, Haas HL (1982) Synchronized bursting of CA1 hippocampal pyramidal cells in the absence of synaptic transmission. Nature 300:448–450

    Article  PubMed  CAS  Google Scholar 

  • Konnerth A, Heinemann U, Yaari Y (1984) Slow transmission of neural activity in hippocampal area CA1 in absence of active chemical synapses. Nature 307:69–71

    Article  PubMed  CAS  Google Scholar 

  • Konnerth A, Heinemann U, Yaari Y (1986) Nonsynaptic epileptogenesis in the mammalian hippocampus in vitro. I. Development of seizurelike activity in low extracellular calcium. J Neurophysiol 56:409–423

    PubMed  CAS  Google Scholar 

  • Kozlov AS, Angulo MC, Audinat E, Charpak S (2006) Target cell-specific modulation of neuronal activity by astrocytes. Proc Natl Acad Sci USA 103:10058–10063

    Article  PubMed  CAS  Google Scholar 

  • Laubach M, Wessberg J, Nicolelis MA (2000) Cortical ensemble activity increasingly predicts behaviour outcomes during learning of a motor task. Nature 405:567–571

    Article  PubMed  CAS  Google Scholar 

  • MacVicar BA, Dudek FE (1981) Electrotonic coupling between pyramidal cells: A direct demonstration in rat hippocampal slices. Science 213:782–785

    Article  PubMed  CAS  Google Scholar 

  • Miles R, Wong RK (1983) Single neurons can initiate synchronized population discharge in the hippocampus. Nature 306:371–373

    Article  PubMed  CAS  Google Scholar 

  • Mothet JP, Parent AT, Wolosker H, Brady RO, Jr., Linden DJ, Ferris CD, Rogawski MA, Snyder SH (2000) d-serine is an endogenous ligand for the glycine site of the N. -methyl-d- aspartate receptor Proc Natl Acad Sci USA 97:4926–4931

    Article  PubMed  CAS  Google Scholar 

  • Mothet JP, Pollegioni L, Ouanounou G, Martineau M, Fossier P, Baux G (2005) Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter d. -serine Proc Natl Acad Sci USA 102:5606–5611

    Article  PubMed  CAS  Google Scholar 

  • Nagayama S, Zeng S, Xiong W, Fletcher ML, Masurkar AV, Davis DJ, Pieribone VA, Chen WR (2007) In vivo simultaneous tracing and Ca2+. imaging of local neuronal circuits Neuron 53:789–803

    Article  PubMed  CAS  Google Scholar 

  • Nimmerjahn A, Kirchhoff F, Kerr JN, Helmchen F (2004) Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nat Methods 1:31–37

    Article  PubMed  CAS  Google Scholar 

  • Parri HR, Gould TM, Crunelli V (2001) Spontaneous astrocytic Ca2+. oscillations in situ drive NMDAR-mediated neuronal excitation Nat Neurosci 4:803–812

    Article  PubMed  CAS  Google Scholar 

  • Pascual O, Casper KB, Kubera C, Zhang J, Revilla-Sanchez R, Sul JY, Takano H, Moss SJ, McCarthy K, Haydon PG (2005) Astrocytic purinergic signaling coordinates synaptic networks. Science 310:113–116

    Article  PubMed  CAS  Google Scholar 

  • Pasti L, Volterra A, Pozzan T, Carmignoto G (1997) Intracellular calcium oscillations in astrocytes: A highly plastic, bidirectional form of communication between neurons and astrocytes in situ. J Neurosci 17:7817–7830

    PubMed  CAS  Google Scholar 

  • Perea G, Araque A (2005) Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes. J Neurosci 25:2192–2203

    Article  PubMed  CAS  Google Scholar 

  • Perez GJ, Bonev AD, Patlak JB, Nelson MT (1999) Functional coupling of ryanodine receptors to KCa channels in smooth muscle cells from rat cerebral arteries. J Gen Physiol 113:229–238

    Article  PubMed  CAS  Google Scholar 

  • Rusakov DA, Fine A (2003) Extracellular Ca2+. depletion contributes to fast activity-dependent modulation of synaptic transmission in the brain Neuron 37:287–297

    Article  PubMed  CAS  Google Scholar 

  • Schell MJ, Molliver ME, Snyder SH (1995) d-serine, an endogenous synaptic modulator: Localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci USA 92:3948–3952

    Article  PubMed  CAS  Google Scholar 

  • Schoppa NE (2006) Synchronization of olfactory bulb mitral cells by precisely timed inhibitory inputs. Neuron 49:271–283

    Article  PubMed  CAS  Google Scholar 

  • Silva LR, Amitai Y, Connors BW (1991) Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons. Science 251:432–435

    Article  PubMed  CAS  Google Scholar 

  • Singer W (1999) Neuronal synchrony: A versatile code for the definition of relations? Neuron 24:49–65

    Article  PubMed  CAS  Google Scholar 

  • Singer W, Gray CM (1995) Visual feature integration and the temporal correlation hypothesis. Annu Rev Neurosci 18:555–586

    Article  PubMed  CAS  Google Scholar 

  • Stanley EF (2000) Presynaptic calcium channels and the depletion of synaptic cleft calcium ions. J Neurophysiol 83:477–482

    PubMed  CAS  Google Scholar 

  • Stosiek C, Garaschuk O, Holthoff K, Konnerth A (2003) In vivo two-photon calcium imaging of neuronal networks. Proc Natl Acad Sci USA 100:7319–7324

    Article  PubMed  CAS  Google Scholar 

  • Taylor CP, Dudek FE (1982) Synchronous neural afterdischarges in rat hippocampal slices without active chemical synapses. Science 218:810–812

    Article  PubMed  CAS  Google Scholar 

  • Tian G-F, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Wang X, Zielke HR, Kang J, Nedergaard M (2005) An astrocytic basis of epilepsy. Nat Med 11:973–981

    PubMed  CAS  Google Scholar 

  • Wehr M, Laurent G (1996) Odour encoding by temporal sequences of firing in oscillating neural assemblies. Nature 384:162–166

    Article  PubMed  CAS  Google Scholar 

  • Whittington MA, Traub RD (2003) Interneuron diversity series: Inhibitory interneurons and network oscillations in vitro. Trends Neurosci 26:676–682

    Article  PubMed  CAS  Google Scholar 

  • Zanotti S, Charles A (1997) Extracellular calcium sensing by glial cells: Low extracellular calcium induces intracellular calcium release and intercellular signaling. J Neurochem 69:594–602

    Article  PubMed  CAS  Google Scholar 

  • Zhuo L, Theis M, Alvarez-Maya I, Brenner M, Willecke K, Messing A (2001) hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis 31:85–94

    Article  PubMed  CAS  Google Scholar 

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  1. Istituto CNR di Neuroscienze and Dipartimento di Scienze Biomediche Sperimentali, Università di Padova, Viale G, Colombo 3, 35121 Padova, Italy

    G Carmignoto

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  1. G Carmignoto
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  2. Micaela Zonta
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    Carmignoto, G., Zonta, M. (2009). Physiological and Pathological Roles of Astrocyte-mediated Neuronal Synchrony. In: Haydon, P., Parpura, V. (eds) Astrocytes in (Patho)Physiology of the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-79492-1_20

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