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The tripartite synapse

  • Michael M. Halassa
  • Philip G. Haydon
Chapter

The study of the astrocyte was hampered during the 1900s by the lack of experimental techniques to permit experimental stimulation and recording of the function of the astrocyte. Even in the early 1900s it was appreciated that electrical signals were the mechanism of conduction of neuronal signals (Adrian, 1912). Since astrocytes exhibit a large negative resting potential (Butt and Kalsi, 2006) their functional activity was mute to the electrophysiological techniques used to study nervous system function.

Despite the poor experimental tractability of astrocytes, several pioneering studies did, however, provide important insights into the functional roles for these glia in brain function. Microscopy, immunocytochemistry, and biochemistry were used to identify glycogen storage granules (Magistretti, 2006; Tsacopoulos and Magistretti, 1996), and the presence of glutamate transporters (Anderson and Swanson, 2000) in astrocytic membranes. These observations provided a basis for the...

Keywords

Synaptic Transmission P2Y1 Receptor Excitatory Synaptic Transmission Schaffer Collateral Astrocytic Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ATP

Adenosine 5′-triphosphate

NMDA

N-methyl-d-aspartate

SON

Supraoptic nucleus

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Michael M. Halassa
    • 1
  • Philip G. Haydon
    • 1
  1. 1.University of Pennsylvania School of MedicineDepartment of NeuroscienceUSA

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