Release of Trophic Factors and Immune Molecules from Astrocytes

  • Ying Y. Jean
  • Issa P. Bagayogo
  • Cheryl F. Dreyfus
It is now quite clear that as part of their support role, astrocytes produce and release multiple proteins that impact survival, migration, differentiation, and function of proximate neurons. This astrocyte role is particularly evident during development, remains in play in the normal adult brain, and is enhanced after injury. The molecules produced include those known traditionally as cytokines, chemokines, and trophic factors. Importantly, these proteins can serve as trophic or toxic agents and may be differentially regulated by the signals impacting on astrocytes at various stages of brain development and maturity (Fig. 13.1). The story of proteins produced by astrocytes, then, is a complex one. Multiple trophic or toxic molecules may be produced. The molecular mix may change from the developing animal to the adult, and after a lesion. Moreover, there is regional heterogeneity in the astrocyte-derived molecules, suggesting that those produced by region-specific astrocytes may be...


Nerve Growth Factor Glial Fibrillary Acidic Protein BDNF mRNA Cortical Astrocyte Immune Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Astrocyte-conditioned media


α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid


Brain-derived neurtrophic factor


Ciliary neurotrophic factor


Fibroblast growth factor


Glial cell line-derived growth factor


Glial fibrillary acidic protein




Insulin-like growth factor


Insulin-like growth factor binding protein






Long-term potentiation


Metabotropic glutamate receptor


Nerve growth factor




Transforming growth factor


Tumor necrosis factor




Vasoactive intestinal peptide



The work referred to in this review that was performed in the Dreyfus lab was supported by NIH HD23315.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ying Y. Jean
    • 1
  • Issa P. Bagayogo
  • Cheryl F. Dreyfus
    • 1
  1. 1.Department of Neuroscience and Cell BiologyUMDNJ-Robert Wood Medical School, PiscatawayNJUSA

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