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Synaptic Information Processing by Astrocytes

  • Gertrudis Perea
  • Alfonso Araque
Chapter

11.1 Introduction

Since the time of the initial studies of the nervous system, neurons were recognized as the cellular elements responsible for the information processing of the nervous system, while glial cells were considered as playing simple supportive roles to neurons. The fundamental attribute of neurons is their cellular electrical excitability, which is based on the expression of a plethora of ligand- and voltage-gated membrane channels that give rise to prominent membrane currents and membrane potential variations, which represent the biophysical substrate underlying the integration and transfer of information at the cellular level in the Central Nervous System (CNS). By contrast, glial cells are not electrically excitable. Although they are able to express some of the ion channels that are expressed by neurons, the level of expression of some key channels is not sufficiently high to support the generation of active electrical behaviors in response to different stimuli....

Keywords

Synaptic Activity Synaptic Terminal Schaffer Collateral Astrocytic Process Electrical Excitability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

Ach

Acetylcholine

AMPA

(RS)- IJ-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

ATP

Adenosine 5′-triphosphate

CNS

Central nervous system

GABA

γ-Aminobutyric acid

OPCs

Oligodendrocyte precursors cells

SC

Schaffer collaterals

Notes

Acknowledgments.

This chapter was written with grant support from the Ministerio de Educación y Ciencia, Spain (BFU2004-00448) to A.A.

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Gertrudis Perea
    • 1
  • Alfonso Araque
  1. 1.Instituto CajalCSICMadridSpain

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