• Christine M. Bucks
  • Peter D. Katsikis*
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 633)


Costimulatory Molecule Vesicular Stomatitis Virus CD28 Signaling Double Positive CD28 Costimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by NIH grants R01 AI66215, R01 AI46719, and R01 AI62437 from the National Institutes of Health awarded to PDK.


  1. 1.
    Bretscher, P. Cohn, M. (1970)A theory of self–nonself discrimination. Science 169, 1042–1049CrossRefGoogle Scholar
  2. 2.
    Lafferty, K.J. Cunningham, A.J. (1975)A new analysis of allogeneic interactions. Aust J Exp Biol Med Sci 53, 27–42CrossRefGoogle Scholar
  3. 3.
    Aruffo, A. Seed, B. (1987)Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system. Proc Natl Acad Sci USA 84, 8573–8577CrossRefGoogle Scholar
  4. 4.
    Gmunder, H. Lesslauer, W. (1984)A 45-kDa human T-cell membrane glycoprotein functions in the regulation of cell proliferative responses. Eur J Biochem 142, 153–160CrossRefGoogle Scholar
  5. 5.
    Ledbetter, J.A. et al. (1985)Antibodies to Tp67 and Tp44 augment and sustain proliferative responses of activated T cells. J Immunol 135, 2331–2336Google Scholar
  6. 6.
    Moretta, A., Pantaleo, G., Lopez-Botet, M. Moretta, L. (1985)Involvement of T44 molecules in an antigen-independent pathway of T cell activation. Analysis of the correlations to the T cell antigen–receptor complex. J Exp Med 162, 823–838CrossRefGoogle Scholar
  7. 7.
    Weiss, A., Manger, B. Imboden, J. (1986)Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells. J Immunol 137, 819–825Google Scholar
  8. 8.
    Martin, P.J. et al. (1986)A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J Immunol 136, 3282–3287Google Scholar
  9. 9.
    June, C.H., Ledbetter, J.A., Lindsten, T. Thompson, C.B. (1989)Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes. J Immunol 143, 153–161Google Scholar
  10. 10.
    Ledbetter, J.A. et al. (1990)CD28 ligation in T-cell activation: evidence for two signal transduction pathways. Blood 75, 1531–1539Google Scholar
  11. 11.
    Linsley, P.S. et al. (1992)Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med 176, 1595–1604CrossRefGoogle Scholar
  12. 12.
    Stamper, C.C. et al. (2001)Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses Nature 410, 608–611CrossRefGoogle Scholar
  13. 13.
    Martin, M., Schneider, H., Azouz, A. Rudd, C.E. (2001)Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function. J Exp Med 194, 1675–1681CrossRefGoogle Scholar
  14. 14.
    Walunas, T.L., Bakker, C.Y. Bluestone, J.A. (1996)CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med 183, 2541–2550CrossRefGoogle Scholar
  15. 15.
    Walunas, T.L. et al. (1994)CTLA-4 can function as a negative regulator of T cell activation. Immunity 1, 405–413CrossRefGoogle Scholar
  16. 16.
    Hutloff, A. et al. (1999)ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397, 263–266CrossRefGoogle Scholar
  17. 17.
    Dong, C. et al. (2001)ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409, 97–101CrossRefGoogle Scholar
  18. 18.
    Dong, C., Temann, U.A. Flavell, R.A. (2001)Cutting edge: critical role of inducible costimulator in germinal center reactions. J Immunol 166, 3659–3662Google Scholar
  19. 19.
    McAdam, A.J. et al. (2001)ICOS is critical for CD40-mediated antibody class switching. Nature 409, 102–105CrossRefGoogle Scholar
  20. 20.
    Bertram, E.M. et al. (2002)Role of ICOS versus CD28 in antiviral immunity. Eur J Immunol 32, 3376–3385Google Scholar
  21. 21.
    Keir, M.E., Francisco, L.M. Sharpe, A.H. (2007)PD-1 and its ligands in T-cell immunity. Curr Opin Immunol 19, 309–314CrossRefGoogle Scholar
  22. 22.
    Barber, D.L. et al. (2006)Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682–687CrossRefGoogle Scholar
  23. 23.
    Petrovas, C. et al. (2007)SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 110, 928–936CrossRefGoogle Scholar
  24. 24.
    Trautmann, L. et al. (2006)Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 12, 1198–1202CrossRefGoogle Scholar
  25. 25.
    Petrovas, C. et al. (2006)PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med 203, 2281–2292CrossRefGoogle Scholar
  26. 26.
    Day, C.L. et al. (2006)PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443, 350–354CrossRefGoogle Scholar
  27. 27.
    Zeng, C., Wu, T., Zhen, Y., Xia, X.P. Zhao, Y. (2005)BTLA, a new inhibitory B7 family receptor with a TNFR family ligand. Cell Mol Immunol 2, 427–432Google Scholar
  28. 28.
    Krieg, C., Boyman, O., Fu, Y.X. Kaye, J. (2007)B and T lymphocyte attenuator regulates CD8+ T cell-intrinsic homeostasis and memory cell generation. Nat Immunol 8, 162–171CrossRefGoogle Scholar
  29. 29.
    Yang, S.Y., Denning, S.M., Mizuno, S., Dupont, B. Haynes, B.F. (1988)A novel activation pathway for mature thymocytes. Costimulation of CD2 (T,p50) and CD28 (T,p44) induces autocrine interleukin 2/interleukin 2 receptor-mediated cell proliferation. J Exp Med 168, 1457–1468CrossRefGoogle Scholar
  30. 30.
    Gross, J.A., Callas, E. Allison, J.P. (1992)Identification and distribution of the costimulatory receptor CD28 in the mouse. J Immunol 149, 380–388Google Scholar
  31. 31.
    Nelson, A.J., Hosier, S., Brady, W., Linsley, P.S. Farr, A.G. (1993)Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro. J Immunol 151, 2453–2461Google Scholar
  32. 32.
    Degermann, S., Surh, C.D., Glimcher, L.H., Sprent, J. Lo, D. (1994)B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytes. J Immunol 152, 3254–3263Google Scholar
  33. 33.
    McKean, D.J. et al. (2001)Maturation versus death of developing double-positive thymocytes reflects competing effects on Bcl-2 expression and can be regulated by the intensity of CD28 costimulation. J Immunol 166, 3468–3475Google Scholar
  34. 34.
    Cibotti, R., Punt, J.A., Dash, K.S., Sharrow, S.O. Singer, A. (1997)Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals. Immunity 6, 245–255CrossRefGoogle Scholar
  35. 35.
    Punt, J.A., Osborne, B.A., Takahama, Y., Sharrow, S.O. Singer, A. (1994)Negative selection of CD4+ CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J Exp Med 179, 709–713CrossRefGoogle Scholar
  36. 36.
    Shahinian, A. et al. (1993)Differential T cell costimulatory requirements in CD28-deficient mice. Science 261, 609–612CrossRefGoogle Scholar
  37. 37.
    Tang, Q. et al. (2003)Cutting edge: CD28 controls peripheral homeostasis of CD4+ CD25+ regulatory T cells. J Immunol 171, 3348–3352Google Scholar
  38. 38.
    Tai, X., Cowan, M., Feigenbaum, L. Singer, A. (2005)CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol 6, 152CrossRefGoogle Scholar
  39. 39.
    Walunas, T.L., Sperling, A.I., Khattri, R., Thompson, C.B. Bluestone, J.A. (1996)CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance. J Immunol 156, 1006–1013Google Scholar
  40. 40.
    Yamada, H. et al. (1985)Monoclonal antibody 9.3 and anti-CD11 antibodies define reciprocal subsets of lymphocytes. Eur J Immunol 15, 1164–1168CrossRefGoogle Scholar
  41. 41.
    Pellat-Deceunynck, C. et al. (1994)Expression of CD28 and CD40 in human myeloma cells: a comparative study with normal plasma cells. Blood 84, 2597–2603Google Scholar
  42. 42.
    Kozbor, D., Moretta, A., Messner, H.A., Moretta, L. Croce, C.M. (1987)Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells. J Immunol 138, 4128–4132Google Scholar
  43. 43.
    Warrington, K.J., Vallejo, A.N., Weyand, C.M. Goronzy, J.J. (2003)CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation. Blood 101, 3543–3549CrossRefGoogle Scholar
  44. 44.
    Effros, R.B. et al. (1994)Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol 29, 601–609CrossRefGoogle Scholar
  45. 45.
    Posnett, D.N., Sinha, R., Kabak, S. Russo, C. (1994)Clonal populations of T cells in normal elderly humans: the T cell equivalent to “benign monoclonal gammapathy”. J Exp Med 179, 609–618CrossRefGoogle Scholar
  46. 46.
    Vallejo, A.N., Weyand, C.M. Goronzy, J.J. (2004)T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection. Trends Mol Med 10, 119–124CrossRefGoogle Scholar
  47. 47.
    Inaba, K. et al. (1994)The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med 180, 1849–1860CrossRefGoogle Scholar
  48. 48.
    Hathcock, K.S., Laszlo, G., Pucillo, C., Linsley, P. Hodes, R.J. (1994)Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J Exp Med 180, 631–640CrossRefGoogle Scholar
  49. 49.
    Frauwirth, K.A. et al. (2002)The CD28 signaling pathway regulates glucose metabolism. Immunity 16, 769–777CrossRefGoogle Scholar
  50. 50.
    Thompson, C.B. et al. (1989)CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc Natl Acad Sci USA 86, 1333–1337CrossRefGoogle Scholar
  51. 51.
    Bjorndahl, J.M., Sung, S.S., Hansen, J.A. Fu, S.M. (1989)Human T cell activation: differential response to anti-CD28 as compared to anti-CD3 monoclonal antibodies. Eur J Immunol 19, 881–887CrossRefGoogle Scholar
  52. 52.
    Lier, R.A., Van Brouwer, M. Aarden, L.A. (1988)Signals involved in T cell activation. T cell proliferation induced through the synergistic action of anti-CD28 and anti-CD2 monoclonal antibodies. Eur J Immunol 18, 167–172CrossRefGoogle Scholar
  53. 53.
    Appleman, L.J., Berezovskaya, A., Grass, I. Boussiotis, V.A. (2000)CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression. J Immunol 164, 144–151Google Scholar
  54. 54.
    Appleman, L.J., Puijenbroek, A.A., van Shu, K.M., Nadler, L.M. Boussiotis, V.A. (2002)CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. J Immunol 168, 2729–2736Google Scholar
  55. 55.
    Kirchhoff, S., Muller, W.W., Li-Weber, M. Krammer, P.H. (2000)Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-costimulated human T cells. Eur J Immunol 30, 2765–2774CrossRefGoogle Scholar
  56. 56.
    Sperling, A.I. et al. (1996)CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation. J Immunol 157, 3909–3917Google Scholar
  57. 57.
    Viola, A. Lanzavecchia, A. (1996)T cell activation determined by T cell receptor number and tunable thresholds. Science 273, 104–106CrossRefGoogle Scholar
  58. 58.
    Itoh, Y. Germain, R.N. (1997)Single cell analysis reveals regulated hierarchical T cell antigen receptor signaling thresholds and intraclonal heterogeneity for individual cytokine responses of CD4+ T cells. J Exp Med 186, 757–766CrossRefGoogle Scholar
  59. 59.
    Schwartz, R.H. (1990)A cell culture model for T lymphocyte clonal anergy. Science 248, 1349–1356CrossRefGoogle Scholar
  60. 60.
    Mueller, D.L., Jenkins, M.K. Schwartz, R.H. (1989)Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol 7, 445–480Google Scholar
  61. 61.
    Harding, F.A., McArthur, J.G., Gross, J.A., Raulet, D.H. Allison, J.P. (1992)CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 356, 607–609CrossRefGoogle Scholar
  62. 62.
    Nourse, J. et al. (1994)Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372, 570–573CrossRefGoogle Scholar
  63. 63.
    Boise, L.H. et al. (1995)CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity 3, 87–98CrossRefGoogle Scholar
  64. 64.
    Wu, L.X. et al. (2005)CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway. J Immunol 174, 180–194Google Scholar
  65. 65.
    Bajenoff, M. et al. (2007)Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node. Trends Immunol 28, 346–352CrossRefGoogle Scholar
  66. 66.
    Guermonprez, P., Valladeau, J., Zitvogel, L., Thery, C. Amigorena, S. (2002)Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol 20, 621–667CrossRefGoogle Scholar
  67. 67.
    Shahinian, A. et al. (1993)Differential T cell costimulatory requirements in CD28-deficient mice. Science 261, 609–612CrossRefGoogle Scholar
  68. 68.
    Suresh, M. et al. (2001)Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. J Immunol 167, 5565–5573Google Scholar
  69. 69.
    McAdam, A.J., Farkash, E.A., Gewurz, B.E. Sharpe, A.H. (2000)B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J Virol 74, 203–208CrossRefGoogle Scholar
  70. 70.
    Fuse, S. et al. (2006)CD80 and CD86 control antiviral CD8+ T-cell function and immune surveillance of murine gammaherpesvirus 68. J Virol 80, 9159–9170CrossRefGoogle Scholar
  71. 71.
    Lumsden, J.M., Roberts, J.M., Harris, N.L., Peach, R.J. Ronchese, F. (2000)Differential requirement for CD80 and CD80/CD86-dependent costimulation in the lung immune response to an influenza virus infection. J Immunol 164, 79–85Google Scholar
  72. 72.
    Bertram, E.M., Lau, P. Watts, T.H. (2002)Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. J Immunol 168, 3777–3785Google Scholar
  73. 73.
    Halstead, E.S., Mueller, Y.M., Altman, J.D. Katsikis, P.D. (2002)In vivo stimulation of CD137 broadens primary antiviral CD8(+) T cell responses. Nat Immunol 3, 536–541CrossRefGoogle Scholar
  74. 74.
    Liu, Y., Wenger, R.H., Zhao, M. Nielsen, P.J. (1997)Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes. J Exp Med 185, 251–262CrossRefGoogle Scholar
  75. 75.
    Kundig, T.M. et al. (1996)Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity 5, 41–52CrossRefGoogle Scholar
  76. 76.
    Sprent, J. Surh, C.D. (2002)T cell memory. Annu Rev Immunol 20, 551–579CrossRefGoogle Scholar
  77. 77.
    Curtsinger, J.M., Lins, D.C. Mescher, M.F. (1998)CD8+ memory T cells (CD44high, Ly-6C+) are more sensitive than naive cells to (CD44low, Ly-6C. −) to TCR/CD8 signaling in response to antigen J Immunol160, 3236–3243Google Scholar
  78. 78.
    Bachmann, M.F. et al. (1999)Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells. J Exp Med 189, 1521–1530CrossRefGoogle Scholar
  79. 79.
    Kim, S.K., Schluns, K.S. Lefrancois, L. (1999)Induction and visualization of mucosal memory CD8 T cells following systemic virus infection. J Immunol 163, 4125–4132Google Scholar
  80. 80.
    Bertram, E.M. et al. (2004)A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo. J Immunol 172, 981–988Google Scholar
  81. 81.
    Flynn, K. Mullbacher, A. (1996)memory alloreactive cytotoxic T cells do not require costimulation for activation in vitro. Immunol Cell Biol 74, 413–420CrossRefGoogle Scholar
  82. 82.
    Croft, M., Bradley, L.M. Swain, S.L. (1994)Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J Immunol 152, 2675–2685Google Scholar
  83. 83.
    Altman, J.D. et al. (1996)Phenotypic analysis of antigen-specific T lymphocytes. Science 274, 94–96CrossRefGoogle Scholar
  84. 84.
    London, C.A., Lodge, M.P. Abbas, A.K. (2000)Functional responses and costimulator dependence of memory CD4+ T cells. J Immunol 164, 265–272Google Scholar
  85. 85.
    Borowski, A.B. et al. (2007)Memory CD8+ T cells require CD28 costimulation. J Immunol 179, 6494–6503Google Scholar
  86. 86.
    Belz, G.T. et al. (2006)Bone marrow-derived cells expand memory CD8+ T cells in response to viral infections of the lung and skin. Eur J Immunol 36, 327–335CrossRefGoogle Scholar
  87. 87.
    Zammit, D.J., Cauley, L.S., Pham, Q.M. Lefrancois, L. (2005)Dendritic cells maximize the memory CD8 T cell response to infection. Immunity 22, 561–570CrossRefGoogle Scholar
  88. 88.
    Ndejembi, M.P. et al. (2006)Control of memory CD4 T cell recall by the CD28/B7 costimulatory pathway. J Immunol 177, 7698–7706Google Scholar
  89. 89.
    Bevan, M.J. Fink, P.J. (2001)The CD8 response on autopilot. Nat Immunol 2, 381–382Google Scholar
  90. 90.
    Kaech, S.M. Ahmed, R. (2001)Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat Immunol 2, 415–422Google Scholar
  91. 91.
    Murali-Krishna, K. et al. (1998)Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8, 177–187CrossRefGoogle Scholar
  92. 92.
    Prilliman, K.R. et al. (2002)Cutting edge: a crucial role for B7-CD28 in transmitting T help from APC to CTL. J Immunol 169, 4094–4097Google Scholar
  93. 93.
    Grayson, J.M., Zajac, A.J., Altman, J.D. Ahmed, R. (2000)Cutting edge: increased expression of Bcl-2 in antigen-specific memory CD8+ T cells. J Immunol 164, 3950–3954Google Scholar
  94. 94.
    Schmitt, C.A. (2003)Senescence, apoptosis and therapy – cutting the lifelines of cancer. Nat Rev Cancer 3, 286–295CrossRefGoogle Scholar
  95. 95.
    Chen, Q.M., Liu, J. Merrett, J.B. (2000)Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts. Biochem J 347, 543–551CrossRefGoogle Scholar
  96. 96.
    Sasaki, M., Kumazaki, T., Takano, H., Nishiyama, M. Mitsui, Y. (2001)Senescent cells are resistant to death despite low Bcl-2 level. Mech Ageing Dev 122, 1695–1706CrossRefGoogle Scholar
  97. 97.
    Kim, R. (2005)Unknotting the roles of Bcl-2 and Bcl-xL in cell death. Biochem Biophys Res Commun 333, 336–343CrossRefGoogle Scholar
  98. 98.
    Servet-Delprat, C. et al. (2000)Measles virus induces abnormal differentiation of CD40 ligand-activated human dendritic cells. J Immunol 164, 1753–1760Google Scholar
  99. 99.
    Morrow, G., Slobedman, B., Cunningham, A.L. Abendroth, A. (2003)Varicella-zoster virus productively infects mature dendritic cells and alters their immune function. J Virol 77, 4950–4959CrossRefGoogle Scholar
  100. 100.
    Chaudhry, A. et al. (2005)The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs. J Immunol 175, 4566–4574Google Scholar
  101. 101.
    Majumder, B. et al. (2005)Human immunodeficiency virus type 1 Vpr impairs dendritic cell maturation and T-cell activation: implications for viral immune escape. J Virol 79, 7990–8003CrossRefGoogle Scholar
  102. 102.
    Dong, H. et al. (2002)Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 8, 793–800Google Scholar
  103. 103.
    Gabrilovich, D.I. et al. (1996)Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 2, 1096–1103CrossRefGoogle Scholar
  104. 104.
    Gabrilovich, D. et al. (1998)Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92, 4150–4166Google Scholar
  105. 105.
    Brown, J.A. et al. (2003)Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol 170, 1257–1266Google Scholar
  106. 106.
    Curiel, T.J. et al. (2003)Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 9, 562–567CrossRefGoogle Scholar
  107. 107.
    Leach, D.R., Krummel, M.F. Allison, J.P. (1996)Enhancement of antitumor immunity by CTLA-4 blockade. Science 271, 1734–1736CrossRefGoogle Scholar
  108. 108.
    Abrams, J.R. et al. (1999)CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J Clin Invest 103, 1243–1252CrossRefGoogle Scholar
  109. 109.
    Kremer, J.M. et al. (2003)Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 349, 1907–1915CrossRefGoogle Scholar
  110. 110.
    Genovese, M.C. et al. (2005)Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N Engl J Med 353, 1114–1123CrossRefGoogle Scholar
  111. 111.
    Guinan, E.C. et al. (1999)Transplantation of anergic histoincompatible bone marrow allografts. N Engl J Med 340, 1704–1714CrossRefGoogle Scholar
  112. 112.
    Adams, A.B. et al. (2003)Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest 111, 1887–1895Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Christine M. Bucks
    • 1
  • Peter D. Katsikis*
  1. 1.Department of Microbiology and ImmunologyDrexel University College of MedicinePhiladelphiaUSA

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