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Initial TCR transgenic precursor frequency alters functional behaviour of CD8 T cells responding to acute infection

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Crossroads between Innate and Adaptive Immunity II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 633))

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References

  1. Altman, J.D., Moss, P.A., Goulder, P.J., Barouch, D.H., McHeyzer-Williams, M.G., Bell, J.I., McMichael, A.J., Davis, M.M. (1996). Phenotypic analysis of antigen-specific T lymphocytes. Science 274, 94–96

    Article  Google Scholar 

  2. Badovinac, V.P., Haring, J.S., Harty, J.T. (2007). Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection. Immunity 26, 827–841

    Article  Google Scholar 

  3. Badovinac, V.P., Harty, J.T. (2006). Programming, demarcating, and manipulating CD8+ T-cell memory. Immunological Reviews 211, 67–80

    Article  Google Scholar 

  4. Baron, V., Bouneaud, C., Cumano, A., Lim, A., Arstila, T.P., Kourilsky, P., Ferradini, L., Pannetier, C. (2003). The repertoires of circulating human CD8(+) central and effector memory T cell subsets are largely distinct. Immunity 18, 193–204

    Article  Google Scholar 

  5. Blattman, J.N., Antia, R., Sourdive, D.J., Wang, X., Kaech, S.M., Murali-Krishna, K., Altman, J.D., Ahmed, R. (2002). Estimating the precursor frequency of naive antigen-specific CD8 T cells. Journal of Experimental Medicine 195, 657–664

    Article  Google Scholar 

  6. Bousso, P., Casrouge, A., Altman, J.D., Haury, M., Kanellopoulos, J., Abastado, J.P., Kourilsky, P. (1998). Individual variations in the murine T cell response to a specific peptide reflect variability in naive repertoires. Immunity 9, 169–178

    Article  Google Scholar 

  7. Bousso, P., Robey, E. (2003). Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes. Nature Immunology 4, 579–585

    Article  Google Scholar 

  8. Butz, E.A., Bevan, M.J. (1998). Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity 8, 167–175

    Article  Google Scholar 

  9. Casrouge, A., Beaudoing, E., Dalle, S., Pannetier, C., Kanellopoulos, J., Kourilsky, P. (2000). Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes. Journal of Immunology 164, 5782–5787

    Google Scholar 

  10. Ford, M.L., Koehn, B.H., Wagener, M.E., Jiang, W., Gangappa, S., Pearson, T.C., Larsen, C.P. (2007). Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation. Journal of Experimental Medicine 204, 299–309

    Article  Google Scholar 

  11. Foulds, K.E., Shen, H. (2006). Clonal competition inhibits the proliferation and differentiation of adoptively transferred TCR transgenic CD4 T cells in response to infection. Journal of Immunology 176, 3037–3043

    Google Scholar 

  12. Foulds, K.E., Zenewicz, L.A., Shedlock, D.J., Jiang, J., Troy, A.E., Shen, H. (2002). Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. Journal of Immunology 168, 1528–1532

    Google Scholar 

  13. Hataye, J., Moon, J.J., Khoruts, A., Reilly, C., Jenkins, M.K. (2006). Naive and memory CD4+ T cell survival controlled by clonal abundance. Science 312, 114–116

    Article  Google Scholar 

  14. Heath, W.R., Belz, G.T., Behrens, G.M., Smith, C.M., Forehan, S.P., Parish, I.A., Davey, G.M., Wilson, N.S., Carbone, F.R., Villadangos, J.A. (2004). Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Immunological Reviews 199, 9–26

    Article  Google Scholar 

  15. Huster, K.M., Busch, V., Schiemann, M., Linkemann, K., Kerksiek, K.M., Wagner, H., Busch, D.H. (2004). Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. Proceedings of the National Academy of Sciences of the United States of America 101, 5610–5615

    Article  Google Scholar 

  16. Kaech, S.M., Ahmed, R. (2001). Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nature Immunology 2, 415–422

    Google Scholar 

  17. Kaech, S.M., Tan, J.T., Wherry, E.J., Konieczny, B.T., Surh, C.D., Ahmed, R. (2003). Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nature Immunology 4, 1191–1198

    Article  Google Scholar 

  18. Kearney, E.R., Pape, K.A., Loh, D.Y., Jenkins, M.K. (1994). Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1, 327–339

    Article  Google Scholar 

  19. Kedzierska, K., Day, E.B., Pi, J., Heard, S.B., Doherty, P.C., Turner, S.J., Perlman, S. (2006). Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage. Journal of Immunology 177, 6705–6712

    Google Scholar 

  20. Kemp, R.A., Powell, T.J., Dwyer, D.W., Dutton, R.W. (2004). Cutting edge: regulation of CD8+ T cell effector population size. Journal of Immunology 173, 2923–2927

    Google Scholar 

  21. Lanzavecchia, A., Sallusto, F. (2000). Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells. Science 290, 92–97

    Article  Google Scholar 

  22. Marzo, A.L., Klonowski, K.D., Le Bon, A., Borrow, P., Tough, D.F., Lefrancois, L. (2005). Initial T cell frequency dictates memory CD8+ T cell lineage commitment. Nature Immunology 6, 793–799

    Article  Google Scholar 

  23. Masopust, D., Vezys, V., Marzo, A.L., Lefrancois, L. (2001). Preferential localization of effector memory cells in nonlymphoid tissue. Science 291, 2413–2417

    Article  Google Scholar 

  24. Mempel, T.R., Henrickson, S.E., Andrian, U.H. Von (2004). T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427, 154–159

    Article  Google Scholar 

  25. Moon, J.J., Chu, H.H., Pepper, M., McSorley, S.J., Jameson, S.C., Kedl, R.M., Jenkins, M.K. (2007). Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27, 203–213

    Article  Google Scholar 

  26. Pewe, L.L., Netland, J.M., Heard, S.B., Perlman, S. (2004). Very diverse CD8 T cell clonotypic responses after virus infections. Journal of Immunology 172, 3151–3156

    Google Scholar 

  27. Reiner, S.L., Sallusto, F., Lanzavecchia, A. (2007). Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate. Science 317, 622–625

    Article  Google Scholar 

  28. Sallusto, F., Lenig, D., Forster, R., Lipp, M., Lanzavecchia, A. (1999). Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708–712

    Article  Google Scholar 

  29. Stoll, S., Delon, J., Brotz, T.M., Germain, R.N. (2002). Dynamic imaging of T cell–dendritic cell interactions in lymph nodes. Science 296, 1873–1876

    Article  Google Scholar 

  30. Wherry, E.J., Teichgraber, V., Becker, T.C., Masopust, D., Kaech, S.M., Antia, R., Andrian, U.H., von Ahmed, R. (2003). Lineage relationship and protective immunity of memory CD8 T cell subsets. Nature Immunology 4, 225–234

    Article  Google Scholar 

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Wirth, T., Harty, J.T. (2009). Initial TCR transgenic precursor frequency alters functional behaviour of CD8 T cells responding to acute infection. In: Schoenberger, S., Katsikis, P., Pulendran, B. (eds) Crossroads between Innate and Adaptive Immunity II. Advances in Experimental Medicine and Biology, vol 633. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79311-5_7

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