DETECTION OF MICROBES BY NATURAL KILLER T CELLS
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Natural killer T (NKT) cells combine features of the innate and adaptive immune systems. For example, they are lymphocytes that express an αβ T cell antigen receptor (TCR), typical of adaptive immunity, but they also express NK receptors, such as NK1.1 (NKR-P1 or CD161c), similar to NK cells, which are part of the innate immune system.1, 2 In mice, the majority of NKT cells express an invariant (i) TCRα chain with Vα14–Jα18 rearrangement.1, 2 We refer to these lymphocytes here as Vα14iNKT cells. These cells have a limited repertoire of TCRβ chains, mainly Vβ8.2, Vβ7, and Vβ2, with the highest representation of Vβ8.2 (more than 50%). Humans have a similar population that mostly expresses an invariant Vα24–Jα18 rearrangement with Vβ11 (Vα24iNKT).1, 2 We refer to these two populations in mice and humans as iNKT cells.
iNKT cells have several unique features. In contrast to conventional T cells that recognize peptide antigens presented by major histocompatibility complex...
KeywordsiNKT Cell Borrelia Burgdorferi Microbial Antigen Lipid Antigen Glycolipid Antigen
This work was supported by NIH grants R37 AI71922, RO1 AI45053, RO1 AI69276 (MK), and a fellowship from The Irvington Institute Fellowship Program of the Cancer Research Institute Research (Y.K.).
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