THE NK/DC COMPLOT
Different NK cell subsets exist that display major functional differences in their cytolytic activity, cytokine production, and homing capabilities. In particular, CD56high CD16− NK cells, which largely predominate in lymph nodes, have little cytolytic activity but release high levels of cytokines; whereas CD56low CD16+ NK cells, which predominate in peripheral blood and inflamed tissues, display lower cytokine production but potent cytotoxicity.1 Various cell types that are resident within peripheral tissues as well as circulating cells that have been recruited in response to chemokine gradients into inflamed sites are equipped with receptors for pathogen-associated products that induce cytokine release upon engagement by their specific ligands. These cytokines directly influence the ability of NK cells to modulate both innate and adaptive immune responses.2For example, innate cytokines such as IL12 and IL18, produced by antigen presenting cells (APCs) including...
KeywordsCytolytic Activity Intracellular Perforin CD56low CD16 Encounter Target Cell
This work was supported by grants awarded by Associazione Italiana per la Ricerca sul Cancro (A.I.R.C.), Istituto Superiore di Sanità (I.S.S.), Ministero della Salute – RF 2002/149, Ministero dell’Istruzione dell’Università e della Ricerca (M.I.U.R.), FIRB-MIUR progetto-cod.RBNE017B4C, Ministero dell’Università e della Ricerca Scientifica e Tecnologica (M.U.R.S.T.), European Union FP6, LSHB-CT-2004-503319-Allostem, and Compagnia di San Paolo.
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