• Erika D. Reynoso
  • Je-Wook Lee
  • Shannon J. Turley*
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 633)

1 Introduction

T cell tolerance to self-antigens is of utmost importance to prevent autoimmune attack against self. Failure of T cell tolerance induction inevitably leads to autoimmune disease, as is the case in type-1 diabetes, rheumatoid arthritis, and multiple sclerosis, for example. Fortunately, multiple mechanisms have evolved to enforce self–nonself discrimination among T cells. Such mechanisms act to eliminate self-reactive T cells in the thymus and to eliminate or silence self-reactive T cells, which have escaped thymic selection, in the periphery.

Our current thinking of tolerance induction in the periphery has been shaped by the idea that resting lymph node-resident dendritic cells (DCs) crosspresent tissue-derived self-antigens to CD8+T cells and incite their elimination. However, recent work by several groups has highlighted a role for nonhematopoietic lymph node stromal cells (LNSCs), with characteristics similar to both medullary thymic epithelial cells (mTECs) and...


Costimulatory Molecule Tolerance Induction Cell Tolerance Peripheral Lymph Node Autoimmune Regulator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Erika D. Reynoso
    • 1
  • Je-Wook Lee
  • Shannon J. Turley*
  1. 1.Department of Pathology, Harvard Medical School and Department of Cancer Immunology and AIDSDana-Farber Cancer InstituteBostonUSA

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