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PERIPHERAL TOLERANCE INDUCTION BY LYMPH NODE STROMA

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Crossroads between Innate and Adaptive Immunity II

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References

  1. Adler, A.J., Marsh, D.W., Yochum, G.S., Guzzo, J.L., Nigam, A., Nelson, W.G., Pardoll, D.M.,1998, CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone-marrow-derived antigen-presenting cells,: J. Exp. Med. 1871555

    Article  PubMed  CAS  Google Scholar 

  2. Akbari, O., DeKruyff, R.H., Umetsu, D.T., 2001, Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen, Nat. Immunol. 2:725

    Article  PubMed  CAS  Google Scholar 

  3. Albert, M., Jegathesan, M., Darnell, R.B., 2001, Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells, Nat. Immunol. 2:1010

    Article  PubMed  CAS  Google Scholar 

  4. Anderson, A.O. Shaw, S., 2005, Conduit for privileged communications in the lymph node, Immunity 22:3

    Article  PubMed  CAS  Google Scholar 

  5. Anderson, M.S., Venanzi, E.S., Chen, Z., Berzins, S.P., Benoist, C., Mathis, D., 2005, The cellular mechanism of Aire control of T cell tolerance, Immunity 23:227

    Article  PubMed  CAS  Google Scholar 

  6. Anderson, M.S., Venanzi, E.S., Klein, L., Chen, Z., Berzins, S.P., Turley, S.J., Boehmer, H., von Bronson, R., Dierich, A., Benoist, C., Mathis, D., 2002, Projection of an immunological self shadow within the thymus by the Aire protein, Science 298:1395

    Article  PubMed  CAS  Google Scholar 

  7. Azukizawa, H., Kosaka, H., Sano, S., Heath, W.R., Takahashi, I., Gao, X.H., Sumikawa, Y., Okabe, M., Yoshikawa, K., Itami, S., 2003, Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes, Eur. J. Immunol. 33:1879

    Article  PubMed  CAS  Google Scholar 

  8. Bajenoff, M., Egen, J.G., Koo, L.Y., Laugier, J.P., Brau, F., Glaichenhaus, N., Germain, R.N., 2006, Stromal cell networks regulate lymphocyte entry migration and territoriality in lymph nodes, Immunity 25:989

    Article  PubMed  CAS  Google Scholar 

  9. Belz, G.T., Behrens, G.M.N., Smith, C.M., Miller, J.F.A.P., Jones, C., Lejon, K., Fathman, C.G., Mueller, S.N., Shortman, K., Carbone, F.R., Heath, W.R., 2002, The CD8?+ dendritic cell subset is responsible for inducing peripheral self-tolerance to tissue-associated antigens, J. Exp. Med. 196:1099

    Article  PubMed  CAS  Google Scholar 

  10. Benson, M.J., Pino-Lagos, K., Rosemblatt, M., Noelle, R.J., 2007, All-trans retinoic acid mediates enhanced T-reg cell growth,differentiation, and gut homing in the face of high levels of co-stimulation, J. Exp. Med. 204:1765

    Article  PubMed  CAS  Google Scholar 

  11. Bonasio, R., Scimone, M.L., Schaerli, P., Grabie, N., Lichtman, A.H., Andrian, U.H., von 2006, Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus, Nat. Immunol. 7:1092

    Article  PubMed  CAS  Google Scholar 

  12. Breiteneder-Geleff, S., Soleiman, A., Kowalski, H., Horvat, R., Amann, G., Kriehuber, E., Diem, K., Weninger, W., Tschachler, E., Alitalo, K., Kerjaschki, D., 1999, Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries, Am. J. Pathol. 154:385

    PubMed  CAS  Google Scholar 

  13. Chieppa, M., Rescigno, M., Huang, A.Y.C., Germain, R.N., 2006, Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement, J. Exp. Med. 203:2841

    Article  PubMed  CAS  Google Scholar 

  14. Coombes, J.L., Siddiqui, K.R.R., Arancibia-Carcamo, C., Hall, J., Sun, C.M., Belkaid, Y., Powrie, F., 2007, A functionally specialized population of mucosal CD103+ DCs induces FoxP3+ regulatory T cells via a TGF-?- and retinoic acid-dependent mechanism, J. Exp. Med. 204:1757

    Article  PubMed  CAS  Google Scholar 

  15. Denning, T.L., Wang, Y., Patel, S.R., Williams, I.R., Pulendran, B., 2007, Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses, Nat. Immunol. 8:1086

    Article  PubMed  CAS  Google Scholar 

  16. Derbinski, J., Schulte, A., Kyewski, B., Klein, L., 2001, Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self, Nat. Immunol. 2:1032

    Article  PubMed  CAS  Google Scholar 

  17. Farr, A.G., Berry, M.L., Kim, A., Nelson, A.J., Welch, M.P., Aruffo, A., 1992, Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues, J. Exp. Med. 176:1477

    Article  PubMed  CAS  Google Scholar 

  18. Gallegos, A.M Bevan, M.J., 2004Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation, J. Exp. Med. 200:1039

    Article  PubMed  CAS  Google Scholar 

  19. Gallegos, A.M. Bevan, M.J., 2006, Central tolerance: good but imperfect, Immunol. Rev. 209:290

    Article  PubMed  Google Scholar 

  20. Garcia, C.A., Prabakar, K.R., Diez, J., Cao, Z.A., Allende, G., Zeller, M., Dogra, R., Mendez, A., Rosenkranz, E., Dahl, U., Ricordi, C., Hanahan, D., Pugliese, A., 2005, Dendritic cells in human thymus and periphery display a proinsulin epitope in a transcription-dependent, capture-independent fashion, J. Immunol. 175:2111

    CAS  Google Scholar 

  21. Gretz, J.E., Anderson, A.O., Shaw, S., 1997, Cords, channels, corridors, and conduits: critical architectural elements facilitating cell interaction in the lymph node corex, Immunol. Rev. 156:11

    Article  PubMed  CAS  Google Scholar 

  22. Gretz, J.E., Kaldjian, E.P., Anderson, A.O., Shat, S., 1996, Sophisticated strategies for information encounter in the lymph node – the reticular network as a conduit of soluble information and a highway for cell traffic, J. Immunol. 157:495

    PubMed  CAS  Google Scholar 

  23. Gretz, J.E., Norbury, C.C., Anderson, A.O., Proudfoot, A.E.I., Shaw, S., 2000, Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironment in lymph node cortex, J. Exp. Med. 192:1425

    Article  PubMed  CAS  Google Scholar 

  24. Heath, W.R., Belz, G.T., Behrens, G.M.N., Smith, C.M., Forehan, S.P., Parish, I.A., Davey, G.M., Wilson, N.S., Carbone, F.R., Villadangos, J.A., 2004, Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens, Immunol. Rev. 199:9

    Article  PubMed  CAS  Google Scholar 

  25. Hugues, S., Fetler, L., Bonifaz, L., Helft, J., Amblard, F., Amigorena, S., 2004, Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity, Nat. Immunol. 5:1235

    Article  PubMed  CAS  Google Scholar 

  26. Kataki, T., Hara, T., Sugai, M., Gonda, H., Shimizu, A., 2004, Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J. Exp. Med. 200:783

    Article  Google Scholar 

  27. Keir, M.E., Freeman, G.J., and Sharpe, A.H., 2007, PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues, J. Immunol. (in press )<bib id="bib27_10"> <no>27</no> <otherref>. Keir, M.E., Freeman, G.J., and Sharpe, A.H., 2007, PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues, J. Immunol. (in press )</otherref> </bib>

    Google Scholar 

  28. Keir, M.E., Liang, S.C., Guleria, I., Latchman, Y.E., Qipo, A., Albacker, L.A., Koulmanda, M., Freeman, G.J., Sayegh, M.H., Sharpe, A.H., 2006, Tissue expression of PD-L1 mediates peripheral T cell tolerance, J. Exp. Med. 203:883

    Article  PubMed  CAS  Google Scholar 

  29. Kleindienst, P., Wiethe, C., Lutz, M.B., Brocker, T., 2005, Simultaneous induction of CD4 T cell tolerance and CD8 T cell immunity by semimature dendritic cells, J. Immunol. 174:3941

    PubMed  CAS  Google Scholar 

  30. Kurts, C., Heath, W.R., Carbone, F.R., Allison, J., Miller, J.F.A.P., Kosaka, H., 1996, Constitutive class I-restricted exogenous presentation of self antigens in vivo, J. Exp. Med. 184:923

    Article  PubMed  CAS  Google Scholar 

  31. Kurts, C., Kosaka, H., Carbone, F.R., Miller, J.F.A.P., Heath, W.R., 1997, Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8+ T cells, J. Exp. Med. 186:239

    Article  PubMed  CAS  Google Scholar 

  32. Lee, J.W., Epardaud, M., Sun, J., Becker, J.E., Cheng, A.C., Yonekura, A., Heath, J.K., Turley, S.J., 2007, Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self, Nat. Immunol. 8:181

    Article  PubMed  CAS  Google Scholar 

  33. Liang, S.C., Latchman, Y.E., Buhlmann, J.E., Tomczak, M.F., Horwitz, B.H., Freeman, G.J., Sharpe, A.H., 2003, Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses, Eur. J. Immunol. 33:2706

    Article  PubMed  CAS  Google Scholar 

  34. Link, A., Vogt, T.K., Favre, S., Britschgi, M.R., Acha-Orbea, H., Hinz, B., Cyster, J.G., and Luther, S.A., 2007, Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naïve T cells, Nat. Immunol. (published online)<bib id="bib34_10"> <no>34</no> <otherref>. Link, A., Vogt, T.K., Favre, S., Britschgi, M.R., Acha-Orbea, H., Hinz, B., Cyster, J.G., and Luther, S.A., 2007, Fibroblastic reticular cells in lymph nodes regulate the homeostasis of na&#x00EF;ve T cells, Nat. Immunol. (published online)</otherref> </bib>

    Google Scholar 

  35. Lutz, M.B. Schuler, G., 2002, Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 23:445

    Article  PubMed  CAS  Google Scholar 

  36. Macpherson, A.J., Uhr, T., 2004, Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria, Science 303:1662

    Article  PubMed  CAS  Google Scholar 

  37. Mayerova, D., Parke, E.A., Bursch, L.S., Odumade, O.A., Hogquist, K.A., 2004, Langerhans cells activate naïve self-antigen-specific CD8 T cells in the steady state, Immunity 21:391

    Article  PubMed  CAS  Google Scholar 

  38. McGargill, M.A., Mayerova, D., Stefanski, H.E., Koehn, B., Parke, E.A., Jameson, S.C., Panoskaltsis-Mortari, A., Hogquist, K.A., 2002, A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter, J. Immunol. 169:2141

    PubMed  CAS  Google Scholar 

  39. McGirk, P., McCann, C., Mills, H.G., 2002, Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis, J. Exp. Med. 195:221

    Article  Google Scholar 

  40. Melief, C.J.M.,2003, Regulation of cytotoxic T lymphocyte responses by dendritic cells: peaceful coexistence of cross-priming and direct-priming? Eur. J. Immunol. 33:2645

    Article  PubMed  CAS  Google Scholar 

  41. Menges, M., Rössner, S., Voigtländer, C., Schindler, H., Kukutsch, N.A., Bogdan, C., Erb, K., Schuler, G., Lutz, H., 2002, Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity, J. Exp. Med. 195:15

    Article  PubMed  CAS  Google Scholar 

  42. Morgan, D.J., Kurts, C., Kreuwel, H.T.C., Holst, K.L., Heath, W.R., Sherman, L.A., 1999, Ontogeny of T cell tolerance to peripherally expressed antigens, Proc. Natl Acad. Sci. USA 96:3854

    Article  PubMed  CAS  Google Scholar 

  43. Moser, M.,2003, Dendritic cells in immunity and tolerance-do they display opposite functions? Immunity 19:5

    Article  PubMed  CAS  Google Scholar 

  44. Mowat, A.M., 2003, Anatomical basis of tolerance and immunity to intestinal antigens, Nat. Rev. 3:331

    Article  CAS  Google Scholar 

  45. Nagler-Anderson, C., 2001, Man the barrier! Strategic defenses in the intestinal mucosa, Nat. Rev. 1:59

    Article  CAS  Google Scholar 

  46. Nichols, L.A., Chen, Y., Colella, T.A., Bennett, C.L., Clausen, B.E., Engelhard, V.H., 2007, Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes, J. Immunol. 179:993

    PubMed  CAS  Google Scholar 

  47. Niess, J.H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B.A., Vyas, J.M., Boes, M., Ploegh, H.L., Fox, J.G., Littman, D.R., Reinecker, H.C., 2005, CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance, Science 307:254

    Article  PubMed  CAS  Google Scholar 

  48. Palmer, E., 2003, Negative selection – clearing out the bad apples from the T-cell repertoire, Nat. Immunol. 3:383

    Article  CAS  Google Scholar 

  49. Probst, H.C., Lagnel, J., Kollias, G., Broek, M., van den 2003, Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance, Immunity 18:713

    Article  PubMed  CAS  Google Scholar 

  50. Probst, H.C., McCoy, K., Okazaki, T., Honjo, T., Broek, M., van den 2005, Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4, Nat. Immunol. 6:280

    Article  PubMed  CAS  Google Scholar 

  51. Pugliese, A., Brown, D., Garza, D., Murchison, D., Zeller, M., Redondo, M., Diez, J., Eisenbarth, G.S., Patel, D.D., Ricordi, C., 2001, Self-antigen presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs, J. Clin. Invest. 107:555

    Article  PubMed  CAS  Google Scholar 

  52. Redmond, W.L. Sherman, L.S., 2005, Peripheral tolerance of CD8+ lymphocytes, Immunity 22:275

    Article  PubMed  CAS  Google Scholar 

  53. Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.P., Ricciardi-Castagnoli, P., 2001, Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria, Nat. Immunol. 2:361

    Article  PubMed  CAS  Google Scholar 

  54. Rimoldi, M., Chieppa, M., Salucci, V., Avogadri, F., Sonzogni, A., Sampietro, G.M., Nespoli, A., Viale, G., Allavena, P., Rescigno, M., 2005, Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells, Nat. Immunol. 6:507

    Article  PubMed  CAS  Google Scholar 

  55. Schacht, V., Dadras, S.S., Johhson, L.A., Jackson, D.G., Hong, Y.K., Detmar, M., 2005, Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors, Am. J. Pathol. 166:913

    PubMed  CAS  Google Scholar 

  56. Scheinecker, C., McHugh, R., Shevach, E.M., Germain, R.N., 2002, Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node, J. Exp. Med. 196:1079

    Article  PubMed  CAS  Google Scholar 

  57. Sixt, M., Kanazawa, N., Selg, M., Samson, T., Roos, G., Reinhardt, D.P., Pabst, R., Lutz, M.B., Sorokin, L., 2005, The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node, Immunity 22:19

    Article  PubMed  CAS  Google Scholar 

  58. Steinman, R.M., Hawiger, D., Liu, K., Bonifaz, L., Bonnyay, D., Mahnke, K., Iyoda, T., Ravetech, J., Dhodapkar, M., Inaba, K., Nussenzweig, M., 2003, Dendritic cell function in vivo during the steady state: a role in peripheral tolerance, Ann. N.Y. Acad. Sci. 987:15

    Article  PubMed  CAS  Google Scholar 

  59. Steinman, R.M., Hawiger, D., Nussenzweig, M., 2003, Tolerogenic dendritic cells, Annu. Rev. Immunol. 21:685

    Article  PubMed  CAS  Google Scholar 

  60. Sun, C.M., Hall, J.A., Blank, R.B., Bouladoux, N., Oukka, M., Mora, J.R., Belkaid, Y., 2007, Small intestine lamina propria dendritic cells promote de novo generation of FoxP3+ T reg cells via retinoic acid, J. Exp. Med. 204:1775

    Article  PubMed  CAS  Google Scholar 

  61. Vliet, E., van Melis, M., Foidart, J.M., Ewijk, W., van 1986, Reticular fibroblasts in peripheral lymphoid organs identified by a monoclonal antibody, J. Histochem. Cytochem. 34:883

    PubMed  Google Scholar 

  62. Vezys, V., Olson, S., Lefrançois, L., 2000, Expression of intestine-specific antigen reveals novel pathways of CD8+ T cell tolerance induction, Immunity 12:505

    Article  PubMed  CAS  Google Scholar 

  63. Yamazaki, T., Akiba, H., Iwai, H., Matsuda, H., Aoki, M., Tanno, Y., Shin, T., Tsuchiya, H., Pardoll, D.M., Okumara, K., Azuma, M., Yagita, H., 2002, Expression of programmed death 1 ligands by murine T cells and APC, J. Immunol. 169:5538

    PubMed  CAS  Google Scholar 

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Reynoso, E.D., Lee, JW., Turley*, S.J. (2009). PERIPHERAL TOLERANCE INDUCTION BY LYMPH NODE STROMA. In: Schoenberger, S., Katsikis, P., Pulendran, B. (eds) Crossroads between Innate and Adaptive Immunity II. Advances in Experimental Medicine and Biology, vol 633. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79311-5_10

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