THE PROTECTIVE EFFECTS OF TYPE-1 INTERFERON IN MODELS OF INTESTINAL INFLAMMATION
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Inflammatory bowel disease (IBD) including both Crohn’s disease and ulcerative colitis is characterized by episodes of intestinal inflammation that can reoccur throughout life. Clinical and experimental evidence suggests that the etiology of IBD is multifactorial and includes susceptibility genes related to innate immunity (e.g., Nod2, IL-23R) as well as environmental factors,4, 5, 6,10,13,14 such as exposure to intestinal microflora and/or their products. It is believed that the interaction of these factors with the immune system leads to dysregulated mucosal immunity and chronic intestinal inflammation. Different models of experimental colitis have been instrumental in defining the fundamental molecular mechanisms and cellular interplay that lead to colonic inflammation in mice as well as humans.
The acute colitis that is induced in mice by a single oral administration of dextran sulfate sodium (DSS) is the result of a T cell independent inflammatory reaction. This...
KeywordsInflammatory Bowel Disease Dextran Sulfate Sodium Intestinal Inflammation TLR9 Ligand Diphtheria Toxin
This work was supported by NIH grants AI40682, AI68685, DK35108 and a grant from the CCFA. We thank Mrs. L. Beck for her editorial assistance.
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