Neuroimaging Biomarkers in Schizophrenia

  • Heike Tost
  • Andreas Meyer-Lindenberg


Schizophrenia is a highly heritable and devastating mental disorder with a complex genetic architecture. The combination of multimodal neuroimaging with genetic mapping techniques and the subsequent assessment of genomic variation (“imaging genetics”) has recently proved to be exceptionally powerful in advancing our understanding of the neural underpinnings of normal cognition and mental disease states. This upcoming research field has opened doors to a previously inaccessible level of both biological characterization and the validation of schizophrenia risk gene effects. This chapter reviews the current scientific knowledge on neuroimaging biomarkers in schizophrenia and illustrates the major conceptual change in the way in which biological intermediate phenotypes are viewed and pursued in psychiatry today.


Diffusion Tensor Imaging Atypical Antipsychotic Schizophrenia Patient Gray Matter Volume Work Memory Load 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Anterior cingulate gyrus


Blood oxygen level dependent


Common disease–common variant




Continuous performance test


Cerebrospinal fluid






Dopamine and cyclic AMP regulated phosphoprotein


Disrupted-in-schizophrenia 1


Dorsolateral prefrontal cortex


Deoxyribonucleic acid


Diffusion tensor imaging


Dysbindin 1


Extrapyramidal side effects


Frontal eye fields


Functional magnetic resonance imaging


Gray matter


Metabotropic glutamate receptor 3




Proton magnetic resonance spectroscopic imaging


Serotonin transporter promoter


Magnetic resonance imaging


Messenger ribonucleic acid




Neuroregulin 1


Positron emission tomography


Prefrontal cortex


Posterior-parietal cortex


Prepulse inhibition


Protein phosphatase 1, regulatory (inhibitor) subunit 1B


Supplementary motor area


Superior temporal gyrus


Voxel-based morphometry


Motion-sensitive visual Processing area


Ventrolateral prefrontal cortex


White matter



The authors thank Shabnam Hakimi for helpful comments on the manuscript.


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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Clinical Brain Disorders BranchGenes, Cognition, and Psychosis Program, National Institute of Mental Health, National Institutes of HealthBethesda, MD 20892USA

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