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Animal Models of Affective Behaviors and Drug Addiction

  • Eva Drews
  • Astrid Becker
  • Andras Bilkei-Gorzo
  • Andreas Zimmer
Chapter

Abstract

Psychiatric disorders have a strong heritability, and like most common disorders many gene variants, each with a small effect yize , contribute to the genetic risk. One of the challenges in complex genetics is to determine how different alleles interact with each other and with the environment in the context of disease etiology. Here we discuss mouse models that resemble aspects of syndromes of human psychiatric disorders, with particular emphasis on depression and drug addiction. These disorders rank among the top 10 causes of disability and morbidity worldwide and often occur together, thus resulting in a greater severity of health-related consequences. Mice have become the premier research organism, due to their excellent genetics. We have a large and ever-increasing number of mouse strains with defined genetic backgrounds, and the possibilities of precise genetic manipulations seem almost unlimited. Furthermore, environmental factors that are thought to influence disease outcome can be controlled, thus enabling researchers to study interactions between genes and the environment.

Keywords

Conditioned Place Preference Drug Addiction Progressive Ratio Tail Suspension Test Chronic Mild Stress 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CMS

Chronic mild stress

Cnr1

Cannabinoid receptor 1

CPP

Conditioned place preference

DMS

Diagnostic and Statistical Manual of Mental Disorders

DNA

Deoxyribonucleic acid

F1

First filial generation

FST

Forced swim test

kHz

Kilohertz

OB

Olfactory bulbectomy

PR

Progressive ratio

QTL

Quantitative trait loci

RI

Recombinant inbred

SSR

Simple sequence repeats

SSRIs

Selective serotonin reuptake inhibitors

STR

Short tandem repeats

TST

Tail suspension test

USV

Ultrasonic vocalisation

VNTR

Variable number tandem repeats

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Eva Drews
  • Astrid Becker
  • Andras Bilkei-Gorzo
  • Andreas Zimmer
    • 1
  1. 1.Institute of Molecular PsychiatryLife & Brain CenterBonnGermany

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