Skip to main content
SpringerLink
Log in

Translational Immunomics of Cancer Immunoprevention

  • Chapter
  • First Online:
Clinical Applications of Immunomics

Part of the book series: Immunomics Reviews ((IMMUN,volume 2))

  • 537 Accesses

Abstract

Cancer immunoprevention, a recent development of tumor immunology based on vaccines and other immunological maneuvers to actively reduce the risk of cancer development, will greatly benefit from immunomic approaches for its progress in basic research and for its translation to human applications. The main approaches discussed in this chapter are the use of genetically modified mouse models, microarray studies, and data mining approaches to define antitumor immune responses and to discover new oncoantigens, and agent-based mathematical models to simulate tumor–immune system interactions and to perfect vaccination protocols.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Amanna, I. J., Carlson, N. E., and Slifka, M. K. 2007. Duration of humoral immunity to common viral and vaccine antigens. N. Engl. J. Med. 357:1903–1915.

    Article  PubMed  CAS  Google Scholar 

  • Astolfi, A., Landuzzi, L., Nicoletti, G., De Giovanni, C., Croci, S., Palladini, A., Ferrini, S., Iezzi, M., Musiani, P., Cavallo, F., Forni, G., Nanni, P., and Lollini, P. L. 2005a. Gene expression analysis of immune-mediated arrest of tumorigenesis in a transgenic mouse model of HER-2/neu-positive basal-like mammary carcinoma. Am. J. Pathol. 166:1205–1216.

    Article  CAS  Google Scholar 

  • Astolfi, A., Rolla, S., Nanni, P., Quaglino, E., De Giovanni, C., Iezzi, M., Musiani, P., Forni, G., Lollini, P. L., Cavallo, F., and Calogero, R. A. 2005b. Immune prevention of mammary carcinogenesis in HER-2/neu transgenic mice: a microarray scenario. Cancer Immunol. Immunother. 54:599–610.

    Article  CAS  Google Scholar 

  • Bao, T., Prowell, T., and Stearns, V. 2006. Chemoprevention of breast cancer: tamoxifen, raloxifene, and beyond. Am. J. Ther. 13:337–348.

    Article  PubMed  Google Scholar 

  • Boggio, K., Nicoletti, G., Di Carlo, E., Cavallo, F., Landuzzi, L., Melani, C., Giovarelli, M., Rossi, I., Nanni, P., De Giovanni, C., Bouchard, P., Wolf, S., Modesti, A., Musiani, P., Lollini, P. L., Colombo, M. P., and Forni, G. 1998. Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice. J. Exp. Med. 188:589–596.

    Article  PubMed  CAS  Google Scholar 

  • Cavallo, F., Calogero, R. A., and Forni, G. 2007. Are oncoantigens suitable targets for anti-tumour therapy? Nat. Rev. Cancer 7:707–713.

    CAS  Google Scholar 

  • Chang, M. H., Chen, T. H., Hsu, H. M., Wu, T. C., Kong, M. S., Liang, D. C., Ni, Y. H., Chen, C. J., and Chen, D. S. 2005. Prevention of hepatocellular carcinoma by universal vaccination against hepatitis B virus: the effect and problems. Clin. Cancer Res. 11:7953–7957.

    Article  PubMed  CAS  Google Scholar 

  • Croci, S., Nicoletti, G., Landuzzi, L., De Giovanni, C., Astolfi, A., Marini, C., Di Carlo, E., Musiani, P., Forni, G., Nanni, P., and Lollini, P. L. 2004. Immunological prevention of a multigene cancer syndrome. Cancer Res. 64:8428–8434.

    Article  PubMed  CAS  Google Scholar 

  • Cuzick, J., Powles, T., Veronesi, U., Forbes, J., Edwards, R., Ashley, S., and Boyle, P. 2003. Overview of the main outcomes in breast-cancer prevention trials. Lancet 361:296–300.

    Article  PubMed  CAS  Google Scholar 

  • De Giovanni, C., Nicoletti, G., Landuzzi, L., Astolfi, A., Croci, S., Comes, A., Ferrini, S., Meazza, R., Iezzi, M., Di Carlo, E., Musiani, P., Cavallo, F., Nanni, P., and Lollini, P. L. 2004. Immunoprevention of HER-2/neu transgenic mammary carcinoma through an interleukin 12-engineered allogeneic cell vaccine. Cancer Res. 64:4001–4009.

    Article  PubMed  Google Scholar 

  • Di Carlo, E., Diodoro, M. G., Boggio, K., Modesti, A., Modesti, M., Nanni, P., Forni, G., and Musiani, P. 1999. Analysis of mammary carcinoma onset and progression in HER-2/neu oncogene transgenic mice reveals a lobular origin. Lab. Invest. 79:1261–1269.

    PubMed  Google Scholar 

  • Dorne, C., Dorigo, M., and Glover, F. 1999. New ideas in optimization. McGraw-Hill.

    Google Scholar 

  • Fabian, C. J., and Kimler, B. F. 2005. Selective estrogen-receptor modulators for primary prevention of breast cancer. J. Clin. Oncol. 23:1644–1655.

    Article  PubMed  CAS  Google Scholar 

  • Frese, K. K., and Tuveson, D. A. 2007. Maximizing mouse cancer models. Nat. Rev. Cancer 7:645–658.

    Article  PubMed  CAS  Google Scholar 

  • Garrido, F., and Algarra, I. 2001. MHC antigens and tumor escape from immune surveillance. Adv. Cancer Res. 83:117–158.

    Article  PubMed  CAS  Google Scholar 

  • Green, J. E., and Hudson, T. 2005. The promise of genetically engineered mice for cancer prevention studies. Nat. Rev. Cancer 5:184–198.

    Article  PubMed  CAS  Google Scholar 

  • Lollini, P. L., Cavallo, F., Nanni, P., and Forni, G. 2006. Vaccines for tumour prevention. Nat. Rev. Cancer 6:204–216.

    Article  PubMed  CAS  Google Scholar 

  • Lollini, P. L., De Giovanni, C., Pannellini, T., Cavallo, F., Forni, G., and Nanni, P. 2005a. Cancer immunoprevention. Future Oncol. 1:57–66.

    Article  CAS  Google Scholar 

  • Lollini, P. L., and Forni, G. 2003. Cancer immunoprevention: tracking down persistent tumor antigens. Trends Immunol. 24:62–66.

    Article  PubMed  CAS  Google Scholar 

  • Lollini, P. L., Motta, S., and Pappalardo, F. 2006. Discovery of cancer vaccination protocols with a genetic algorithm driving an agent based simulator. BMC Bioinformatics 7: 352.

    Article  PubMed  Google Scholar 

  • Lollini, P. L., Nicoletti, G., Landuzzi, L., De Giovanni, C., and Nanni, P. 2005b. New target antigens for cancer immunoprevention. Curr. Cancer Drug Targets 5:221–228.

    Article  CAS  Google Scholar 

  • Motta, S., Castiglione, F., Lollini, P., and Pappalardo, F. 2005. Modelling vaccination schedules for a cancer immunoprevention vaccine. Immunome Res. 1:5.

    Article  PubMed  Google Scholar 

  • Musiani, P., Modesti, A., Giovarelli, M., Cavallo, F., Colombo, M. P., Lollini, P. L., and Forni, G. 1997. Cytokines, tumour-cell death and immunogenicity: a question of choice. Immunol. Today 18:32–36.

    Article  PubMed  CAS  Google Scholar 

  • Nanni, P., Landuzzi, L., Nicoletti, G., De Giovanni, C., Rossi, I., Croci, S., Astolfi, A., Iezzi, M., Di Carlo, E., Musiani, P., Forni, G., and Lollini, P. L. 2004. Immunoprevention of mammary carcinoma in HER-2/neu transgenic mice is IFN-gamma and B cell dependent. J. Immunol. 173:2288–2296.

    PubMed  CAS  Google Scholar 

  • Nanni, P., Nicoletti, G., De Giovanni, C., Landuzzi, L., Di Carlo, E., Cavallo, F., Pupa, S. M., Rossi, I., Colombo, M. P., Ricci, C., Astolfi, A., Musiani, P., Forni, G., and Lollini, P. L. 2001. Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2/neu transgenic mice. J. Exp. Med. 194:1195–1205.

    Article  PubMed  CAS  Google Scholar 

  • Nanni, P., Nicoletti, G., Palladini, A., Croci, S., Murgo, A., Antognoli, A., Landuzzi, L., Fabbi, M., Ferrini, S., Musiani, P., Iezzi, M., De Giovanni, C., and Lollini, P. L. 2007. Antimetastatic activity of a preventive cancer vaccine. Cancer Res. 67:11037–11044.

    Article  PubMed  CAS  Google Scholar 

  • Nanni, P., Pupa, S. M., Nicoletti, G., De Giovanni, C., Landuzzi, L., Rossi, I., Astolfi, A., Ricci, C., De Vecchi, R., Invernizzi, A. M., Di Carlo, E., Musiani, P., Forni, G., Menard, S., and Lollini, P. L. 2000. p185(neu) protein is required for tumor and anchorage-independent growth, not for cell proliferation of transgenic mammary carcinoma. Int. J. Cancer 87:186–194.

    Article  PubMed  CAS  Google Scholar 

  • Nemhauser, G. L., and Wolsey, L. A. 1998. Integer and combinatiorial optimization. New York, NY: Wiley.

    Google Scholar 

  • Noguchi, Y., Jungbluth, A., Richards, E. C., and Old, L. J. 1996. Effect of interleukin 12 on tumor induction by 3-methylcholanthrene. Proc. Natl. Acad. Sci. U.S.A. 93:11798–11801.

    Article  PubMed  CAS  Google Scholar 

  • Pappalardo, F., Lollini, P. L., Castiglione, F., and Motta, S. 2005. Modeling and simulation of cancer immunoprevention vaccine. Bioinformatics. 21:2891–2897.

    Article  PubMed  CAS  Google Scholar 

  • Quaglino, E., Iezzi, M., Mastini, C., Amici, A., Pericle, F., Di Carlo, E., Pupa, S. M., De Giovanni, C., Spadaro, M., Curcio, C., Lollini, P., Musiani, P., Forni, G., and Cavallo, F. 2004. Electroporated DNA vaccine clears away multifocal mammary carcinomas in Her-2/neu transgenic mice. Cancer Res. 64 2858–2864.

    Article  PubMed  CAS  Google Scholar 

  • Sawaya, G. F., and Smith-McCune, K. 2007. HPV vaccination--more answers, more questions. N. Engl. J. Med. 356:1991–1993.

    Article  PubMed  CAS  Google Scholar 

  • Shankaran, V., Ikeda, H., Bruce, A. T., White, J. M., Swanson, P. E., Old, L. J., and Schreiber, R. D. 2001. IFN-gamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410:1107–1111.

    Article  PubMed  CAS  Google Scholar 

  • Smyth, M. J., Dunn, G. P., and Schreiber, R. D. 2006. Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity. Adv. Immunol. 90:1–50.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, B. W., and Coates, A. S. 2005. Cancer prevention: a global perspective. J. Clin. Oncol. 23:392–403.

    Article  PubMed  Google Scholar 

Download references

Grant support

EC contract FP6-2004-IST-4, No.028069 (ImmunoGrid); Italian Association for Cancer Research (Milan, Italy); Italian Ministry for Education, University and Research PRIN projects; Italian Ministry of Health; University of Bologna (Bologna, Italy); AlmaMedicina Foundation (Bologna, Italy); Italian Leukemia Association; ‘‘Pallotti’’ funds, Department of Experimental Pathology, University of Bologna.

A. Palladini is the recipient of a fellowship from the Italian Foundation for Cancer Research (Milan, Italy). S. Croci is the recipient of a research fellowship (‘‘Assegno di Ricerca’’) from the University of Bologna. A. Antognoli is the recipient of a Ph.D. fellowship from the University of Bologna.

Author information

Authors and Affiliations

  1. Section of Cancer Research, Department of Experimental Pathology, University of Bologna, Viale Filopanti 22, I-40126 Bologna, Italy

    Pier-Luigi Lollini

Authors
  1. Pier-Luigi Lollini
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pier-Luigi Lollini .

Editor information

Editors and Affiliations

    Rights and permissions

    Reprints and permissions

    Copyright information

    © 2009 Springer Science+Business Media, LLC

    About this chapter

    Cite this chapter

    Lollini, PL. (2009). Translational Immunomics of Cancer Immunoprevention. In: Falus, A. (eds) Clinical Applications of Immunomics. Immunomics Reviews, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79208-8_12

    Download citation

    Publish with us

    Policies and ethics

    Search

    Navigation