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Ficolins: Structure, Function and Associated Diseases

  • Xiao-Lian Zhang
  • Mohammed A.M. Ali
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 632)

Abstract

Innate immunity relies upon the ability of a few pattern recognition molecules to sense molecular markers. Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. Three ficolins have been identified in humans: L-ficolin, H-ficolin and M-ficolin (also referred to as ficolin-2, -3 and -1, respectively). They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Upon recognition of the infectious agent, the ficolins act through two distinct routes: initiate the lectin pathway of complement activation through attached serine proteases (MASPs), and a primitive opsonophagocytosis thus limiting the infection and concurrently orchestrating the subsequent adaptive clonal immune response. Recently a lot of reports showed that dysfunction or abnormal expressions of ficolins may play crucial roles in the pathogenesis of human diseases including: (1) infectious and inflammatory diseases, e.g., recurrent respiratory infections; (2) apoptosis, and autoimmune disease; (3) systemic lupus erythematosus; (4) IgA nephropathy; (5) clinical syndrome of preeclampsia; (6) other diseases associated factor e.g. C-reactive protein. Precise identification of ficolins functions will provide novel insight in the pathogenesis of these diseases and may provide novel innate immune therapeutic options to treat disease progression. This review discusses the structures, functions, and clinical implications of ficolins and summarizes the reports on the roles of ficolins in human diseases.

Keywords

Systemic Lupus Erythematosus Invasive Pneumococcal Disease Capsular Polysaccharide Lectin Pathway Recurrent Respiratory Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (30370310, 20532020, and 30670098), the 973 Program of China (2006CB504300), the Ministry of Education Scientific Research Foundation for the New Century Outstanding Scholars (NCET-04-0685), the Hubei Ministry of Public Health (JX1B074), and Hubei Province Science and Technology Department (2006ABD007, 2007ABC010, 2005AA304B04).

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.The State Key Laboratory of Virology, Department of Immunology, Hubei Province Key Laboratory of Allergy and Immune-related DiseasesWuhan University School of MedicineWuhanChina

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