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Platelet Mediated Complement Activation

  • Ellinor I.B. Peerschke
  • Wei Yin
  • Berhane Ghebrehiwet
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 632)

Abstract

The complement system comprises a series of proteases and inhibitors that are activated in cascade-like fashion during host defense (Makrides 1998). A growing body of evidence supports the hypothesis that immune mechanisms, including complement activation, are involved in inflammatory conditions associated with vascular injury (Acostan et al. 2004; Giannakopoulos et al. 2007), and disseminated intravascular coagulation associated with massive trauma (Huber-Lang, this volume). We propose that platelets and platelet derived microparticles focus complement to sites of vascular injury where regulated complement activation participates in clearing terminally activated platelets and microparticles from the circulation, and dysregulated complement activation contributes to inflammation and thrombosis. Given the central role of platelets in hemostasis and thrombosis, it is not surprising that activated complement components have been demonstrated in many types of atherosclerotic and thrombotic vascular lesions (Torzewsjki et al. 2007; Niculescu et al. 2004).

Keywords

Complement Activation Complement Component Classical Complement Pathway Terminal Complement Complex Induce Tissue Factor Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This work was supported in part by grants HL67211 (EIBP) and AI060866 (BG) from the National Institutes of Health, and an American Heart Association Heritage Affiliate postdoctoral award # 0625900T (WY).

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ellinor I.B. Peerschke
    • 1
  • Wei Yin
    • 2
  • Berhane Ghebrehiwet
    • 3
  1. 1.Department of PathologyThe Mount Sinai School of MedicineNew YorkUSA
  2. 2.Department of Mechanical and Aerospace EngineeringOklahoma State UniversityStillwaterUSA
  3. 3.Departments of Medicine and PathologyStony Brook UniversityStony BrookUSA

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