Food Intake Regulation by Central Complement System
Abstract. Complement C3a and C5a are released from C3 and C5, respectively, on activation of the complement system and play an important role in immune response. C3a, C5a and their receptors have been revealed to be present in the central nervous system (CNS) as well as the peripheral immune system. We found that centrally administered C3a suppresses food intake, while C5a stimulates food intake, and their food intake regulation may be associated with the prostaglandin system. We propose that complement C3a and C5a are regulators not only of the immune system but also of the CNS.
KeywordsDecrease Food Intake Food Intake Regulation Food Intake Suppression Stimulate Food Intake Suppress Food Intake
This work was supported in part by Grants-in-Aid for Scientific Research from the Japanese Society for the Promotion of Science to MY and KO, and a PROBRAIN grant from the Bio-oriented Technology Research Advancement Institution to MY.
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