Role of Complement in Ethanol-Induced Liver Injury

  • Michele T. Pritchard
  • Megan R. McMullen
  • M. Edward Medof
  • Abram Stavitsky
  • Laura E. Nagy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 632)


The complement cascade is a phylogenetically ancient part of our immune system and is critical to an organism’s ability to ward off infection. Interest in a possible role for the complement system in the development of ethanol-induced liver injury was inspired by the large body of data implicating the complement system in the development of acute and chronic inflammatory responses to bacteria/bacterial products, as well as in response to cell injury, both hallmarks of ethanol-induced liver injury. Recent investigations have demonstrated that complement is involved in the pathogenesis of ethanol-induced liver injury. Here we review the available data on the contribution of complement to ethanol-induced liver injury and then discuss the potential mechanisms by which the essential roles of complement in protecting the host from infection and facilitating wound healing may contribute to and/or protect from the pathogenesis of alcohol-induced liver injury.


Kupffer Cell Alcoholic Liver Disease Ethanol Exposure Complement Pathway Chronic Ethanol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by NIH grants AA013868 and AA11975 to LEN and AI23598 MEM.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Michele T. Pritchard
    • 1
  • Megan R. McMullen
  • M. Edward Medof
    • 4
  • Abram Stavitsky
    • 3
  • Laura E. Nagy
    • 2
  1. 1.Department of PathobiologyCleveland ClinicClevelandUSA
  2. 2.Department of GastroenterologyCleveland ClinicClevelandUSA
  3. 3.Department of Molecular Biology and MicrobiologyCase Western Reserve UniversityClevelandUSA
  4. 4.Department of PathologyCase Western Reserve UniversityClevelandUSA

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