Complement Factor H: Using Atomic Resolution Structure to Illuminate Disease Mechanisms

  • Paul N. Barlow
  • Gregory S. Hageman
  • Susan M. Lea
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 632)


Complement Factor H has recently come to the fore with variant forms implicated in a range of serious disease states. This review aims to bring together recent data concerning the structure and biological activity of this molecule to highlight the way in which a molecular understanding of function may open novel therapeutic possibilities. In particular we examine the evidence for and against the hypothesis that sequence variations in factor H may predispose to disease if they perturb its ability to recognise and respond appropriately to polyanionic carbohydrates on host surfaces that require protection from complement-mediated damage.


Hemolytic Uremic Syndrome Retinal Pigment Epithelium Dense Deposit Disease Polymorphic Residue Complement Regulatory Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Schools of Chemistry and Biological Sciences, Joseph Black Chemistry BuildingUniversity of EdinburghEdinburghUK
  2. 2.Department of Ophthalmology and Visual SciencesUniversity of IowaIowa CityUSA
  3. 3.Sir William Dunn School of PathologyUniversity of OxfordOxfordUK

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