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Intraperitoneal Chemotherapy

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Nolph and Gokal's Textbook of Peritoneal Dialysis

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For the nephrologist, the major therapeutic use of the peritoneal cavity is dialysis, but the peritoneum is a portal of entry for a wide variety of local and systemic therapies. Because of intravenous access problems in neonates, transfusion of packed red blood cells was one of the earliest uses of intraperitoneal (i.p.) therapy [1, 2]. Insulin is often placed in the dialysate in order to treat glucose intolerance during peritoneal dialysis [3], and i.p. insulin delivery is currently undergoing investigation as a means of long-term therapy in diabetes [4–6]. Erythropoietin, prescribed as replacement therapy for the anemia related to end-stage renal disease (ESRD), has been administered intraperitoneally [7, 8]. In contrast to these forms of i.p. therapy, which are designed to treat systemic illnesses, antibacterial agents are injected intraperitoneally in order to treat peritonitis [9]. In the past 20 years, i.p. chemotherapy has increasingly been evaluated for treatment of malignancies localized to the peritoneal cavity [10–29].

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  1. University of Mississippi Medical Center, Jackson, Mississippi

    Michael F. Flessner MD, PhD

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  1. School of Medicine Department of Medicine Division of Nephrology, MA436 Health Sciences Center, Columbia, MO 65212, USA

    Ramesh Khanna

  2. Academic Medical Center Dept. Medicine, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

    Raymond T. Krediet

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Flessner, M.F. (2009). Intraperitoneal Chemotherapy. In: Khanna, R., Krediet, R.T. (eds) Nolph and Gokal's Textbook of Peritoneal Dialysis. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78940-8_30

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