Long-Term Peritoneal Dialysis Patients

Changes in Membrane Structure and Function
  • O. Devuyst
  • R. van Westrhenen
  • N. Topley

Peritoneal dialysis (PD) has now been utilized for more than 25 years as a first-line therapy for the treatment of end-stage renal failure. It is now accepted that patient survival on PD is similar to hemodialysis when comparable analyses are made [1, 2]. As we have gathered new knowledge over the past decade, however, about the potential complications associated with long-term therapy, such as structural and functional alterations to the peritoneal membrane and end-stage sclerosing syndromes such as encapsulating peritoneal sclerosis (EPS), there remain legitimate concerns as to whether this mode of therapy can provide adequate treatment for end-stage renal disease in the longer term [3]. Despite advances in treatment guidelines there still remains in PD a considerable dropout rate in the early years of therapy, due mainly to infective episodes and membrane dysfunction [4].


Vascular Endothelial Growth Factor Peritoneal Dialysis Patient Dialysis Solution Peritoneal Membrane Encapsulate Peritoneal Sclerosis 
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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Division of NephrologyUniversité Catholiqué de Louvain Medical School Belgium
  2. 2.Dutch Medicines Evaluation Board, Clinical Assessor FT1Netherlands
  3. 3.School of Medicine Cardiff UniversityUnited Kingdom

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