Calcium, Phosphate, and Renal Osteodystrophy

  • A. Vardhan
  • A. J. Hutchison

The first association between uremia and bone disease was made by Lucas and reported in Lancet in 1883 [1]. However, it was not until nearly 40 years later that the major clinical and radiological manifestations of the skeletal changes were accurately defined [2, 3]. In 1943, the histopathology of osteitis fibrosa and osteomalacia was described [4], and in the same year the term “renal osteodystrophy” was coined by Liu and Chu [5]. Subsequently, the abnormalities of bone mass that occur in osteopenia and osteosclerosis were also described [6]. Following the research of Stanbury and Lumb [7, 8], there began a period of rapid advance in the understanding of the processes behind altered divalent ion metabolism, and the abnormalities of parathyroid hormone and vitamin D3 production that are seen in end-stage renal disease. Despite these advances with the introduction of vitamin D3 replacement therapy, new oral phosphate binders and, most recently, calcimimetic therapy, osteodystrophy remains a common complication of end-stage renal failure, and continues to pose diagnostic and therapeutic dilemmas for clinical nephrologists.


Peritoneal Dialysis Phosphate Binder Continuous Ambulatory Peritoneal Dialysis Peritoneal Dialysis Patient Renal Osteodystrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Institute of Nephrology & Transplantation, Manchester Royal Infirmary, Oxford RoadManchesterUK

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