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RegB/RegA, A Global Redox-Responding Two-Component System

  • Jiang Wu
  • Carl E. Bauer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 631)

Abstract

The RegB-RegA regulon from Rhodobacter capsulatus and Rhodobacter sphaeroides encodes proteins involved in numerous energy-generating and energy-utilizing processes such as photosynthesis, carbon fixation, nitrogen fixation, hydrogen utilization, aerobic and anaerobic respiration, denitrification, electron transport and aerotaxis. The redox signal that is detected by the membrane-bound sensor kinase, RegB, has been identified to be the ubiquinone pool in the membrane. Regulation of RegB autophosphorylation also involves a redox-active cysteine that is present in the cytosolic region of RegB. Both phosphorylated and unphosphorylated forms of the cognate response regulator RegA are capable of activating or repressing a variety of genes in the regulon. Highly conserved homologues of RegB and RegA have been found in a wide number of photosynthetic and nonphotosynthetic bacteria with evidence suggesting that RegB/RegA have a fundamental role in the transcription of redox-regulated genes in many bacterial species.

Keywords

Rhodobacter Sphaeroides Sensor Kinase Rhodobacter Capsulatus Histidine Protein Kinase Anoxygenic Photosynthetic Bacterium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  1. 1.Department of BiologyIndiana UniversityBloomingtonUSA

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