The BvgS/BvgA Phosphorelay System of Pathogenic Bordetellae

Structure, Function and Evolution
  • Dagmar Beier
  • Roy Gross
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 631)


In the genus Bordetella several important human and animal pathogens are classified with B. pertussis, the etiological agent of whooping cough, being medically the most relevant. In these bacteria expression of the most important virulence factors including several toxins, adhesins and colonization factors is controlled by a single master regulatory two-component system, the BvgS/BvgA system. This system represents a paradigm of a complex phosphorelay system that mediates a fine-tuned transcriptional response resulting in different expression levels of virulence factors during different stages of the infection process. In this chapter the current knowledge about signal perception and the molecular basis of differential gene expression controlled by a single two-component system is discussed.


Virulence Factor Pertussis Toxin Histidine Kinase Bordetella Pertussis Bordetella Bronchiseptica 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Landes Bioscience and Springer Science+Business Media 2008

Authors and Affiliations

  1. 1.Lehrstuhl für Mikrobiologie, BiozentrumUniversity of WürzburgWürzburgGermany

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