Child Clinical Neuropsychology of Drug Abuse

  • Arthur Macneill HortonJr
  • Arthur Macneill HortonIII

The use of substances to modify moods, behaviors and perceptions, drug abuse has been a problem since the beginning of recorded history.


Nucleus Accumbens Illicit Drug Ventral Tegmental Area Psychoactive Drug Neuropsychological Deficit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Acord, L. D., & Barker, D. D. (1973). Hallucinogenic drugs and cerebral deficit. Journal of Nervous and Mental Diseases, 156, 281-283.CrossRefGoogle Scholar
  2. Allen, D. N., & Landis, R. K. B. (1998). Neuropsychological correlates of substance abuse disorders. In P. J. Snyder & P. D. Nussbaum (Eds.), Clinical neuropsychology: A pocket handbook for assessment (pp. 591-612).Washington, DC: American Psychological Association.Google Scholar
  3. American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders. (4th ed.) Test Revision. Washington, DC: American Psychiatric Association.Google Scholar
  4. Benedict, R. H. B., & Horton, A. M. Jr. (1992). Neuropsychology of alcohol induced brain damage: Current perspectives on diagnosis, recovery, and prevention, In D. Templer, L. Hartlage, & W. G. Cannon (Eds.), Preventable brain damage: Brain vulnerability and brain health (pp. 146-160). New York: SpringerGoogle Scholar
  5. Bergman, H; Borg, S., & Holm, L. (1980). Neuropsychological impairments and the exclusive abuse of sedatives or hypnotics. American Journal of Psychiatry, 137, 215-217.PubMedGoogle Scholar
  6. Berry, G. Heaton, R. & Kirley, M. (1977) Neuropsychological deficits of chronic inhalant abusers. In B. Rumaek & A. Temple (Eds.), Management of the prisoned patient (pp. 59-83). Princeton: Sciences press.Google Scholar
  7. Bigler, E. D. (1979) Neuropsychological evaluation of adolescent patients hospitalized with chronic inhalant abuse. Clinical Neuropsychology, 1, 8-12.Google Scholar
  8. Bolla, K. I., McCann, D. U., & Ricaurte, G. A. (1998) Memory impairment in abstinent MDMA (“ecstasy”) users. Neurology, 51, 1532-1537.PubMedGoogle Scholar
  9. Bolla, K. I., Funderberk, F. R., & Cadet, J. L. (2000). Differential effects of cocaine and cocaine alcohol on neurocognitive performance. Neurology, 54, 2285-2299.PubMedGoogle Scholar
  10. Bolla, K. I., Eldreth, D. A., Matochik, & Cadet, J. L. (2005). Neural substrates of faulty decision-making in abstinent marijuana users. Neuroimage, 26, 480-492.CrossRefPubMedGoogle Scholar
  11. Carlin, A. S., & Trupin E. (1977). The effects of long-term chronic cannabis use on neuropsychological functioning. International Journal of Addiction, 12, 617-624.Google Scholar
  12. Carlin, A., Grant, I, Adams, K., & Reed, R. (1979). Is phencyclidine (PCP) abuse associated with organic mental impairment? American Journal of Drug and Alcohol Abuse, 6, 273-281.CrossRefPubMedGoogle Scholar
  13. Dafters, R. I., (2006). Chronic ecstasy (MDMA) use is associated with deficits in task-switching but not inhibition of memory updating executive functions. Drug and Alcohol Dependence, 83, 181-184.CrossRefPubMedGoogle Scholar
  14. Fastenau, P. S. (1998). Validity of regression-based norms: an empirical test of the comprehensive Norms with Older adults. Journal of Clinical and Experimental Neuropsychology, 20, 906-916.CrossRefPubMedGoogle Scholar
  15. Fastenau, P. S., & Adams, K. M. (1996). Heaton, Grant, and Matthews’s comprehensive norms: An overzealous attempt. Journal of Clinical and Experimental Neuropsychology, 18, 444-448.CrossRefGoogle Scholar
  16. Fields, F. S., & Fullerton, J. (1975). Influences of heroin addiction on neuropsychological functioning. Journal of Consulting and Clinical Psychology, 43, 114.CrossRefPubMedGoogle Scholar
  17. Fried, P. A., & Smith A. M. (2001). A literature review of the consequences of prenatal marijuana exposure: An emerging these of a deficiency in executive functioning. Neurotoxicology and Teratology, 23, 1-11.CrossRefPubMedGoogle Scholar
  18. Goldschmidt, L., Day, N. L., & Richardson, G. A. (2000). Effect of prenatal marijuana exposure on child behavior problems at age 10. Neurotoxicology and Teratology, 22, 325-336.CrossRefPubMedGoogle Scholar
  19. Grant, I, Rochford, J, Fleming, & Stunkard, A (1973). A Neuropsychological assessment of the effects of moderate marijuana use. Journal of Nervous and Mental Disease, 156, 278-280.CrossRefPubMedGoogle Scholar
  20. Grant, I, Mohns, L., Miller, M., & Reitan, R (1976). A neuropsychological study of polydrug users. Archives of General Psychiatry, 33, 973-978.PubMedGoogle Scholar
  21. Grant, I, Gonzales, Carey, C., Natarajan, L., & Wolfson, T. (2003). Non-acute (residual) Neurocognitive effects of cannabis use: a meta-analytic study. Journal of the International Neuropsychological Society, 9, 679-689.CrossRefPubMedGoogle Scholar
  22. Harwood, H. J., Fountain, D., Livermore, G. et al. (1998). Economic costs to society of alcohol and drug abuse and mental illness: 1992. Washington, DC: National Institute on Drug Abuse and National Institute on Alcohol and Alcohol Abuse.Google Scholar
  23. Heaton, R. K., Miller, S. W., Taylor, M. J., & Grant, I (2004). Revised comprehensive norms for an expanded Halstead-Reitan battery: Demographically adjusted neuropsychological norms for African American and Caucasian adults. Lutz, FL: Psychological assessment Resources.Google Scholar
  24. Horton, A. M., Jr. (1993). Future directions in the development of Addiction assessment instruments. In B. J. Rounsaville, F. M. Tims, A. M. Horton, Jr., & B. J. Sowder (Eds.), Diagnostic source book on drug abuse research and treatment (pp. 87-92) Rockville, Maryland: U.S. Department of Health and Human Services.Google Scholar
  25. Horton, A. M., Jr. (1996). Neuropsychology of drug abuse. In R. J. Sbordone & C. J. Long (Eds.), Ecological validity of neuropsychological testing (pp. 357-368). Delray Beach, Fla.: GR Press/St. Lucie Press.Google Scholar
  26. Horton, A. M. Jr. (1999). Prediction of brain damage severity: Demographic corrections. International Journal of Neuroscience. 97, 179-183.CrossRefPubMedGoogle Scholar
  27. Horton, A. M. Jr., & Fogelman, C. J. (1991). Clinical behavioral therapy with the addicted elderly client. In P. A. Wisocki (Ed.), Handbook of clinical behavioral therapy for the elderly client (pp. 299-315). New York: Plenum Press.Google Scholar
  28. Horton, A. M. Jr., & Wedding, D. (1984). Introduction to clinical and behavioral neuropsychology. New York: Praeger.Google Scholar
  29. Hubbard, R. L., Marsden, M. E., Rachal, J. V., Harwood, H. J., Cavanaugh, E. R., et al. (1989).Drug abuse treatment: A national study of effectiveness. Chapel Hill: University of North Carolina Press.Google Scholar
  30. Jovanovski, D., Erb, S., & Zakzanis, K. K. (2005). Neurocognitive deficits in cocaine users: a quantitative review of the evidence. Journal of Clinical and Experimental Neuropsychology, 27, 189-204.CrossRefPubMedGoogle Scholar
  31. Judd, L. L., & Grant, I. (1975). Brain dysfunction in chronic sedative users. Journal of Psychedelic Drugs, 7, 143-149.Google Scholar
  32. Kalechstein, A. D., Newton, T. F., & Green, M. (2003). Methamphetamine dependence is associated with neurocognitive impairment in the initial phases of abstinence. Journal of Neuropsychiatry and Clinical Neurosciences, 15, 215-220.PubMedGoogle Scholar
  33. Korman, M., Matthews, R. W., & Lovitt, R. (1981). Neuropsychological effects of abuse on inhalants. Perceptual & Motor Skills, 53, 547-553.Google Scholar
  34. McGlothlin, W. H., Arnold, D. D., & Freedman, D. X. (1969). Organicity measures following repeated LSD ingestion. Archives of General Psychiatry, 21, 704-709.PubMedGoogle Scholar
  35. Mendelson, J. H. & Meyer, R. E. (1972). Behavioral and biological concomitants of chronic marijuana smoking by heavy and casual users. In Marijuana: A signal of misunderstanding (Vol. 1). Washington, DC: U.S. Government Printing Office.Google Scholar
  36. Nordahl, T. E., Salo, R., & Leamon, M. (2003). Neuropsychological effects of chronic methamphetamine use on neurotransmitters and cognition: A review. Journal of Neuropsychiatry and Clinical Neurosciences, 15, 317-325.PubMedGoogle Scholar
  37. O'Malley, S. S., & Gawin, F. H. (1990). Abstinence symptomatology and neuropsychological deficits in chronic cocaine abusers. In J. W. Spencer & J. J. Boren (Eds.), Residual effects of abused drugs on behavior (pp. 179-190). National Institute on Drug Abuse Research Monograph 101, OHHS Pub. No (ADM) 90-1719. Washington, DC: Supt. of Docs., U.S. Gov't Printing Office.Google Scholar
  38. Page, J. B., Fletcher, J., & True, W. P. (1988). Psychosociocultural perspectives on chronic cannabis use: the Costa Rican followup. Journal of Psychoactive Drugs, 20, 57-65.PubMedGoogle Scholar
  39. Parrott, A. C. (2001). Human psychopharmacology of Ecstasy (MDMA): A review of 15 years f empirical research. Human Psychopharmacology, 16, 557-577.CrossRefPubMedGoogle Scholar
  40. Parson, O. A., & Farr, S. P. (1981). The neuropsychology of alcohol and drug use. In S. Filskov & T. J. Boll (Eds.), The handbook of clinical neuropsychology (pp. 320-365). New York: Wiley.Google Scholar
  41. Pope, H. G., & Yurgelun-Todd, D. (1996). The residual cognitive effects of heavy marijuana use in college students. Journal of the American Medical Association, 275, 521-527.CrossRefPubMedGoogle Scholar
  42. Reed, R., & Grant, I. (1990). The long term neurobehavioral consequence of substance abuse: conceptual and methodological challenge for future research. In J. W. Spencer & J. J. Boren (Eds.), Residual effects of abused drugs on behavior. Research Monograph 101 (pp 10-56). Rockville, MD: National Institute on Drug Abuse.Google Scholar
  43. Reitan, R. M. (1967). Psychological changes associated with aging and cerebral damage. Mayo Clinic Proceedings, 42, 653-673.PubMedGoogle Scholar
  44. Reitan, R. M., & Wolfson, D. (1993). The Halstead-Reitan Neuropsychological Battery (2 nd ed.,). Tucson, AZ: Neuropsychology Press.Google Scholar
  45. Reitan R. M., & Wolfson, D. (1995). Influence of age and education on neuropsychological test results. The Clinical Neuropsychologist, 9, 151-158.CrossRefGoogle Scholar
  46. Reitan, R. M., & Wolfson, D. (2005). The effect of age and education transformations on neuropsychological test scores of persons with diffuse or bilateral brain damage. Applied Neuropsychology, 12, 181-189.CrossRefPubMedGoogle Scholar
  47. Reneman, L., Booij, J., Majoie, C. B. L. M., van den Brink, W., & den Heeten, G. J. (2001). Investigating the potential neurotoxicity of Ecstasy (MDMD): An imaging approach. Human Psychopharmacology, 16, 579-588.CrossRefPubMedGoogle Scholar
  48. Rosenberg, N. L., Grigsby, J., Dreisbach, J., Busenbark, D., & Grigdby, P. (2002). Neuropsychological impairment and MRI abnormalities associated with chronic solvent abuse. Journal of Toxicology and Clinical Toxicology, 40(1), 21-34.CrossRefGoogle Scholar
  49. Rounsaville, B. J., Novelly, R. A., & Kleber, H. D. (1980). Neuropsychological impairments in opiate addicts: Risk factors. Annuals of the New York Academy of Science, 362, 79-80.CrossRefGoogle Scholar
  50. Rounsaville, B. J., Jones, C. Novelly, R. A., & Kleber, H. D. (1982). Neuropsychological functioning in opiate addicts. Journal of Nervous and Mental Diseases, 170, 209-216.CrossRefGoogle Scholar
  51. Tarter, R. E., & Edwards, K. L. (1987). Brief and comprehensive neuropsychological assessment of alcohol and substance abuse. In L. C. Hartlage, J. L. Hornsby, & M. J. Asken, (Eds.), Essentials of neuropsychological assessment (pp. 138-162), New York: Springer.Google Scholar
  52. Thompson, P. M., Hayashi, K. M., Simon, S. L., Geaga, J. A., Hong, M. S., Sui, Y., et al. (2004). Structural abnormalities in the brains of human subjects who have used methamphetamine. Journal of Neuroscience, 24, 6028-6036.CrossRefPubMedGoogle Scholar
  53. Tsushina, W., & Towne, W. (1977). Effects of paint sniffing on neuropsychological test performance. Journal of Abnormal Psychology, 86, 402-407.CrossRefGoogle Scholar
  54. Schwartz, R. H., Gruenewald, P. J., Klitzner, M., & Fedio, P. (1989). Short-term memory impairment in cannabis-dependent adolescents. American Journal of Diseases of Children, 143, 1214-1219.PubMedGoogle Scholar
  55. Simon, S. L., Domier, C. P., Sim, T., Richardson, K, Rawson, R. A., & Ling, W. (2002). Cognitive performance of current methamphetamine and cocaine abusers. Journal of Addictive Diseases, 21, 61-71.CrossRefPubMedGoogle Scholar
  56. Spencer, J. W., & Boren, J. J. (1990). Residual effects of abused drugs in behavior. Research Monograph 101, Rockville, MD: National Institute on Drug Abuse.Google Scholar
  57. Strickland, T. L., Mena, I., Villanueva-Meyer, J., Miller, B., Mehringer, C. M., Satz, P., & Myers, H. (1993) Cerebral perfusion and neuropsychological consequences of chronic cocaine use. Journal of Neuropsychiatry and Clinical Neurosciences, 5, 419-427.PubMedGoogle Scholar
  58. Substance Abuse and Mental Health Services Administration (2006). Results from the 2005 National Survey on Drug Use and Health (Office of Applied Studies, NHSDA Series H-30, DHHS Publication No. SMA 06-4194). Rockville, MD.Google Scholar
  59. Van Gorp, W. G., Wilkins, J. N., Hinkin, C. H., Moore, L. H., Horner, M. D., & Plotkin, D. (1999). Declarative and procedural memory functioning in abstinent cocaine abusers. Archives of General Psychiatry, 56, 85-89.CrossRefPubMedGoogle Scholar
  60. Volkow, N. D., Mullani, N., Gould, K. L., Adler, S., & Krajewski, K. (1988). Cerebral blood flow in chronic cocaine users: A study with positron omission tomography. British Journal of Psychiatry, 152, 641-648.CrossRefPubMedGoogle Scholar
  61. Volkow, N. D., Hitzmann, R., Wang, G. J., Fowler, J. S., Wolf, A. P., Dewey, S. L., et al. (1992). Long-term frontal metabolic changes in cocaine abusers. Synapse, 11, 184-190.CrossRefPubMedGoogle Scholar
  62. Wood, R. L., & Liossi, C. (2005). Long-term neuropsychological impact of brief exposure to organic solvents. Archives of Clinical Neuropsychology. 20(5), 655-665.CrossRefPubMedGoogle Scholar
  63. Woods, S. P., Rippeth, J. D., Conover, E., Gonzalez, R., Cherner, M., Heaton, R. K., (2005). Deficient strategic control of verbal encoding and retrieval in individuals with methamphetamine dependence. Neuropsychology, 19, 35-43.CrossRefPubMedGoogle Scholar
  64. Zakzanis, K. K., & Young, D. A. (2001). Memory impairment in abstinent MDMA (“ecstasy”) users: a longitudinal investigation. Neurology, 56(7), 966-969.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Arthur Macneill HortonJr
    • 1
  • Arthur Macneill HortonIII
    • 2
  1. 1.Psych AssociatesTowsonMaryland
  2. 2.Eastern Virginia Medical SchoolNorfolkVA

Personalised recommendations