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Nonstimulant Psychotropic Medication: Desired and Adverse Cognitive Events

  • Manuel L. Cepeda

This chapter reviews literature and presents guidelines for understanding the desired and adverse cognitive events associated with nonstimulant psychotropic medication.

Keywords

Antipsychotic Drug Atypical Antipsychotic Antipsychotic Medication Tardive Dyskinesia Psychotic Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Akdede, B. B. K., Alptekin, K., Kitis, A., Arkar, H. & Akvardar, Y. (2005). Effects of quetiapine on cognitive functions in schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 29, 233−238.CrossRefGoogle Scholar
  2. Aminoff, M. J., Marshall, J., Smith, E., & Wyke, M. (1974). Cognitive function in patients on lithium therapy. British Journal of Psychiatry, 125, 109−112.CrossRefPubMedGoogle Scholar
  3. Anderson, L. T., Campbell, M., Grega, D. M., Perry, R., Small, A. M., & Green, W. H. (1984). Haloperidol in the treatment of infantile autism: Effects upon learning and behavioral symptoms. American Journal of Psychiatry, 141, 1195−1202.PubMedGoogle Scholar
  4. Behrle, F. C., Elkin, M. T., & Laybourne, P. C. (1956). Evaluation of a conditioning device in the treatment of nocturnal enuresis. Pediatrics, 17, 849−856.PubMedGoogle Scholar
  5. Biederman, J., Baldessarini, R. J., Goldblatt, A., Lapey, K. A., Doyle, A., & Hesslein, P. (1993). A naturalistic study of 24-hour electrocardiographic recordings and echocardiographic findings in children and adolescents treated with desipramine. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 805−813.CrossRefPubMedGoogle Scholar
  6. Block, R. I., DeVoe, M., Stanley, B., Stanley, M., & Pomara, N. (1985). Memory performance in individuals with primary degenerative dementia: Its similarity to diazepam-induced impairments. Experimental Aging Research, 11, 151−155.PubMedGoogle Scholar
  7. Bonnel, H. L., Etevenon, P., Benyacoub, J., & Slowen, P. (1981). Intellectual efficiency in manic-depressive patients treated with lithium. Acta Psychiatrica Scandinavica, 64, 423−430.CrossRefPubMedGoogle Scholar
  8. Braff, D. L., & Saccuzzo, D. P. (1982). Effect of antipsychotic medication on speed of information processing in schizophrenic patients. American Journal of Psychiatry, 139, 1127−1130.PubMedGoogle Scholar
  9. Brumback, R. A., & Staton, R. D. (1980). Neuropsychological study of children during and after remission and endogenous depressive episodes. Perceptual and Motor Skills, 50, 1163−1167.PubMedGoogle Scholar
  10. Campbell, M., Small, A. M., Green, W. H., Jennings, M. A., Perry, R., Bennett, W. G., et al. (1982). Lithium and haloperidol in hospitalized aggressive children. Psychopharmacology Bulletin, 18, 126−130.Google Scholar
  11. Christodoulous, G. N., Kokkevi, A., Lykouras, E. P., Stefanis, C. N., & Papadimitriou, G. N. (1981). Effects of lithium on memory. American Journal of Psychiatry, 18, 847−848.Google Scholar
  12. Cleghorn, J. M., Kaplan, R. D., Szechtman, B., Szechtman, H., & Brown, G. M. (1990). Neuroleptic drug effects on cognitive function in schizophrenia. Schizophrenia Research, 3, 211−219.CrossRefPubMedGoogle Scholar
  13. Cole, S. O. (1986). Effects of benzodiazepines on acquisition and performance: A critical assessment. Neuroscience and Biobehavioral Reviews, 10, 265−272.CrossRefPubMedGoogle Scholar
  14. Cuesta, M. J., Peralta, V., Zarzuela, A. (2001). Effects of olanzapine and other antipsychotics on cognitive function in chronic schizophrenia: a longitudinal study.Schizophrenia Research, 48, 17−28.CrossRefPubMedGoogle Scholar
  15. deGier, J. J., 't Hart, B. J., Nelemans, F. A., & Bergman, H. (1981). Psychomotor performance and real driving performance of outpatients receiving diazepam. Psychopharmacology, 73, 340−344.CrossRefGoogle Scholar
  16. Department of Health and Human Services, United States Government (1982). Use of approved drugs for unlabeled indications. FDA Drug Bulletin, 12, 4−5.Google Scholar
  17. Dietch, J. T., & Jennings, R. K. (1988). Aggressive dyscontrol in patients treated with benzodiazepines. Journal of Clinical Psychiatry, 49, 184−188.PubMedGoogle Scholar
  18. DiMascio, A., Giller, D. R., & Shader, R. I. (1968). Behavioral toxicity of psychotropic drugs: III. Effects on perceptual and cognitive functions. Connecticut Medicine, 32, 771−775.PubMedGoogle Scholar
  19. DiMascio, A., Heninger, G., & Klerman, G. L. (1964). Psychopharmacology of imipramine and desipramine: A comparative study of their effects in normal males. Psychopharmacologia, 5, 361−371.CrossRefPubMedGoogle Scholar
  20. Dugas, J. E. (1977). Mood elevation and medication. Diseases of the Nervous System, 38, 958.PubMedGoogle Scholar
  21. Eitan, N., Levin, Y., Ben-Artzi, E., Levy, A., & Neumann, M. (1992). Effects of antipsychotic drugs on memory functions of schizophrenic patients. Acta Psychiatrica Scandinavica, 85, 74−76.CrossRefPubMedGoogle Scholar
  22. Fayen, M., Goldman, M. B., Moulthrop, M. A., & Luchins, D. J. (1988). Differential memory function with dopaminergic versus anticholinergic treatment of drug-induced extrapyramidal symptoms. American Journal of Psychiatry, 145, 483−486.PubMedGoogle Scholar
  23. Ferguson, H. B., & Simeon, J. G. (1984). Evaluating drug effects on children's cognitive functioning. Progress in Neuropsychopharmacology and Biological Psychiatry, 8, 683−686.CrossRefGoogle Scholar
  24. Gardos, G. (1980). Disinhibition of behavior by antianxiety drugs. Psychosomatics, 21, 1025-1026.Google Scholar
  25. Ghoneim, M. M., & Mewaldt, S. P. (1990). Benzodiazepines and human memory: A review. Anesthesiology, 72, 926−938.CrossRefPubMedGoogle Scholar
  26. Glass, R. M., Uhlenhuth, E. H., Hartel, F. W., Matuzas, W., & Fischman, M. W. (1981). Cognitive dysfunction and imipramine in outpatient depressives. Archives of General Psychiatry, 38, 1048−1051.PubMedGoogle Scholar
  27. Glass, R. M., Uhlenhuth, E. H., & Weinreb, H. (1978). Imipramine-reversible cognitive deficit in outpatient depressives. Psychopharmacology Bulletin, 14, 10−11.PubMedGoogle Scholar
  28. Golombok, S., Moodley, P., & Ladner, M. (1988). Cognitive impairment in long term benzodiazepine users. Psychological Medicine, 18, 365−374.CrossRefPubMedGoogle Scholar
  29. Good, K. P., Kiss, I., Buiteman, C., Woodley, H., Rui, Q., Whitehorn, D. & Kopala, L. (2002). Improvement in cognitive functioning in patients with first episode psychosis during treatment with quetiapine: an interim analysis. British Journal of Psychiatry, 181(Suppl. 43), s45-s49.CrossRefGoogle Scholar
  30. Gotestam, K. G., & Anderson, B. E. (1978). Subjective effects and vigilance after diazepam and oxazepam in normal subjects. Acta Psychiatrica Scandinavica, 274(Suppl.), 117-128.CrossRefGoogle Scholar
  31. Green, M. F., Marshall, B. D., Wirshing, W. C., Ames, D., Marden, S. R., McGurk, S., Kern, R. S., & Mintz, J. (1997). Does risperidone improve verbal working memory in treatment-resistant schizophrenia. The American Journal of Psychiatry, 154, 799-804.PubMedGoogle Scholar
  32. Guatrieri, C. T., & Patterson, D. R. (1986). Neuroleptic-induced tics in two hyperactive children. American Journal of Psychiatry, 143, 1176-1177.Google Scholar
  33. Hawkins, K. A., Mohamed, S., & Woods, S. W. (1999). Will the novel antipsychotics significantly ameliorate neuropsychological deficits and improve adaptive functioning in schizophrenia. Psychological Medicine, 29, 1-8.CrossRefPubMedGoogle Scholar
  34. Harvey, P. D. (2003). Ziprasidone and cognition: the evolving story. Journal of Clinical Psychiatry, 64(Suppl. 19), 33-39.PubMedGoogle Scholar
  35. Healey, M., Pickens, R., Meisch, R., & McKenna, T. (1983). Effects of clorazepate, diazepam, lorazepam and placebo on human memory. Journal of Clinical Psychiatry, 44, 436-439.PubMedGoogle Scholar
  36. Helper, M. M., Wilcott, R. C., & Garfield, S. L. (1963). Effects of chlorpromazine on learning and related processes in emotionally disturbed children. Journal of Consulting Psychology, 27, 1-9.CrossRefGoogle Scholar
  37. Henry, G. M., Weingartner, H., & Murphy, D. L. (1973). Influence of affective states and psychoactive drugs on verbal learning and memory. American Journal of Psychiatry, 130, 966-971.PubMedGoogle Scholar
  38. Hobi, V., Gastpar, M., Gastpar, G., Gilsdorf, U., Kielholz, P., & Schwarz, E. (1982). Driving ability of depressive patients under antidepressants. Journal of International Medical Research, 10, 65-81.PubMedGoogle Scholar
  39. Huey, L. Y., Janowsky, D. S., Judd, L. L., Abrams, A., Parker, D., & Clopton, P. (1981). Effects of lithium carbonate on methylphenidate-induced mood, behavior and cognitive process. Psychopharmacology, 73, 161-164.CrossRefPubMedGoogle Scholar
  40. Israel, M., & Beaudry, P. (1988). Carbamazepine in psychiatry: A review. Canadian Journal of Psychiatry, 33, 577-584.Google Scholar
  41. Jani, N. N., & Wise, T. N. (1988). Antidepressants and inhibited female orgasm: A literature review. Journal of Sex and Marital Therapy, 14, 279-284.PubMedGoogle Scholar
  42. Judd, L. L., Hubbard, B., Janowsky, D. S., Huey, L. Y., & Takahashi, K. I. (1977). The effect of lithium carbonate on the cognitive functions of normal subjects. Archives of General Psychiatry, 34, 355-357.PubMedGoogle Scholar
  43. Kardash, S., Hillman, E. S., & Werry, J. (1968). Efficacy of imipramine in childhood enuresis: A double-blind control study with placebo. Journal of the Canadian Medical Association, 99, 263-266.Google Scholar
  44. Keeler, M. H., Prange, A. J., & Reifler, C. B. (1966). Effects of imipramine and thioridazine on set and action. Diseases of the Nervous System, 27, 798-802.PubMedGoogle Scholar
  45. King, D. J. (1990). The effect of neuroleptics on cognitive and psychomotor function. British Journal of Psychiatry, 157, 799-811.CrossRefPubMedGoogle Scholar
  46. Koelega, H. S. (1989). Benzodiazepine and vigilance performance: A review. Psychopharmacology, 98, 145-156.CrossRefPubMedGoogle Scholar
  47. Kornetsky, C., Williams, J. E. G., & Bird, M. (1990). Attentional and motivational effects of psychoactive drugs. NIDA Research Monograph, 97, 177-192.PubMedGoogle Scholar
  48. Kowatch, R. A., Fristad, M., Birmaher, B., Wagner, K. D., Findling, R. L. & Hellander, M. (2005). Treatment guidelines for children and adolescents with bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 44, 213-235.CrossRefPubMedGoogle Scholar
  49. Kupietz, S. S., & Balka, E. B. (1976). Alterations in the vigilance performance of children receiving amitriptyline and methylphenidate pharmacotherapy. Psychopharmacology, 50, 29-33.CrossRefPubMedGoogle Scholar
  50. Kusumo, K. S., & Vaughn, M. (1977). Effects of lithium salts on memory. British Journal of Psychiatry, 131, 453-457.CrossRefPubMedGoogle Scholar
  51. Lamping, D. L., Spring, B., & Gelenberg, A. J. (1984). Effects of two antidepressants on memory performance in depressed outpatients: A double blind study. Psychopharmacology, 84, 254-261.CrossRefPubMedGoogle Scholar
  52. Legg, J. F., & Stiff, M. P. (1976). Drug-related test patterns of depressed patients. Psychopharmacology, 50, 205-210.CrossRefPubMedGoogle Scholar
  53. Lister, R. G. (1985). The amnestic actions of benzodiazepines in man. Neuroscience & Biobehavioral Reviews, 9, 87-94.CrossRefGoogle Scholar
  54. Livingston, R. L., Zucker, D. K., Isenberg, K., & Wetzel, R. D. (1983). Tricyclic antidepressants and delirium. Journal of Clinical Psychiatry, 44, 173-176.PubMedGoogle Scholar
  55. Lucki, I., Rickels, K., Giesecke, M. A., & Geller, A. (1987). Differential effects of the anxiolytic drugs, diazepam and buspirone, on memory function. British Journal of Clinical Pharmacology, 23, 207-211.PubMedGoogle Scholar
  56. Marusarz, T. Z., Wolpert, E. A., & Koh, S. D. (1981). Memory processing with lithium carbonate. Journal of Clinical Psychiatry, 42, 190-192.PubMedGoogle Scholar
  57. McClellan, J. (2005). Commentary: Treatment guidelines for child and adolescent bipolar disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 236-239.CrossRefPubMedGoogle Scholar
  58. Meador-Woodruff, J. H., Akil, M., Wisner-Carlson, R., & Grunhaus, L. (1988). Behavioral, and cognitive toxicity related to elevated plasma tricyclic antidepressant levels. Journal of Clinical Psychopharmacology, 8, 28-32.CrossRefPubMedGoogle Scholar
  59. Miller, N. S., & Gold, M. S. (1990). Benzodiazepine tolerance, dependence, abuse and addiction. Journal of Psychoactive Drugs, 22, 23-33.PubMedGoogle Scholar
  60. Murphy, D. L. (1977). The behavioral toxicity of monoamine oxidase-inhibiting antidepressants. Advances in Pharmacology and Chemotherapy, 14, 71-105.CrossRefPubMedGoogle Scholar
  61. Petrie, W. M. (1980). Sexual effects of antidepressants and psychomotor stimulant drugs. Modern Problems of Pharmacopsychiatry, 15, 77-90.PubMedGoogle Scholar
  62. Peuskens, J., Demily, C., & Thibaut, F. (2005). Treatment of cognitive dysfunction in schzophrenia. Clinical therapeutics: The International Peer-reviewed Journal of Drug Therapy, 27(Suppl 1). Retrieved August 3, 2006 from http://www/sciencedirect.com/journal/01492918
  63. Pishkin, V., Fishkin, S. M., Shurley, J. T., Lawrence, B. E., & Lovallo, W. R. (1978). Cognitive and psychophysiologic response to doxepin and chlordiazepoxide. Comprehensive Psychiatry, 19, 171-178.CrossRefPubMedGoogle Scholar
  64. Quinn, P. O., & Rapoport, J. L. (1975). One year follow-up of hyperactive boys treated with imipramine or methylphenidate. American Journal of Psychiatry, 132, 241-245.PubMedGoogle Scholar
  65. Rapoport, J. (1965). Childhood behavior and learning problems treated with imipramine. International Journal of Psychiatry, 1, 635-642.Google Scholar
  66. Rapoport, J. L., Quinn, P. O., Bradbard, G., Riddle, K. D., & Brooks, E. (1974). Imipramine and methylphenidate treatments of hyperactive boys. Archives of General Psychiatry, 30, 789-793.PubMedGoogle Scholar
  67. Riddle, M. A., Nelson, J. C., Kleinman, C. S., Rasmusson, A., Leckman, J. F., King, R. A., & Cohen, D. J. (1991). Sudden death in children receiving norpramin: A review of three reported cases and commentary. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 845-846.CrossRefGoogle Scholar
  68. Rivas-Vazquez, R. A., Blais, M. A., Rey, G. J. & Rivaz-Vazquez, A. A. (2000). Atypical antipsychotic medications: pharmacological profiles and psychological implications. Professional Psychology: Research and Practice, 31, 628-640.CrossRefGoogle Scholar
  69. Rosenbaum, J. F., & Pollack, M. H. (1988). Anhedonic ejaculation with desipramine. International Journal of Psychiatry in Medicine, 18, 85-88.CrossRefPubMedGoogle Scholar
  70. Ross, R. J., Smallberg, S., & Weingartner, H. (1984). The effects of desmethylimipramine on cognitive function in healthy subjects. Psychiatry Research, 12, 89-97.CrossRefPubMedGoogle Scholar
  71. Rossi, A., Daneluzzo, E., Tomassini, A., Struglia, F., Cavallaro, R., Smeraldi, E. & Stratta, P. (2006). The effect of verbalization strategy on Wisconsin card sorting test performance in schizophrenic patients receiving classical or atypical antipsychotics. BMC Psychiatry, 6. Retrieved August 3, 2006, from http://www.biomedcentral.com/1471-244x/6/3
  72. Segraves, R. T. (1988). Psychiatric drugs and inhibited female orgasm. Journal of Sex and Marital Therapy, 14, 202-207.PubMedGoogle Scholar
  73. Sharma, T. (1999). Cognitive effects of conventional and atypical antipsychotics in schizophrenia. The British Journal of Psychiatry, 174(Suppl. 38), 44-51.Google Scholar
  74. Shay, J., Sanchez, L. E., Cueva, J. E., Armenteros, J. L., Overall, J. E., & Campbell, M. (1993). Neuroleptic-related dyskinesias and stereotypes in autistic children: Videotaped ratings. Psychopharmacology Bulletin, 29, 359-363.PubMedGoogle Scholar
  75. Shen, W. W., & Lindbergh, S. S. (1990). Inhibited female orgasm resulting from psychotropic drugs: A five year updated clinical review. Journal of Reproductive Medicine, 37, 11-14.Google Scholar
  76. Silva, R. R., Malone, R. P., Anderson, L. T., Shay, J., & Campbell, M. (1993). Haloperidol withdrawal and weight changes in autistic children. Psychopharmacology Bulletin, 29, 287-291.PubMedGoogle Scholar
  77. Sliwa, J. A., & Lis, S. (1993). Drug-induced dysphagia. Archives of Physical Medicine and Rehabilitation, 74, 445-447.PubMedGoogle Scholar
  78. Spiegel, D. E., & Keith-Spiegel, P. (1967). The effects of carphenazine, trifluoperazine and chlorpromazine on ward behavior, physiological functioning and psychological test scores in chronic schizophrenic patients. The Journal of Nervous and Mental Disease, 144, 111-116.CrossRefPubMedGoogle Scholar
  79. Sprague, R. L., Barnes, K. R., & Werry, J. S. (1970). Methylphenidate and thioridazine: Learning, reaction time, activity and classroom behavior in disturbed children. American Journal of Orthopsychiatry, 40, 615-628.CrossRefPubMedGoogle Scholar
  80. Squire, L. R., Judd, L. L., Janowsky, D. S., & Huey, L. Y. (1980). Effects of lithium carbonate on memory and other cognitive functions. American Journal of Psychiatry, 137, 1042-1046.PubMedGoogle Scholar
  81. Staton, R. D., Wilson, H., & Brumback, R. A. (1981). Cognitive improvement associated with tricyclic antidepressant treatment of childhood major depressive illness. Perceptual and Motor Skills, 53, 219-234.PubMedGoogle Scholar
  82. Stenberg, A., & Lackgren, G. (1994). Desmopressin tablets in the treatment of severe nocturnal enuresis in adolescents. Pediatrics, 94, 841-846.PubMedGoogle Scholar
  83. Sternberg, D. E., & Jarvik, M. E. (1976). Memory functions in depression. Archives of General Psychiatry, 33, 219-224.PubMedGoogle Scholar
  84. Stip, E., Chouinard, S., & Boulay, L. J. (2005). On the trial of a cognitive enhancer for the treatment of schizophrenia. Progress in Neuro-psychopharmacology & Biological Psychiatry, 29, 219-232.CrossRefGoogle Scholar
  85. Strauss, W. H., & Kleiser, E. (1990). Cognitive disturbances in neuroleptic therapy. Acta Psychiatrica Scandinavica, 82 (Suppl. 358), 56-57.CrossRefGoogle Scholar
  86. Strauss, W. H., Kleiser, E., & Leuthcke, H. (1988). Dyscognitive syndromes in neuroleptic therapy. Pharmacopsychiatry, 21, 298-299.CrossRefPubMedGoogle Scholar
  87. Sweeney, J. A., Keilp, J. G., Haas, G. L., Hill, J., & Weiden, P. J. (1991). Relationships between medication treatments and neuropsychological test performance in schizophrenia. Psychiatry Research, 37, 297-308.CrossRefPubMedGoogle Scholar
  88. Thienhaus, O. J., Allen, A., Bennett, J. A., Chopra, Y. M., & Zemlan, F. P. (1990). Anticholinergic serum levels and cognitive performance. European Archives of Psychiatry and Clinical Neuroscience, 240, 28-33.CrossRefPubMedGoogle Scholar
  89. Thompson, P. J. (1991). Antidepressants and memory: A review. Human Psychopharmacology, 6, 79-90.CrossRefGoogle Scholar
  90. Thompson, P. J., & Trimble, M. R. (1982). Non-MAOI antidepressant drugs and cognitive functions: A review. Psychological Medicine, 12, 539-548.CrossRefPubMedGoogle Scholar
  91. Tingelstad, J. B. (1991). The cardiotoxicity of the tricyclics. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 845-846.PubMedGoogle Scholar
  92. Weickert, T. W., Goldberg, T. E., Marenco, S., Bigelow, L. B., Egan, M. F. & Weinberger, D. R. (2003). Comparison of cognitive performance during a placebo period and an atypical antipsychotic treatment period in schizophrenia: critical examination of confounds. Neuropsychopharmacology, 28, 1491-1500.CrossRefPubMedGoogle Scholar
  93. Weise, C. C., O'Reilly, P. P., & Hesbacher, P. (1972). Perphenazine-amitriptyline in neurotic underachieving students: A controlled study. Diseases of the Nervous System, 33, 318-325.PubMedGoogle Scholar
  94. Weiss, A. A., Robinson, S., & Dasberg, H. (1973). Changes in mental functioning accompanying antipsychotic drug therapy. Annals of Psychiatry and Related Disciplines, 11, 134-140.PubMedGoogle Scholar
  95. Werry, J. S., Aman, M. G., & Diamond, E. (1979). Imipramine and methylphenidate in hyperactive children. Journal of Child Psychology and Psychiatry, 21, 27-35.CrossRefGoogle Scholar
  96. Werry, J. S., Dowrick, P. W., Lampen, E. L., & Vamos, M. J. (1975). Imipramine in enuresis—Psychological and physiological effect. Journal of Child Psychology and Psychiatry, 16, 289-299.CrossRefPubMedGoogle Scholar
  97. Werry, J. S., Weiss, G., Douglas, V., & Martin, M. A. (1966). Studies on the hyperactive child: The effect of chlorpromazine upon behavior and learning ability. Journal of the American Academy of Child Psychiatry, 5, 292-312.CrossRefPubMedGoogle Scholar
  98. Wittenborn, J. R. (1988). Assessment of the effect of drugs on memory. Psychopharmacology Series, 6, 67-78.PubMedGoogle Scholar
  99. Woodward, N. D., Purdon, S. E., Meltzer, H. Y. & Zald, D. H. (2005). A meta-analysis of neuropsychological change to clozapine, olanzepine, quetiapine, and risperidone in schizophrenia. International Journal of Neuropsychopharmacology, 8, 457-472.CrossRefPubMedGoogle Scholar
  100. Wright, P. & O’Flaherty, L. (2003). Antipsychotic drugs: atypical advantages and typical disadvantages. Irish Journal of Psychological Medicine, 20, 24-27.Google Scholar
  101. Zimmermann-Tansella, C. (1984). Psychological performance of normal subjects on tasks commonly used in evaluation of anxiolytic drugs. Perceptual and Motor Skills, 58, 803-810.PubMedGoogle Scholar
  102. Zisook, S., & DeVaul, R. (1977). Adverse behavioral effects of benzodiazepines. The Journal of Family Practice, 5, 963-966.PubMedGoogle Scholar

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Authors and Affiliations

  • Manuel L. Cepeda
    • 1
  1. 1.Department of Psychiatry, College of MedicineUniversity of South AlabamaMobile

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